Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: The present disclosure is directed to a software tool that facilitates the presentation of a three-dimensional view of a construction project as well as the generation of various types of two-dimensional technical drawings based on this three-dimensional view. In one implementation, the software tool causes a computing device to engage in the following operations. The computing device may receive an indication of a desired clip height of a three-dimensional view at which to generate a two-dimensional technical drawing; identify a subset of meshes that intersect with a two-dimensional plane at the desired clip height; determine respective portions of each mesh that intersect the two-dimensional plane at the desired clip height; compile a dataset that defines the two-dimensional drawing; and render the two-dimensional drawing using the compiled dataset.

Abstract: A storage, retrieval and processing system for processing objects is disclosed.

Abstract: An object processing system is disclosed that includes a plurality of track sections, and a plurality of remotely actuatable carriers for controlled movement along at least portions of the plurality of track sections, each of the actuatable carriers being instructed at any time to move a limited number of track section only.

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: A maintenance system is disclosed for assisting in maintaining an automated carrier system for moving objects to be processed. The maintenance system includes a plurality of automated carriers that are adapted to move on an array of discontinuous standard track sections, each said automated carrier including a carrier body that is no larger in either a length or width direction that a standard track section, and an automated maintenance carrier that is adapted to move on the array of discontinuous track sections, said automated maintenance system including a maintenance body that is larger in at least one of a length or width direction than the standard track section.

Abstract: A storage, retrieval and processing system for processing objects is disclosed. The storage, retrieval and processing system includes a plurality of storage bins providing storage of a plurality of objects, where the plurality of storage bins is in communication with a bin conveyance system for moving selected storage bins to a storage bin processing location, a programmable motion device in communication with the bin processing location for receiving a selected storage bin from the plurality of bins, where the programmable motion device includes an end effector for grasping and moving a selected object out of a selected storage bin, and a plurality of destination bins in communication with the bin conveyance system for moving a selected destination bin from a destination bin processing location that is proximate the programmable motion device to the plurality of destination bins.

Abstract: A storage, retrieval and processing system is disclosed for processing objects. The system includes a plurality of bins including objects to be distributed by the processing system, said plurality of bins being provided in at least a partially generally circular arrangement, a programmable motion device that includes an end effector for grasping and moving any of the objects, said programmable motion device being capable of reaching any of the objects within the plurality of bins, and a plurality of destination containers for receiving any of the objects from the plurality of bins, said plurality of destination containers being provided in a region that is generally within the at least partially generally circular arrangement of the plurality of bins.

Abstract: An image-guided robotic intervention system (“IGRIS”) may be used to perform medical procedures on patients. IGRIS provides a real-time view of patient anatomy, as well as an intended target or targets for the procedures, software that allows a user to plan an approach or trajectory path using either the image or the robotic device, software that allows a user to convert a series of 2D images into a 3D volume, and localizes the 3D volume with respect to real-time images during the procedure. IGRIS may include sensors to estimate pose of the imaging device relative to the patient to improve the performance of that software with respect to runtime, robustness, and accuracy.

Abstract: An image-guided robotic intervention system (“IGRIS”) may be used to perform medical procedures on patients. IGRIS provides a real-time view of patient anatomy, as well as an intended target or targets for the procedures, software that allows a user to plan an approach or trajectory path using either the image or the robotic device, software that allows a user to convert a series of 2D images into a 3D volume, and localizes the 3D volume with respect to real-time images during the procedure. IGRIS may include sensors to estimate pose of the imaging device relative to the patient to improve the performance of that software with respect to runtime, robustness, and accuracy.

Abstract: An image-guided robotic intervention system (“IGRIS”) may be used to perform medical procedures on patients. IGRIS provides a real-time view of patient anatomy, as well as an intended target or targets for the procedures, software that allows a user to plan an approach or trajectory path using either the image or the robotic device, software that allows a user to convert a series of 2D images into a 3D volume, and localizes the 3D volume with respect to real-time images during the procedure. IGRIS may include sensors to estimate pose of the imaging device relative to the patient to improve the performance of that software with respect to runtime, robustness, and accuracy.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media for evaluating and improving live translation captioning systems. An exemplary method includes: displaying a word in a first language; receiving a first audio sequence, the first audio sequence comprising a verbal description of the word; generating a first translated text in a second language; displaying the first translated text; receiving a second audio sequence, the second audio sequence comprising a guessed word based on the first translated text; generating a second translated text in the first language; determining a matching score between the word and the second translated text; determining a performance score of the live translation captioning system based on the matching score.

Abstract: An image-guided robotic intervention system (“IGRIS”) may be used to perform medical procedures on patients. IGRIS provides a real-time view of patient anatomy, as well as an intended target or targets for the procedures, software that allows a user to plan an approach or trajectory path using either the image or the robotic device, software that allows a user to convert a series of 2D images into a 3D volume, and localizes the 3D volume with respect to real-time images during the procedure. IGRIS may include sensors to estimate pose of the imaging device relative to the patient to improve the performance of that software with respect to runtime, robustness, and accuracy.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media for evaluating and improving live translation captioning systems. An exemplary method includes: displaying a word in a first language; receiving a first audio sequence, the first audio sequence comprising a verbal description of the word; generating a first translated text in a second language; displaying the first translated text; receiving a second audio sequence, the second audio sequence comprising a guessed word based on the first translated text; generating a second translated text in the first language; determining a matching score between the word and the second translated text; determining a performance score of the live translation captioning system based on the matching score.

Abstract: An image-guided robotic intervention system (“IGRIS”) may be used to perform medical procedures on patients. IGRIS provides a real-time view of patient anatomy, as well as an intended target or targets for the procedures, software that allows a user to plan an approach or trajectory path using either the image or the robotic device, software that allows a user to convert a series of 2D images into a 3D volume, and localizes the 3D volume with respect to real-time images during the procedure. IGRIS may include sensors to estimate pose of the imaging device relative to the patient to improve the performance of that software with respect to runtime, robustness, and accuracy.

Abstract: Desired vehicle destinations may be determined from spoken dialogs. A speech input may be received from a user through a voice user interface. Current utterance variables may be obtained by tokenizing the user speech input. One or more of a plurality of utterance templates for a reply to the user speech input may be determined by a trained automatic agent based on the plurality of current utterance variables. One of a plurality of Application Programming Interfaces (API) to call and one or more parameters for the API to call with may be determine by the trained automatic agent based on the plurality of current utterance variables. A response may be obtained from the API call. A context string for the reply to the user speech input by the trained automatic agent may be constructed based on the utterance templates and the response of the API call.

Abstract: Methods for screening, diagnosing, or predicting presence, progression, or treatment effects of a cognitive dysfunction such as dementia based on an analysis of drawing behavior changes by a pre-trained Naïve Bayes method are provided. The methods include steps of obtaining drawing data of at least one image created by a test subject on a digital device and obtaining personal data of the test subject; reconstructing the at least one image based on the drawing data obtained; converting the drawing data to drawing features comprising a plurality of motion features and a plurality of geometric features; and determining probability that the test subject has a cognitive dysfunction based on the drawing features and the personal data by a pre-trained Naïve Bayes method with a greedy variable selection.

Abstract: The invention is related to a shaded porcelain system that contains two types of veneering porcelains: natural enamel/dentin body and opal enamel, as well as stain & glaze porcelain, with CTE that are compatible to and which can be used for veneering a dental prosthesis made of 1) lithium disilicate-based glass-ceramic substructure that is formed by hot pressing or CAD/CAM machined process or 2) YTZP zirconia-based ceramic substructure that is formed by CAD/CAM machined process in order to improve overall esthetics of final prosthesis.