Publication number: 20040197888
Abstract: The present invention features nucleic acids and polypeptides encoding four novel splice variant isoforms of histone deacetylase 3 (HDAC3). The polynucleotide sequences of HDAC3sv1.1, HDAC3sv1.2, HDAC3sv2, HDAC3sv3, HDAC3sv4, HDAC3sv5, and HDAC3sv6 are provided by SEQ ID NO 1, SEQ ID NO 3, SEQ ID NO 5, SEQ ID NO 7, SEQ ID NO 9, SEQ ID NO 20, and SEQ ID NO 21, respectively. The amino acid sequences for HDAC3sv1.1, HDAC3sv1.2, HDAC3sv2, HDAC3sv3, and HDAC3sv4 are provided by SEQ ID NO 2, SEQ ID NO 4, SEQ ID NO 6, SEQ ID NO 8, and SEQ ID NO 10, respectively. The present invention also provides methods for using HDAC3sv1.1, HDAC3sv1.2, HDAC3sv2, HDAC3sv3, and HDAC3sv4 polynucleotides and proteins to screen for compounds that bind to HDAC3sv1.1, HDAC3sv1.2, HDAC3sv2, HDAC3sv3, or HDAC3sv4, respectively.
Type:
Application
Filed:
December 22, 2003
Publication date:
October 7, 2004
Inventors:
Christopher D. Armour, Patrick M. Loerch, John C. Castle, Jason M. Johnson