Patents by Inventor Christopher Cottrell
Christopher Cottrell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240233873Abstract: Provided herein are methods for discovery of epitope specific monoclonal antibodies to pathogens directly from immune sera for immunotherapeutic use. Further provided herein are methods to determine molecular structure of antibodies targeting an antigen from convalescent or vaccinated individuals for the purpose of rational vaccine design.Type: ApplicationFiled: February 24, 2022Publication date: July 11, 2024Inventors: Andrew B. Ward, Aleksandar Antanasijevic, Charles Bowman, Christopher Cottrell, Gabriel Ozorowski, Robert Kirchdoerfer
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Publication number: 20240136019Abstract: Provided herein are methods for discovery of epitope specific monoclonal antibodies to pathogens directly from immune sera for immunotherapeutic use. Further provided herein are methods to determine molecular structure of antibodies targeting an antigen from convalescent or vaccinated individuals for the purpose of rational vaccine design.Type: ApplicationFiled: February 24, 2022Publication date: April 25, 2024Inventors: Andrew B. Ward, Aleksandar Antanasijevic, Charles Bowman, Christopher Cottrell, Gabriel Ozorowski, Robert Kirchdoerfer
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Patent number: 11964010Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.Type: GrantFiled: March 8, 2021Date of Patent: April 23, 2024Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Scripps Research Institute, Trustees of Dartmouth CollegeInventors: Barney Graham, Jason Mclellan, Andrew Ward, Robert Kirchdoerfer, Christopher Cottrell, Michael Gordon Joyce, Masaru Kanekiyo, Nianshuang Wang, Jesper Pallesen, Hadi Yassine, Hannah Turner, Kizzmekia Corbett
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Publication number: 20230190914Abstract: The invention relates to germline-targeting designs, stabilization designs, and/or combinations thereof, of proteins designed with modified surfaces helpful for immunization regimens, other protein modifications and/or development of nanoparticles, methods of making and using the same, and to (a) germline-targeting priming or boosting/shepherding immunogens to initiate or guide maturation of VRC01-class responses (b) PCT64/PG9-germline-targeting designs (c) BG18-germline-targeting designs or boosting/shepherding immunogens to initiate or guide maturation of BG18-like responses, and/or (d) trimer stabilization and presentation in a membrane-bound format.Type: ApplicationFiled: October 24, 2022Publication date: June 22, 2023Inventors: William SCHIEF, Manyuan MA, Jon STEICHEN, Xiaozhen HU, Sebastian RAEMISCH, Alessia LIGUORI, Torben SCHIFFNER, Jordan WILLIS, Christopher COTTRELL
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Publication number: 20210275664Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.Type: ApplicationFiled: March 8, 2021Publication date: September 9, 2021Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, The Scripps Research Institute, Trustees of Dartmouth CollegeInventors: Barney Graham, Jason McLellan, Andrew Ward, Robert Kirchdoerfer, Christopher Cottrell, Michael Gordon Joyce, Masaru Kanekiyo, Nianshuang Wang, Jesper Pallesen, Hadi Yassine, Hannah Turner, Kizzmekia Corbett
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Patent number: 10960070Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.Type: GrantFiled: October 25, 2017Date of Patent: March 30, 2021Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Scripps Research Institute, Trustees of Dartmouth CollegeInventors: Barney Graham, Jason McLellan, Andrew Ward, Robert Kirchdoerfer, Christopher Cottrell, Michael Gordon Joyce, Masaru Kanekiyo, Nianshuang Wang, Jesper Pallesen, Hadi Yassine, Hannah Turner, Kizzmekia Corbett
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Publication number: 20200061185Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.Type: ApplicationFiled: October 25, 2017Publication date: February 27, 2020Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, The Scripps Research Institute, Trustees of Dartmouth CollegeInventors: Barney Graham, Jason McLellan, Andrew Ward, Robert Kirchdoerfer, Christopher Cottrell, Michael Gordon Joyce, Masaru Kanekiyo, Nianshuang Wang, Jesper Pallesen, Hadi Yassine, Hannah Turner, Kizzmekia Corbett
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Patent number: 9952908Abstract: A first party, such as a residential subscriber to an Internet Service Provider (ISP), logically partitions its computing resources into an end user partition and a crowd sourced cloud partition. The first party installs a crowd sourced cloud application in each cloud partition. Together, a cloud provider computing system and each cloud application orchestrate cloud services over a communications network, such as the Internet. For each crowd sourced cloud application, orchestration involves registering cloud services with the cloud provider, provisioning each registered cloud service that is requested by the cloud provider, and operating each provisioned service. For the cloud provider, orchestration involves publishing each registered service as available to crowd sourced cloud users, receiving requests for cloud services from a crowd sourced cloud user, and requesting, from a crowd sourced cloud application, a registered service responsive to the request for cloud services.Type: GrantFiled: September 11, 2015Date of Patent: April 24, 2018Assignee: CISCO TECHNOLOGY, INC.Inventors: Plamen Nedeltchev, John Christopher Cottrell
