Patents by Inventor Christopher Cozens

Christopher Cozens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND SYSTEMS FOR PROTEIN ENGINEERING AND PRODUCTION
    Publication number: 20220064634
    Abstract: The present invention provides methods for producing a protein having one or more desired properties, the method comprising: (a) a library design step, (b) a library testing step; and (c) a learning step, in which the sequence variants are each assigned a fitness score based at least in part on the result of the library testing step, and a machine learning algorithm uses the fitness score of each of the sequence variants to train a model to predict the fitness score for new sequence variants, and wherein the machine learning model trained in step (c) is used to design a new library of sequence variants. The present invention also provides a system for producing a protein having one or more desired properties, said system adapted to implement the method of the invention.
    Type: Application
    Filed: May 11, 2020
    Publication date: March 3, 2022
    Applicant: LabGenius Ltd
    Inventors: Harrison Frederick Rickerby, James Edward John Field, Ekaterina Victorovna Putintseva, Christopher Cozens
  • ENZYMES
    Publication number: 20180237756
    Abstract: The invention relates to a nucleic acid polymerase capable of producing a non-DNA nucleotide polymer from a DNA nucleotide template, said polymerase comprising amino acid sequence having at least 36% identity to the amino acid sequence of SEQ ID NO:1, wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at one or more residues of the thumb region, said residues selected from: amino acids 651 to 679 (patch 10A); wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at residue E664. In one embodiment said polymerase comprises the mutations Y409G and E664K. In one embodiment said polymerase comprises amino acid sequence corresponding to SEQ ID NO:12.
    Type: Application
    Filed: March 13, 2018
    Publication date: August 23, 2018
    Applicant: MEDICAL RESEARCH COUNCIL
    Inventors: Philipp Holliger, Christopher Cozens, Vitor B. Pinheiro, Alexander I. Taylor
  • Enzymes
    Patent number: 9938511
    Abstract: The invention relates to a nucleic acid polymerase capable of producing a non-DNA nucleotide polymer from a DNA nucleotide template, said polymerase comprising amino acid sequence having at least 36% identity to the amino acid sequence of SEQ ID NO:1, wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at one or more residues of the thumb region, said residues selected from: amino acids 651 to 679 (patch 10A); wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at residue E664. In one embodiment said polymerase comprises the mutations Y409G and E664K. In one embodiment said polymerase comprises amino acid sequence corresponding to SEQ ID NO:12.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: April 10, 2018
    Assignee: Medical Research Council
    Inventors: Philipp Holliger, Christopher Cozens, Vitor B. Pinheiro, Alexander I. Taylor
  • ENZYMES
    Publication number: 20160097041
    Abstract: The invention relates to a nucleic acid polymerase capable of producing a non-DNA nucleotide polymer from a DNA nucleotide template, said polymerase comprising amino acid sequence having at least 36% identity to the amino acid sequence of SEQ ID NO:1, wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at one or more residues of the thumb region, said residues selected from: amino acids 651 to 679 (patch 10A); wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at residue E664. In one embodiment said polymerase comprises the mutations Y409G and E664K. In one embodiment said polymerase comprises amino acid sequence corresponding to SEQ ID NO:12.
    Type: Application
    Filed: October 1, 2015
    Publication date: April 7, 2016
    Inventors: Philipp Holliger, Christopher Cozens, Vitor B. Pinheiro, Alexander I. Taylor
  • Enzymes
    Patent number: 9169471
    Abstract: The invention relates to a nucleic acid polymerase capable of producing a non-DNA nucleotide polymer from a DNA nucleotide polymer template, said polymerase comprising amino acid sequence having at least 36% identity to the amino acid sequence of SEQ ID NO:1, wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at one or more residues of the thumb region, said residues selected from: amino acids 651 to 679 (patch 10A); wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at residue E664. In one embodiment said polymerase comprises the mutations Y409G and E664K. In one embodiment said polymerase comprises amino acid sequence corresponding to SEQ ID NO:12.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: October 27, 2015
    Assignee: Medical Research Council
    Inventors: Philipp Holliger, Christopher Cozens, Vitor B. Pinheiro, Alexander I. Taylor
  • ENZYMES
    Publication number: 20130130320
    Abstract: The invention relates to a nucleic acid polymerase capable of producing a non-DNA nucleotide polymer from a DNA nucleotide polymer template, said polymerase comprising amino acid sequence having at least 36% identity to the amino acid sequence of SEQ ID NO:1, wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at one or more residues of the thumb region, said residues selected from: amino acids 651 to 679 (patch 10A); wherein said amino acid sequence is mutated relative to the amino acid sequence of SEQ ID NO:1 at residue E664. In one embodiment said polymerase comprises the mutations Y409G and E664K. In one embodiment said polymerase comprises amino acid sequence corresponding to SEQ ID NO:12.
    Type: Application
    Filed: April 14, 2011
    Publication date: May 23, 2013
    Inventors: Philipp Holliger, Christopher Cozens, Vitor B. Pinheiro