Abstract: The technology disclosed provides systems and methods that display database objects representing entities, placement channels and workflow status in an insurance or other risk transfer program. Specially coded distribution trees and graphs of nodes represent the overall flow and, optionally, status of placement workflows. Node and edge data generated for display depicts multiple risk placements on behalf of at least one requesting party through intermediaries to responding parties. Line width of edges represents calculated relative size of placements, and pattern, style, and color of edges can depict statuses of the risk placements. Another geo-coded map display also depicts as nodes a requesting party, intermediaries and responding parties, connected by edges that represent communication channels.

Abstract: Early detection of lysosomal storage diseases (LSDs) including Mucopolysaccharidosis Type I (MPS I) and Pompe Disease can greatly improve patient outcome as each disease can be fatal once symptoms emerge. Screening for MPS I and Pompe Disease using biological samples including dried blood spots (DBS), buccal swab, peripheral blood mononuclear cells (PBMCs), or white blood cells (WBCs) is described. The disclosed methods and assays provide a robust way to screen newborns for LSDs. The disclosed methods and assays can also allow rapid prediction of whether a patient with LSD will develop an immune response to enzyme replacement therapy (ERT), thus improving treatment for patients with LSDs. The disclosed methods and assays can also further reduce the number of false positives caused by pseudo deficiency cases of LSD, such as MPS I and Pompe Disease.

Abstract: A shampoo composition comprising i) 0.9 to 2 wt % of an alkali metal salt of an aldonic acid, which is sodium gluconate; ii) 0.1 to 2 wt %, citric acid by weight of the total composition; and iii) an anionic surfactant; iv) a preservative, which is sodium benzoate; and wherein the composition has a pH of from 3 to 5, provides repair to damaged internal protein of hair.

Abstract: A battery interconnect may include a desired current capacity, integrated fusible links, and be manufacturable using cost effective techniques. In some embodiments, a battery interconnect includes a busbar and relatively thinner links. A busbar carries larger currents and accordingly its cross-sectional areas are relatively larger to reduce ohmic losses. A link carries a much smaller current, and a fusible link is configured to break the circuit when the current is above a threshold, thus requiring a relatively small cross-sectional area. These sometime disparate length scales are addressed using several techniques such as layering a busbar and a foil sheet and pressing portions of a busbar to form the links. The links can be affixed to a plurality of battery cells to connect the cells in parallel or series.

Abstract: An inflatable unit load device that is used to deploy cargo from an aircraft is described herein. In some instances, the inflatable unit load device may include a bladder having one or more inflatable interior bladder cells and a top surface, the top surface of the bladder forming a rigid support surface when the bladder is inflated on which cargo can be loaded, an outer material that positions the one or more inflatable interior bladder cells of the bladder, and a cargo retaining system that retains the cargo on the top surface.

Abstract: A sensor hub for collecting sensor data during a parachuting or wing-suite event is described herein. In some instances, the sensor hub may include a sensor hub housing, the sensor hub housing including a first cavity that houses a power supply and a communication unit and a second cavity that houses a location sensor and an orientation sensor, wherein the communication unit is configured to share the location sensor and the orientation sensor with a second sensor hub and a helmet that attaches to the sensor hub housing.

Abstract: An air delivery barrel system is described, the air delivery barrel system includes a strap system that provides line stretch of the strap system when a force is exerted on the strap system, the strap system including a continuous strap, a first barrel, the first barrel being formed out of a cylindrically shaped wall and the cylindrically shaped wall including a channel that the strap system passes through, an end cap, the end cap being detachably connectable to a bottom end of the first barrel, the end cap protecting a bottom portion of the strap system, a lid, the lid being detachably connectable to a top end of the first barrel, the lid including a recess through which the strap system passes through, and a second barrel that can be situated within the first barrel and the cylindrically shaped wall of the first barrel protects the second barrel.

Abstract: A high frequency data recorder (“HFDR”) can include a first set of contacts, on a first side of the HFDR, that are pluggable into a first meter receptacle of a meter box, wherein the first meter receptacle provides a connection to a power supply and a connection to a load. The HFDR also includes a second set of contacts, on a second side of the HFDR, that form a second meter receptacle. The second meter receptacle provides another connection to the power supply and another connection to the load. The HFDR can further include a processor that accesses a non-transitory machine readable memory that stores instruction that when executed cause the processor to passively measures current downstream from the meter box. The HFDR still further includes a wireless transceiver that wirelessly transmits data characterizing the measured current.

Abstract: The current disclosure provides antibodies that bind to peptides associated with the primary immunodeficiency disorders (PIDD) Wiskott-Aldrich Syndrome (WAS) and X-linked agammaglobulinemia (XLA). The antibodies can be used in peptide immunoaffinity enrichment coupled to selected reaction monitoring mass spectrometry (immuno-SRM) assays for clinical diagnosis and newborn screening of WAS and XLA, among other uses.

Abstract: The technology disclosed provides systems and methods that display database objects representing entities, placement channels and workflow status in an insurance or other risk transfer program. Specially coded distribution trees and graphs of nodes represent the overall flow and, optionally, status of placement workflows. Node and edge data generated for display depicts multiple risk placements on behalf of at least one requesting party through intermediaries to responding parties. Line width of edges represents calculated relative size of placements, and pattern, style, and color of edges can depict statuses of the risk placements. Another geo-coded map display also depicts as nodes a requesting party, intermediaries and responding parties, connected by edges that represent communication channels.

