Abstract: Disclosed herein are therapeutic agents capable of increasing the expression level of ELOVL2. Also described herein are therapeutic agents that reduce or slow an aging phenotype. Methods for treating age-related eye diseases or conditions are also provided. Methods for treating an age-related eye disease or condition in a subject by administering one or more therapeutic agents are provided.

Abstract: Disclosed herein are therapeutic agents capable of increasing the expression level of ELOVL2. Also described herein are therapeutic agents that reduce or slow an aging phenotype. Methods for treating age-related eye diseases or conditions are also provided. Methods for treating an age-related eye disease or condition in a subject by administering one or more therapeutic agents are provided.

Abstract: Disclosed herein are therapeutic agents capable of increasing the expression level of ELOVL2. Also described herein are therapeutic agents that reduce or slow an aging phenotype. Methods for treating age-related eye diseases or conditions are also provided. Methods for treating an age-related eye disease or condition in a subject by administering one or more therapeutic agents are provided.

Abstract: Provided are mutant viral capsid cell libraries, individual cells of such libraries, systems, vectors, and methods for generating the cell libraries, and methods of use thereof to screen for mutant viral capsids with desired characteristics.

Abstract: Provided are mutant viral capsid cell libraries, individual cells of such libraries, systems, vectors, and methods for generating the cell libraries, and methods of use thereof to screen for mutant viral capsids with desired characteristics.

Abstract: Provided are mutant viral capsid cell libraries, individual cells of such libraries, systems, vectors, and methods for generating the cell libraries, and methods of use thereof to screen for mutant viral capsids with desired characteristics.

Abstract: Provided are mutant viral capsid cell libraries, individual cells of such libraries, systems, vectors, and methods for generating the cell libraries, and methods of use thereof to screen for mutant viral capsids with desired characteristics.

Abstract: The present invention involves methods and systems for using electrical stimulation to treat neurological disorders. More particularly, the method comprises surgically implanting an electrical stimulation lead that is in communication with spinal nervous tissue associated with a first, second, or third cervical vertebral segment to result in spinal nervous tissue stimulation, thus treating a wide variety of neurological disorders.

Abstract: The present invention involves methods and systems for using electrical stimulation to treat neurological disorders. More particularly, the method comprises surgically implanting an electrical stimulation lead that is in communication with spinal nervous tissue associated with a first, second, or third cervical vertebral segment to result in spinal nervous tissue stimulation, thus treating a wide variety of neurological disorders.

Abstract: An electrical stimulation system is provided for electrically stimulating nerve tissue in multiple locations in a person's brain to treat multiple conditions in the person's body. The system includes first electrodes and second electrodes adapted to be implanted within a person's skull. The first electrodes are adapted to be positioned proximate first nerve tissue in the brain associated with a first condition in the person's body for delivering electrical stimulation pulses to the first nerve tissue to treat the first condition. The second electrodes are adapted to be positioned proximate second nerve tissue in the brain associated with a second condition in the person's body for delivering electrical stimulation pulses to the second nerve tissue to treat the second condition.

Abstract: According to one aspect, an electrical stimulation system provides modified neuroplasticity effects in a person's nerve tissue. The system includes an electrical stimulation lead adapted for implantation into the person's body for electrical stimulation of target nerve tissue. The stimulation lead includes one or more electrodes adapted to be positioned proximate the target nerve tissue and to deliver electrical stimulation pulses to the target nerve tissue. The system also includes a stimulation source connectable to the stimulation lead and operable to generate the electrical stimulation pulses for transmission to the one or more electrodes of the stimulation lead to cause the one or more electrodes to deliver the electrical stimulation pulses to the target nerve tissue to modify neuroplasticity effects in the target nerve tissue.

Abstract: According to one embodiment, a system for stimulating peripheral nerves in a painful upper chest region of a person's body is provided. The system includes stimulation electrodes adapted to be implanted in tissue proximate a network of peripheral nerve fibers located in and innervating the painful upper chest region and to deliver electrical stimulation pulses to the network of peripheral nerve fibers located in and innervating the painful upper chest region. The system also includes a stimulation source adapted for implantation into the person's body and operable to generate electrical stimulation pulses for transmission to the electrodes for delivery to the network of peripheral nerve fibers located in and innervating the painful upper chest region to relieve pain in the painful upper chest region. The stimulation pulses are specifically tailored to relieve pain in the painful upper chest region.

Abstract: According to one embodiment, a system for stimulating peripheral nerves in a painful region of a person's limb is provided. The system includes stimulation electrodes adapted to be implanted in tissue proximate a network of peripheral nerve fibers located in and innervating the painful region of the person's limb and to deliver electrical stimulation pulses to the network of peripheral nerve fibers located in and innervating the painful region. The system also includes a stimulation source adapted for implantation into the person's body and operable to generate electrical stimulation pulses for transmission to the electrodes for delivery to the network of peripheral nerve fibers located in and innervating the painful region of the person's limb to relieve pain in the painful region. The stimulation pulses are specifically tailored to relieve pain in the painful region. In a more particular embodiment, the painful region is a region of an arm, leg, hand, or foot that has experienced trauma.

Abstract: According to one embodiment, a system for neurological stimulation of peripheral nerve fibers to treat low back pain is provided. The system includes stimulation electrodes adapted to be implanted in tissue proximate a network of peripheral nerve fibers located in and innervating a painful region of the low back area and to deliver electrical stimulation pulses to the network of peripheral nerve fibers located in and innervating the painful region of the low back area. The system also includes a stimulation source adapted for implantation into the person's body and operable to generate electrical stimulation pulses for transmission to the electrodes for delivery to the network of peripheral nerve fibers located in and innervating the painful region of the low back area to relieve pain in the painful region of the low back area.

Abstract: According to one aspect, an electrical stimulation system provides reduced neuroplasticity effects in a person's nerve tissue. The system includes an electrical stimulation lead adapted for implantation into the person's body for electrical stimulation of target nerve tissue. The lead includes a number of electrodes adapted to be positioned near the target nerve tissue and to deliver electrical stimulation energy to the target nerve tissue. The system also includes a stimulation source connectable to the lead and operable to generate signals for transmission to the electrodes of the lead to cause the electrodes to deliver electrical stimulation energy to the target nerve tissue to reduce neuroplasticity effects.