Abstract: Devices, systems, and methods for controlling the operation of a focused ultrasound blood-brain barrier opening (FUS-BBBO) device using an individualized closed-loop feedback control method are disclosed. Devices, systems, and methods for performing transcranial cavitation localization using a time difference of arrival method combined with signal processing using differential cavitation are also disclosed. Methods for performing a liquid biopsy to diagnose a brain disorder using a FUS-BBBO method to enhance the release of biomarkers from the brain into CSF and blood are also disclosed.

Abstract: Map and kinematic based predictions are used for determining the trajectory of road users for use by a host vehicle. A kinematic trajectory of a road user is determined. The road user is associated with mapped lanes. At least one path of the road user is predicted using the mapped lanes. For a path of the at least one path, a probability is generated using the kinematic trajectory of the road user, wherein the probability represents how likely the road user will continue following the path. A kinematic prediction of the road user is generated using the probability corresponding to the path, wherein the kinematic prediction represents how likely the road user will follow an alternative path to the at least one path. Using at least one control system of a vehicle, a control action for the vehicle is determined using the at least one path and the kinematic prediction.

Abstract: Described herein are systems and techniques for improving an accuracy of determinations made using data sensed in a wellbore or in a laboratory. Nuclear magnetic resonance (NMR) sensing devices may be used to collect data in a wellbore or lab. NMR sensing devices include a magnet (e.g., a permanent magnet or electromagnet) that provides a magnetic field that aligns the spins of protons in substances near the NMR sensing device. The magnetic field strength provided by the magnet of the NMR sensing device affects the sensitivity of the NMR sensing device and affects frequencies that the NMR sensing device effectively uses when the NMR sensing device operates. Systems and techniques of the present disclosure may measure concentrations of lithium in brine deposits when identifying particular brine deposits that include sufficient lithium concentrations to justify extracting lithium from those particular brine deposits.

Abstract: Described herein is a graphics processor comprising an instruction cache and a plurality of processing elements coupled with the instruction cache. The plurality of processing elements include functional units configured to provide an integer pipeline to execute instructions to perform operations on integer data elements. The integer pipeline including a first multiplier and a second multiplier, the first multiplier and the second multiplier configured to execute operations for a single instruction.

Abstract: Described herein is a graphics processor comprising a memory interface and a graphics processing cluster coupled with the memory interface. The graphics processing cluster includes a plurality of processing resources. A processing resource of the plurality of processing resources includes a source crossbar communicatively coupled with a register file, the source crossbar to reorder data elements of a source operand and a format conversion pipeline to convert a plurality of input data elements specified by the source operand from a first format of a plurality of datatype formats to a second format of the plurality of datatype formats, the plurality of datatype formats including integer and floating-point formats.

Abstract: Described herein is a graphics processor comprising a memory interface and a graphics processing cluster coupled with the memory interface. The graphics processing cluster includes a multi-lane parallel floating-point unit and a multi-lane parallel integer unit. The multi-lane parallel integer unit includes an integer pipeline including a plurality of parallel integer logic units configured to perform integer compute operations on a plurality of input data elements and a format conversion pipeline including a plurality of parallel format conversion units configured to convert a plurality of input data elements from a first one of a plurality of datatype formats to a second one of the plurality of datatype formats, the plurality of datatype formats including integer and floating-point formats.

Abstract: A method for generating a dense light detection and ranging (LiDAR) representation by a vision system of a vehicle includes generating, at a depth estimation network, a depth estimate of an environment depicted in an image captured by an image capturing sensor integrated with the vehicle. The method also includes generating, via a sparse depth network, one or more sparse depth estimates of the environment, each sparse depth estimate associated with a respective sparse representation of one or more sparse representations. The method further includes generating the dense LiDAR representation based on a dense depth estimate that is generated based on the depth estimate and the one or more sparse depth estimates. The method still further includes controlling an action of the vehicle based on the dense LiDAR representation.

Abstract: A method for forming a composite tread, the method comprising the steps of: forming a coextruded strip of a first compound and a second compound, wherein the first compound is a tread compound, and the second compound is formed from a second compound, wherein the tread is formed from winding the coextruded strip onto the tire building drum while varying the ratio of the first compound to the second compound.

Abstract: A method of forming an electrospun prosthetic valve includes utilizing a rotatable and angularly adjustable prosthetic valve mold. The prosthetic valve mold is set to a first angle. The prosthetic valve mold is rotated at a first rotational velocity and a first layer of electrospun fibers is deposited on the prosthetic valve mold. The prosthetic valve mold is stopped and a frame is positioned over the first layer. The prosthetic valve mold is set to a second angle. The prosthetic valve mold is rotated at a second velocity and a second layer of electrospun fibers is deposited on an outer surface of the first layer and an outer surface of the frame.

Abstract: The present invention relates to methods for separating enantiomers of 5-phenyl and 5-naphthyl substituted 4-(aminomethyl)-6-(1-methyl-1H-pyrazol-4-yl)phthalazin-1(2H)-ones using N-Boc-L-phenylalanine, N-Boc-D-phenylalanine, and similar chiral acids.

