Abstract: Provided herein according to some embodiments is a method of treating acute neural injury in a subject in need thereof, comprising administering to the subject a compound of Formula I or Formula II. Also provided is a method of treating vascular dementia in a subject in need thereof, comprising administering to the subject a compound of Formula I or Formula II. Further provided is a method of treating CNS lupus in a subject in need thereof, comprising administering to the subject a compound of Formula I or Formula II.

Abstract: Provided herein according to some embodiments is a compound of Formula (I): [Formula], or a pharmaceutically acceptable salt or prodrug thereof. Compositions comprising the compound, and uses thereof for inhibiting the activity of quinone reductase-2, as well as in methods of treatment, are also provided.

Abstract: Described herein are substituted indazoles comprising formula (II) that may selectively bind to Hsp90, methods of using the compounds, and kits including the compounds. Formula (II) may link to detection moieties such as fluorophores that may allow for selective detection of Hsp90 in a sample.

Abstract: Described herein are compounds that may selectively bind to Hsp90, methods of using the compounds, and kits including the compounds. The compounds may include detection moieties such as fluorophores that may allow for selective detection of Hsp90 in a sample.

Abstract: Imaging agents for magnetic resonance imaging are disclosed. Also disclosed are methods of non-invasively generating a visible image of a target tissue. In some embodiments, the discloses methods include the steps of (a) providing a contrast enhancement agent comprising a small molecule that binds to a biomolecule present in the target tissue; (b) introducing the contrast enhancement agent into the target tissue; and (c) scanning the target tissue using magnetic resonance imaging, whereby a visible image of the target tissue is non-invasively generated. Further discloses are methods for monitoring a response to a therapy, methods for selecting a therapy for a subject, methods for delineating a boundary between a diseased cell and a non-diseased cell in a tissue, and methods for assessing the degree to which a target tissue has been removed from a subject.