Abstract: Described are controlled-release solid dosage forms of mesalamine. In one aspect of the invention the controlled-release solid dosage forms of mesalamine are capsules comprising a plurality of coated mini-tablets. Another aspect of the invention relates to a method of treating a patient suffering from inflammatory bowel disease, comprising the step of administering to the patient a therapeutically effective amount of the solid dosage form. The invention also relates to methods of inducing remission of inflammatory bowel disease and maintaining remission of inflammatory bowel disease. In certain aspects, the inflammatory bowel disease is ulcerative colitis or Crohn's disease.

Abstract: A field image is formed using a tristimulus color model and used to detect target plants or entities on a field. Through the use of a luminance parameter floor, hue and saturation selection steps, feature recognition, a sizing floor and an aspect ratio ceiling, a very fast way is devised to recognize a target plant without need for consulting plant attribute databases, or to analyze spectral or other specialized data for comparison with known attributes. This allows a low calculational processing load and use of simple hardware such as a single board computer to handle machine vision in real time. Treatment steps can include a spray event, a light treatment, and a thermal/mechanical trauma.

Abstract: The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The electronics portion includes a processor and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls the operation of the device and is data communication with the actuator, motor, sensor and interface. The invention provides for autonomous operation, that is, without intervention of the user.

Abstract: The present invention relates to a valve system for an inflatable portion of an indwelling medical device and more particularly to a valve system for fluid regulation of a catheter comprising a fluid inflatable portion that undergoes pressure changes within the body during use.

Abstract: The present invention relates to a valve system for an inflatable portion of an indwelling medical device and more particularly to a valve system for fluid regulation of a catheter comprising a fluid inflatable portion that undergoes pressure changes within the body during use.

Abstract: The invention relates to analyte monitoring/drug delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The invention can optionally provide for calibration without intervention of the user and can also provide for semi-continuous monitoring for day and night time. The invention can provide up to four, or more, weeks of operation. The invention can provide for a device that is relatively small in size, and therefore unobtrusive. The invention can also provide for device with remote control and interactive electronics. The invention may be also used for the delivery of various pharmaceutical agents.

Abstract: The present invention relates to a valve system for an inflatable portion of an indwelling medical device and more particularly to a valve system for fluid regulation of a catheter comprising a fluid inflatable portion that undergoes pressure changes within the body during use.

Abstract: Described are controlled-release solid dosage forms of mesalamine. In one aspect of the invention the controlled-release solid dosage forms of mesalamine are capsules comprising a plurality of coated mini-tablets. Another aspect of the invention relates to a method of treating a patient suffering from inflammatory bowel disease, comprising the step of administering to the patient a therapeutically effective amount of the solid dosage form. The invention also relates to methods of inducing remission of inflammatory bowel disease and maintaining remission of inflammatory bowel disease. In certain aspects, the inflammatory bowel disease is ulcerative colitis or Crohn's disease.

Abstract: A method and system is disclosed for receiving patient test data from a point of care computer, identifying additional required data missing from the patient test data according to electronic health record provider requirements, transmitting an indication to the point of care computer of the additional required data to be input by an operator of the point of care computer; receiving operator input data from the operator; and adding the input data to the patient test data to store complete patient test data.

Abstract: A licensed electronic investment portfolio management bidding system running on a computing device comprises of a website interface allowing an owner of investment portfolios to list their investment portfolio in a directory or post the investment portfolio in an investment marketplace. Approved financial advisors may submit requests to manage an investment portfolio listed or bid on a listed investment portfolio. The portfolio owner awards management to a financial advisor and transfers ownership of the portfolio to a controlling company which grants access to the awarded financial advisor. The present invention allows an investment portfolio owner to place their investment portfolio up to be competed for by financial advisors.

Abstract: An apparatus and method for operating a packer and a fracture valve. The packer may include a tubular mandrel having a longitudinal bore with an annular packing element and a first piston disposed around the mandrel, wherein the first piston is operable to set the packing element, and a second piston operable to isolate fluid communication between the first piston and the mandrel bore. The fracture valve may include a tubular mandrel having a longitudinal bore and a port, a piston operable to close fluid communication between the bore and the port, and a latch disposed between the piston and the mandrel operable to resist movement of the piston.

Abstract: A method of classifying items from reflected signals returned from said items is disclosed, the method comprising: processing said return signals to discriminate between a first set of signals indicative of items of interest and a further set of signals indicative of clutter; identifying items from said first set of signals and classifying them as a first class of item; processing said further set of signals to identify a second set of signals indicative of further items of interest; identifying items from said second set of signals and classifying them as a second class of item.

Abstract: The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The electronics portion includes a processor and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls the operation of the device and is data communication with the actuator, motor, sensor and interface. The invention provides for autonomous operation, that is, without intervention of the user.

Abstract: This invention relates to aryl urea compounds in combination with cytotoxic or cytostatic agents for use in treating raf kinase mediated diseases such as cancer.

Abstract: A licensed electronic investment portfolio management bidding system comprises of a website interface allowing an owner of investment portfolios to list their investment portfolio in a directory or post the investment portfolio in an investment marketplace. Approved financial advisors may submit requests to manage an investment portfolio listed or bid on a listed investment portfolio. The portfolio owner awards management to a financial advisor and transfers ownership of the portfolio to a controlling company which grants access to the awarded financial advisor. The present invention allows an investment portfolio owner to place their investment portfolio up to be competed for by financial advisors.

Abstract: Pyrazole urea compounds, pharmaceutical compositions which contain them and methods for treating cancer using them.

Abstract: An apparatus and method for operating a packer and a fracture valve is shown. The packer may include a tubular mandrel having a longitudinal bore with an annular packing element and a first piston disposed around the mandrel, wherein the first piston is operable to set the packing element, and a second piston operable to isolate fluid communication between the first piston and the mandrel bore. The fracture valve may include a tubular mandrel having a longitudinal bore and a port, a piston operable to close fluid communication between the bore and the port, and a latch disposed between the piston and the mandrel operable to resist movement of the piston.

Abstract: A method of classifying items from reflected signals returned from said items is disclosed, the method comprising: processing said return signals to discriminate between a first set of signals indicative of items of interest and a further set of signals indicative of clutter; identifying items from said first set of signals and classifying them as a first class of item; processing said further set of signals to identify a second set of signals indicative of further items of interest; identifying items from said second set of signals and classifying them as a second class of item.

Abstract: An apparatus and method for operating a packer and a fracture valve is shown. The packer may include a tubular mandrel having a longitudinal bore with an annular packing element and a first piston disposed around the mandrel, wherein the first piston is operable to set the packing element, and a second piston operable to isolate fluid communication between the first piston and the mandrel bore. The fracture valve may include a tubular mandrel having a longitudinal bore and a port, a piston operable to close fluid communication between the bore and the port, and a latch disposed between the piston and the mandrel operable to resist movement of the piston.