Abstract: Feature engineering, for example, in automated machine learning, can include receiving streaming data representing at least one attribute detected by a sensor over time. Long term point statistics associated with the streaming data can be computed. The streaming data can be quantized into intervals of time windows and short term point statistics based on the intervals can be computed. The long term point statistics and the short term point statistics can be normalized. Dynamic time warping can be applied across the normalized long term point statistics and short term point statistics. A pair of probability distributions can be generated associated with the dynamic time warped normalized long term point statistics and short term point statistics. Based on distance between the mean values of the probability distributions, machine learning input features can be produced. The machine learning input features can be fed to train a machine learning model for detecting anomaly.

Abstract: Systems, methods, and computer-readable media for analyzing health information to generate medical assessments are described. Health information may include any type of information associated with the health or physical characteristics of a patient. Non-limiting examples of medical assessments include medical diagnoses, medical orders, and risk assessments. A health information analysis system may access health information associated with a patient and provide a medical assessment based on various analyses of the health information. The health information analysis system may receive feedback associated with the medical assessments, such as historical information and/or user input regarding the accuracy or completeness of the medical assessment. The feedback may be used by the health information analysis system to update the analyses of the health information.

Abstract: The present disclosure relates generally to the field of neurology. In particular, the disclosure relates to a method of detecting a neurodegenerative disease in a subject and methods of treatment thereof. The methods include detecting the level of an exosome-bound aggregated biomarker in a sample obtained from the subject, wherein an increased level of the exosome-bound aggregated biomarker as compared to a reference indicates that the subject is suffering from a neurodegenerative disease. Also described are methods for detecting a subject at risk of developing amyloidosis or a neurodegenerative disease, methods for detecting and treating amyloidosis or a neurodegenerative disease in a subject, and methods of determining the aggregation state of a biomarker in a sample.

Abstract: The disclosed embodiments provide techniques for scoring a driver or vehicle. In one embodiment, a method is disclosed comprising receiving metrics associated with a vehicle; generating a deviation vector based on the metrics and a plurality of aggregated values corresponding to the metrics; computing a driver update value based on the deviation vector and a plurality of model parameters, each of the plurality of model parameters corresponding to the metrics; and computing a driver score based on the driver update value, a previous score, and a learning rate.

Abstract: Disclosed is an apparatus for pretreatment of printable fabrics, comprising a washer/extractor; a control apparatus connected to the washer/extractor to control said washer/extractor; and a source of pretreatment chemicals to be added to the washer/extractor in a controlled manner by the control apparatus. Also disclosed are methods of pretreating fabrics using the disclosed apparatus.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for detecting sources of computer network failures. One of the methods includes identifying a network flow in a computer network between a source and a destination; performing a first probe to determine whether there is end-to-end connectivity between the source and the destination; in response to determining that there is no end-to-end connectivity between the host and the destination, performing one or more additional probes including a second probe to determine whether each hop in the path of the network flow between the source and the destination is operational including requesting that the source transmit a respective first trace diagnostic packet to each hop in the path of the network flow; and determining whether at least one link of the computer network that is part of the path of the network flow has failed based on the results.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for detecting sources of computer network failures. One of the methods includes identifying a network flow in a computer network between a source and a destination; performing a first probe to determine whether there is end-to-end connectivity between the source and the destination; in response to determining that there is no end-to-end connectivity between the host and the destination, performing one or more additional probes including a second probe to determine whether each hop in the path of the network flow between the source and the destination is operational including requesting that the source transmit a respective first trace diagnostic packet to each hop in the path of the network flow; and determining whether at least one link of the computer network that is part of the path of the network flow has failed based on the results.

Abstract: Disclosed is a process for printing on cotton fabric comprising (1) contacting cotton fabric with an aqueous solution comprising (A) 40% to 70% by weight of at least one multivalent cationic salt; (B) optionally 0.1% to 5% by weight of a blocked isocyanate crosslinking agent, and (C) 3% to 40% by weight of a waterborne resin, all percentages based on the weight of the aqueous solution; (2) drying the cotton fabric to remove the water from the cotton fabric; and (3) digitally printing the pretreated and coated cotton fabric with a water-based textile ink.

Abstract: Disclosed is a process for printing on polyester fabric comprising (1) contacting polyester fabric with an aqueous solution comprising (A) 5% to 35% by weight of at least one multivalent cationic salt; (B) 0.1% to 5% by weight of a blocked polyisocyanate crosslinking agent, and (C) 3% to 40% by weight of a waterborne resin, all percentages based on the weight of the aqueous solution; (2) drying the polyester fabric to remove the water from the polyester fabric; and (3) digitally printing the pretreated and coated polyester fabric with a water-based textile ink.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for detecting sources of computer network failures. One of the methods includes identifying a network flow in a computer network between a source and a destination; performing a first probe to determine whether there is end-to-end connectivity between the source and the destination; in response to determining that there is no end-to-end connectivity between the host and the destination, performing one or more additional probes including a second probe to determine whether each hop in the path of the network flow between the source and the destination is operational including requesting that the source transmit a respective first trace diagnostic packet to each hop in the path of the network flow; and determining whether at least one link of the computer network that is part of the path of the network flow has failed based on the results.