Patents by Inventor Christopher Crum

Christopher Crum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND REAGENTS FOR DETECTION AND TREATMENT OF ESOPHAGEAL METAPLASIA
    Publication number: 20140255430
    Abstract: The invention described herein relates to the treatment, detection, and diagnosis of various cancers, including esophageal or gastric adenocarcinoma and related metaplasias. The invention also includes a clonal population of Barrett's esophagus progenitor cells and methods of using them for the treatment, detection, and diagnosis of Barrett's esophagus.
    Type: Application
    Filed: December 20, 2013
    Publication date: September 11, 2014
    Applicants: NATIONAL UNIVERSITY OF SINGAPORE, Agency for Science, Technology and Research (A*Star), Harvard University, Brigham & Women's Hospital, Multiclonal Therapeutics, Inc.
    Inventors: Wa XIAN, Frank MCKEON, Matthew VINCENT, Christopher CRUM, Khek Yu HO
  • H3K27me3 and Cancer
    Publication number: 20120202843
    Abstract: Methods of diagnosing and monitoring cancers and precancerous lesions associated with human papillomavirus (HPV), by detecting abnormal levels of lysine (K)-specific demethylase 6A (KDM6A), KDM6B, or trimethylated Histone H3 Lys27 (H3K27me3).
    Type: Application
    Filed: July 14, 2010
    Publication date: August 9, 2012
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Karl Munger, Christopher Crum, Margaret McLaughlin-Drubin
  • Cell regulatory genes, encoded products, and uses related thereto
    Publication number: 20060019310
    Abstract: Disclosed herein are methods for diagnosing cancer in a biological sample comprising measuring the level of a p63 gene product in the sample.
    Type: Application
    Filed: April 19, 2005
    Publication date: January 26, 2006
    Inventors: Frank McKeon, Annie Yang, Massimo Loda, Sabina Signoretti, Christopher Crum
  • Cell regulatory genes, encoded products, and uses related thereto
    Patent number: 6946256
    Abstract: This application describes the cloning of p63, a gene at chromosome 3q27-29, that bears homology to the tumor suppressor p53. The p63 gene encodes at least six different isotypes. p63 was detected in a variety of human and mouse tissue and demonstrates remarkably divergent activities, such as the ability to transactivate p53 reporter genes and induce apoptosis. Isotopes of p63 lacking a transactivation domain act as dominant negatives towards the transactivation by p53 and p63.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: September 20, 2005
    Assignees: President & Fellows of Harvard College, The Brigham and Women's Hospital, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Frank McKeon, Annie Yang, Massimo Loda, Sabina Signorretti, Christopher Crum