Abstract: An automated system for administering food to laboratory animals housed in aquatic tanks includes a plurality of individual feeding units that independently communicate with a common feed management hub. Each feeding unit includes a rack for holding a collection of aquatic tanks and a wireless robotic feeder configured to move in three dimensions relative to the rack. The robotic feeder precisely meters and delivers liquid and/or dry food to each rack-mounted tank in accordance with user-modifiable feed schedules which are maintained by the feed management hub. To compensate for any adjustments to the particular arrangement of tanks within a feeding unit, the robotic feeder periodically scans the rack for tanks and transmits the scan data back to the feed management hub. Accordingly, the feed management hub ensures that the proper type of food is accurately and timely delivered to each aquatic tank in compliance with the stored feed schedules.

Abstract: A sensor hub for collecting sensor data during a parachuting or wing-suite event is described herein. In some instances, the sensor hub may include a sensor hub housing, the sensor hub housing including a first cavity that houses a power supply and a communication unit and a second cavity that houses a location sensor and an orientation sensor, wherein the communication unit is configured to share the location sensor and the orientation sensor with a second sensor hub and a helmet that attaches to the sensor hub housing.

Abstract: An air delivery barrel system is described, the air delivery barrel system includes a strap system that provides line stretch of the strap system when a force is exerted on the strap system, the strap system including a continuous strap, a first barrel, the first barrel being formed out of a cylindrically shaped wall and the cylindrically shaped wall including a channel that the strap system passes through, an end cap, the end cap being detachably connectable to a bottom end of the first barrel, the end cap protecting a bottom portion of the strap system, a lid, the lid being detachably connectable to a top end of the first barrel, the lid including a recess through which the strap system passes through, and a second barrel that can be situated within the first barrel and the cylindrically shaped wall of the first barrel protects the second barrel.

Abstract: A gas compressor is disclosed that includes a first rotor having a first rotor body, the first rotor body including a plurality of helical lobes, an infernal volume within the first rotor body defined by a wall, and a turbine disposed within the internal volume, the turbine including a turbine body and a plurality of airfoils extending substantially radially from the turbine body to the wall, where the internal volume is structured to enable a cooling fluid to flow therethrough. The gas compressor further includes a second rotor body including a plurality of helical flutes, an inlet manifold and an outlet manifold, both disposed within the second rotor body, and a body channel within at least one flute extending from and in fluid communication with the inlet manifold to the outlet manifold, where the body channel is structured to enable a cooling fluid to flow therethrough.

Abstract: Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes of the various embodiments of the present invention.

Abstract: A method and system for creating a point cloud are disclosed. A first image is captured by a first camera sensor and a second image is captured by a second camera sensor. The first and the second image have an area of overlap. Location of the first camera relative to the second camera is predetermined and each of the first and the second camera is having a field of view of more than 180 degrees. Based on the area of overlap, the first and the second image are stitched to create a composite stitched image. In one aspect, depth information from the area of overlap is extracted based on the predetermined location and a point cloud is created from otherwise to be discarded image data in the area of overlap.

Abstract: A method may include defining, based on one or more user inputs, a custom type including one or more fields having one or more capabilities. In response to a first request from a publish service, the custom type may be sent to the publish service such that the publish service publishes, to a search system, one or more documents in accordance with a schema specified by the custom type. In response to a second request from a search service, a response may be sent to the search service identifying one or more field names and/or methods at the search system that correspond to one or more fields and/or actions specified by a first query received at the search service. The one or more field names and/or methods may be identified based at least on the custom type. Related systems and articles of manufacture, including computer program products, are also provided.

Abstract: A gas compressor is disclosed that includes a first rotor having a first rotor body, the first rotor body including a plurality of helical lobes, an infernal volume within the first rotor body defined by a wall, and a turbine disposed within the internal volume, the turbine including a turbine body and a plurality of airfoils extending substantially radially from the turbine body to the wall, where the internal volume is structured to enable a cooling fluid to flow therethrough. The gas compressor further includes a second rotor body including a plurality of helical flutes, an inlet manifold and an outlet manifold, both disposed within the second rotor body, and a body channel within at least one flute extending from and in fluid communication with the inlet manifold to the outlet manifold, where the body channel is structured to enable a cooling fluid to flow therethrough.

Abstract: A method and system for creating a point cloud are disclosed. A first image is captured by a first camera sensor and a second image is captured by a second camera sensor. The first and the second image have an area of overlap. Location of the first camera relative to the second camera is predetermined and each of the first and the second camera is having a field of view of more than 180 degrees. Based on the area of overlap, the first and the second image are stitched to create a composite stitched image. In one aspect, depth information from the area of overlap is extracted based on the predetermined location and a point cloud is created from otherwise to be discarded image data in the area of overlap.

Abstract: A method may include defining, based on one or more user inputs, a custom type including one or more fields having one or more capabilities. In response to a first request from a publish service, the custom type may be sent to the publish service such that the publish service publishes, to a search system, one or more documents in accordance with a schema specified by the custom type. In response to a second request from a search service, a response may be sent to the search service identifying one or more field names and/or methods at the search system that correspond to one or more fields and/or actions specified by a first query received at the search service. The one or more field names and/or methods may be identified based at least on the custom type. Related systems and articles of manufacture, including computer program products, are also provided.