Patents by Inventor Christopher CHUMSAE

Christopher CHUMSAE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN PURIFICATION METHODS TO REDUCE ACIDIC SPECIES
    Publication number: 20190062419
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.
    Type: Application
    Filed: April 12, 2018
    Publication date: February 28, 2019
    Applicant: AbbVie Inc.
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew Omon HERIGSTAD, Hong YANG, Christopher CHUMSAE
  • CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES
    Publication number: 20170355761
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
    Type: Application
    Filed: May 22, 2017
    Publication date: December 14, 2017
    Applicant: AbbVie Inc.
    Inventors: Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Christopher CHUMSAE
  • LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20170158758
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: November 22, 2016
    Publication date: June 8, 2017
    Applicant: AbbVie, Inc.
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew HERIGSTAD, Hong YANG, Kartik SUBRAMANIAN, Xiaobei ZENG, Diane D. DONG, Wen Chung LIM, Kathreen A. GIFFORD, Zehra KAYMAKCALAN, Christopher CHUMSAE
  • PROTEIN PURIFICATION METHODS TO REDUCE ACIDIC SPECIES
    Publication number: 20160251425
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.
    Type: Application
    Filed: May 9, 2016
    Publication date: September 1, 2016
    Applicant: ABBVIE INC.
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew Omon HERIGSTAD, Hong YANG, Christopher CHUMSAE
  • LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20160194390
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: January 28, 2016
    Publication date: July 7, 2016
    Applicant: AbbVie, Inc.
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew Omon HERIGSTAD, Hong YANG, Kartik SUBRAMANIAN, Xiaobei ZENG, Diane D. DONG, Wen Chung LIM, Kathreen A. GIFFORD, Zehra KAYMAKCALAN, Christopher CHUMSAE
  • CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES
    Publication number: 20160145331
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
    Type: Application
    Filed: January 28, 2016
    Publication date: May 26, 2016
    Applicant: AbbVie Inc.
    Inventors: Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Christopher CHUMSAE
  • LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20150166650
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: December 29, 2014
    Publication date: June 18, 2015
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew Omon HERIGSTAD, Hong YANG, Kartik SUBRAMANIAN, Xiaobei ZENG, Diane D. DONG, Wen Chung LIM, Kathreen A. GIFFORD, Zehra KAYMAKCALAN, Christopher CHUMSAE
  • PROTEIN PURIFICATION METHODS TO REDUCE ACIDIC SPECIES
    Publication number: 20150141623
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.
    Type: Application
    Filed: December 29, 2014
    Publication date: May 21, 2015
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew Omon HERIGSTAD, Hong YANG, Christopher CHUMSAE
  • LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20150132801
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: December 18, 2014
    Publication date: May 14, 2015
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew Omon HERIGSTAD, Hong YANG, Kartik SUBRAMANIAN, Xiaobei ZENG, Diane D. DONG, Wen Chung LIM, Kathreen A. GIFFORD, Zehra KAYMAKCALAN, Christopher CHUMSAE
  • MODULATED LYSINE VARIANT SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20150110775
    Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: November 12, 2013
    Publication date: April 23, 2015
    Inventors: Kartik SUBRAMANIAN, Mayda PEREZ THIELE, Xiaobei ZENG, Chee Furng WONG, Zehra KAYMAKCALAN, Ying JING, Christopher CHUMSAE
  • LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20150110799
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: November 12, 2013
    Publication date: April 23, 2015
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew Omon HERIGSTAD, Hong YANG, Kartik SUBRAMANIAN, Xiaobei ZENG, Diane D. DONG, Wen Chung LIM, Kathreen A. GIFFORD, Zehra KAYMAKCALAN, Christopher CHUMSAE