Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: A gaze detection assembly comprises a plurality of infrared (IR) light emitters configured to emit IR light toward a user eye and an IR camera configured to sequentially capture IR images of the user eye. A controller is configured to, during a reference frame, control the plurality of IR light emitters to emit IR light toward the user eye with a reference intensity distribution. During the reference frame, an IR image is captured depicting a first glint distribution on the user eye. Based at least in part on the first glint distribution, during a subsequent frame, the plurality of IR light emitters are controlled to emit IR light toward the user eye with a subsequent intensity distribution, different than the reference intensity distribution. During the subsequent frame, a second IR image is captured depicting a second glint distribution on the user eye.

Abstract: An example system for bacteria, algae and/or bacteria detection is provided. The system includes a database configured to electronically store data. The data includes a detection model trained based on historical bacteria, algae and/or cyanobacteria identification and cell count data. The system includes a processing device in communication with the database. The processing device is configured to receive as input an electronic image of a water sample, electronically detect bacteria, algae and/or cyanobacteria in the electronic image, execute the detection model to identify an organism responsible for the detected bacteria, algae and/or cyanobacteria, and estimate a cell count of the responsible organism based on the electronic image.

Abstract: A connector assembly that includes a connector that has a ferrule and a latch. The latch is movable about a connection point. The connector assembly also includes a boot that is removably mounted to the connector. The boot is axially slidable to move the latch. The connector assembly also includes a locking assembly to selectively lock the boot from sliding axially relative to the connector.

Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Abstract: An adapter block assembly includes an adapter block, a circuit board arrangement, and a cover attached to the adapter block so that the circuit board arrangement is held to the adapter block by the cover. Contact assemblies can be disposed between the adapter block and the circuit board arrangement. The cover can be latched, heat staked, or otherwise secured to the adapter block. Each component of the adapter block assembly can include one or more parts (e.g., multiple adapter blocks, multiple circuit boards, and/or multiple cover pieces).

Abstract: A method for inferring a status asset information from data of a first type gathered by a first asset tracking device is provided. The method includes determining that a first asset tracking device coupled to a first asset and a second asset tracking device coupled to a second asset are travelling together, that the first asset tracking device has a first operating mode, and that the second asset tracking device has a second operating mode, which is different from the first operating mode of the first asset tracking device. In response, the second asset tracking device enters into a low-power mode in which it either does not gather data of the first type or does so at a reduced rate. Status information related to the second asset may be inferred from data of the first type gathered by the first asset tracking device.

Abstract: Yarns and fabrics that include modacrylic fibers are described herein. A yarn and/or fabric may include modacrylic fibers, meta-aramid fibers, anti-static fibers, and optionally para-aramid fibers. In some embodiments, the modacrylic fibers, meta-aramid fibers, and, if present, para-aramid fibers, may each be solution-dyed.

Abstract: A method at an electronic device with a display includes: displaying a user interface having a first region and a second region; receiving, and displaying in the first region of the user interface, a live video stream of a physical environment captured by a remote video camera; displaying, in the second region, a timeline corresponding to a timespan for a first portion of a duration during which the live video stream may have been recorded; in response to receiving a user interaction to move the timespan to a second portion of the duration, transitioning the displayed timeline to a new timeline that corresponds to the timespan for the second portion, and while transitioning, displaying, in the first region, a subset of video frames representing the first and/or second portion of the duration.

Abstract: A drill hole logging system (5) incorporates a computing system (58) at the surface and a deployment mechanism (40) for conveying a logging tool (10) configured to measure one or more geophysical parameters into a drill hole (20). A transmission means (57) communicates commands and data representing the geophysical parameters between the surface computing system and the logging tool. A borehole caliper (300) is employed to profile the inside of the borehole.

Abstract: A method of determining a region of interest in an image of tissue of an individual by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to partition an image of tissue of an individual into a set of areas, identify a tissue type of each area of the image, and apply a classifier to the image to determine a region of interest, the classifier being configured to determine regions of interest based on the tissue types of the set of areas of the image.

Abstract: Systems and methods are provided for facilitating providing power from a power source to security devices. An example method can include receiving a signal informing an occurrence of a security risk event and providing, to a controller, information relating to the occurrence of an event to initiate a security system. The controller may include a power source to charge one or more security devices. The example method can include facilitating providing power from the power source to at least one of the one or more security devices.

Abstract: Disclosed is a method of analysing genetic data about an organism comprising receiving a plurality of input units. Each input unit comprises information about the association between genetic variants in a region of the genome and phenotypes or phenotype combinations. The method comprises carrying out iterations comprising, for each variant determining for which of the phenotypes or phenotype combinations the variant is causal based on the input units. If the variant is causal for phenotypes or phenotype combinations, a sampled effect size is determined of the variant on the phenotypes or phenotype combinations based on the input units and information about correlations between the variants in the region. For each variant, a prediction effect size is determined variant on the phenotypes or phenotype combinations based on an average across the iterations of the sampled effect sizes or of posterior effect sizes calculated using the sampled effect sizes.

Abstract: An apparatus that facilitates search and rescue, for example, in open water. The apparatus comprises a substrate with a particular geometry and a perimeter. The apparatus further comprises a cover positioned atop the substrate with the cover also having a particular geometry and perimeter, which correspond to the geometry and perimeter of the substrate. An air-tight seal seals the substrate perimeter to the cover perimeter and creates a sealed internal region. A liquid-releasable vessel holding an illuminable dye located in the sealed internal region, along with an activator that is also located in the sealed internal region. When the liquid-releasable vessel releases the illuminable dye, the illuminable dye reacts with the activator, thereby resulting in illumination of the illuminable dye. The liquid-releasable vessel comprises an opening with a release mechanism (e.g., clamp, etc.).

Abstract: In one example in accordance with the present disclosure, an electronic device is described. An example electronic device includes a processor to place the electronic device in a transit mode. When in the transit mode, the processor is placed in an inactive state. The example electronic device also includes a wireless module. An example wireless module includes a wireless controller to, when in the transit mode, periodically activate a wireless transceiver of the electronic device. The example wireless module also includes the wireless transceiver to, when in the transit mode 1) connect to a wireless network and 2) transmit configuration information for the electronic device.

Abstract: An ancillary laundry composition comprising an ester oil, which is a polyol comprising at least two ester linkages, free perfume and 0 to 0.85 wt. % anionic and/or cationic surfactant. A method of laundering clothes, wherein said composition is added in the wash or rinse stage. A method of preventing colour fade over (10) laundry cycles, wherein fabrics are treated with said composition during each consecutive laundry cycle. The use of said composition to provide an improved colour maintenance or reduced colour fade over consecutive laundry cycles, preferably (10), more preferably (5) laundry cycles.

Abstract: An aqueous fabric spray composition comprising: an ester oil; and free perfume.

Abstract: An electronic device includes a hand held base assembly that includes circuitry including memory and firmware executed by a processor or microcontroller of the circuitry; and a cartridge assembly that includes memory that is read by the firmware of the handheld base assembly. The cartridge assembly and the handheld base assembly are configured to removably couple together to define the electronic device for producing an aerosol for inhalation by a person. An enclosed air passageway is defined by the cartridge assembly and by the handheld base assembly, which isolates the airflow from the electronics of the device. The enclosed air passageway extends between the opening of the mouthpiece for taking a breath and a diaphragm of the handheld base assembly, movement of the diaphragm changing the air pressure within an enclosed interior space having a pressure sensor for trigging the pressure sensor when a breath is taken.