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Patent number: 9654941Abstract: Methods and apparatus for managing interruptions in a multiple communication mode environment are provided herein. For example, a method may include receiving at least first instance of communication data associated with a first communication mode; obtaining first attribute data related to the first instance of communication data; classifying the first instance of communication data into first category based on the first attribute data using the interruption management device; and determining whether to interrupt a user by delivering the first instance of communication data based on the first category. The first category may be selected from a plurality of predetermined categories using a classification algorithm.Type: GrantFiled: December 8, 2014Date of Patent: May 16, 2017Assignee: Cisco Technology, Inc.Inventors: Vikram Kumaran, John Christopher Cottrell
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Publication number: 20160080477Abstract: A first party, such as a residential subscriber to an Internet Service Provider (ISP), logically partitions its computing resources into an end user partition and a crowd sourced cloud partition. The first party installs a crowd sourced cloud application in each cloud partition. Together, a cloud provider computing system and each cloud application orchestrate cloud services over a communications network, such as the Internet. For each crowd sourced cloud application, orchestration involves registering cloud services with the cloud provider, provisioning each registered cloud service that is requested by the cloud provider, and operating each provisioned service. For the cloud provider, orchestration involves publishing each registered service as available to crowd sourced cloud users, receiving requests for cloud services from a crowd sourced cloud user, and requesting, from a crowd sourced cloud application, a registered service responsive to the request for cloud services.Type: ApplicationFiled: September 11, 2015Publication date: March 17, 2016Inventors: Plamen Nedeltchev, John Christopher Cottrell
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Publication number: 20150094032Abstract: Methods and apparatus for managing interruptions in a multiple communication mode environment are provided herein. For example, a method may include receiving at least first instance of communication data associated with a first communication mode; obtaining first attribute data related to the first instance of communication data; classifying the first instance of communication data into first category based on the first attribute data using the interruption management device; and determining whether to interrupt a user by delivering the first instance of communication data based on the first category. The first category may be selected from a plurality of predetermined categories using a classification algorithm.Type: ApplicationFiled: December 8, 2014Publication date: April 2, 2015Inventors: Vikram Kumaran, John Christopher Cottrell
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Patent number: 8923822Abstract: Methods and apparatus for managing interruptions in a multiple communication mode environment are provided herein. For example, a method may include receiving at least first and second instances of communication data associated with first and second communication modes; obtaining first and attribute data related to the first and second instances of communication data; classifying the first and second instances of communication data into first and second categories based on the first and second attribute data using the interruption management device; and determining whether to interrupt a user by delivering the first instance of communication data or the second instance of communication data based on the first and second categories, respectively. The first category and the second category may be selected from a plurality of predetermined categories using a classification algorithm. The first communication mode may be different than the second communication mode.Type: GrantFiled: May 2, 2012Date of Patent: December 30, 2014Assignee: Cisco Technology, Inc.Inventors: Vikram Kumaran, John Christopher Cottrell
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Publication number: 20130295973Abstract: Methods and apparatus for managing interruptions in a multiple communication mode environment are provided herein. For example, a method may include receiving at least first and second instances of communication data associated with first and second communication modes; obtaining first and attribute data related to the first and second instances of communication data; classifying the first and second instances of communication data into first and second categories based on the first and second attribute data using the interruption management device; and determining whether to interrupt a user by delivering the first instance of communication data or the second instance of communication data based on the first and second categories, respectively. The first category and the second category may be selected from a plurality of predetermined categories using a classification algorithm. The first communication mode may be different than the second communication mode.Type: ApplicationFiled: May 2, 2012Publication date: November 7, 2013Applicant: CISCO TECHNOLOGY, INC.Inventors: Vikram Kumaran, John Christopher Cottrell