Patents by Inventor Christopher D. Reeves
Christopher D. Reeves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220127620Abstract: Provide are modified host cells that are engineered to decrese expression of a product to undetectable levels in the presence of an exogenous agent, and increase expression of the product in the presence of another exogenous agent. The modified yeast strainshost cells do not express detectable levels of a precursor or substrate used to make the product. The product can be a cannabinoid or precursor thereof, and the substrate can be hexanoate. Also provided are methods for making a product using the modified host cells. The modified host cell can be a yeast strain, such as S. cerevisiae.Type: ApplicationFiled: March 13, 2020Publication date: April 28, 2022Inventors: Christopher D. REEVES, Christopher J. PADDON, Victor F. HOLMES, Andrew P. KLEIN
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Patent number: 7610316Abstract: Some large software development projects need more than one versioning system to accommodate not only a diversity of document formats and data types, but also the geographic diversity of its programmers. However, having more than one versioning system is generally very expensive. A major factor in this expense is the requirement for a separate application program interface (API) for each separate versioning system. Accordingly, the inventors devised an exemplary API architecture that can be extended with “plug-in”protocol providers to include virtually any number of separate version stores or versioning systems. The exemplary architecture includes a generic command parser and a command dispatcher. The command dispatcher operatively couples to one or more protocol providers, each coupled to at least one version store.Type: GrantFiled: September 7, 2004Date of Patent: October 27, 2009Assignee: Microsoft CorporationInventors: Bradley J. Bartz, Michael R. Santoro, Christopher G. Kaler, Zachary L. Anderson, Christopher D. Reeves
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Patent number: 7332576Abstract: Domains of ambruticin polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare ambruticin in pharmaceutically useful quantities are described, as are methods to prepare ambruticin analogs and other polyketides using the polynucleotides encoding ambruticin synthase domains or modifying enzymes.Type: GrantFiled: March 7, 2005Date of Patent: February 19, 2008Assignee: Kosan Biosciences Inc.Inventors: Christopher D. Reeves, Bryan Julien, Ralph C. Reid
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Patent number: 7285405Abstract: Domains of jerangolid polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare jerangolid in pharmaceutically useful quantities are described, as are methods to prepare jerangolid analogs and other polyketides using the polynucleotides encoding jerangolid synthase domains or modifying enzymes.Type: GrantFiled: April 18, 2005Date of Patent: October 23, 2007Assignee: Kosan Biosciences IncorporatedInventors: Christopher D. Reeves, Ralph C. Reid
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Patent number: 6842904Abstract: Some large software development projects need more than one versioning system to accommodate not only a diversity of document formats and data types, but also the geographic diversity of its programmers. However, having more than one versioning systems is generally very expensive. A major factor in this expense is the requirement for a separate application program interface (API) for each separate versioning system. Accordingly, the inventors devised an exemplary API architecture which can be extended with “plug-in” protocol providers to include virtually any number of separate version stores or versioning systems. The exemplary architecture includes a generic command parser and a command dispatcher. The command dispatcher operatively couples to one or more protocol providers, each coupled to at least one version store.Type: GrantFiled: November 21, 2000Date of Patent: January 11, 2005Assignee: Microsoft CorporationInventors: Bradley J. Bartz, Michael R. Santoro, Christopher G. Kaler, Zachary L. Anderson, Christopher D. Reeves
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Patent number: 6174706Abstract: DNA encoding triol polyketide synthase (TPKS) has been isolated, purified and sequenced. Expression vectors comprising TPKS, cells transformed with the expression vectors, and processes employing the transformed cells are provided.Type: GrantFiled: January 8, 1998Date of Patent: January 16, 2001Assignee: Merck & Co., Inc.Inventors: Victor A. Vinci, Michael J. Conder, Phyllis C. McAda, Christopher D. Reeves, John Rambosek, Charles Ray Davis, Lee E. Hendrickson
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Patent number: 6071713Abstract: A bioprocess for preparing adipoyl-7-ACA comprising the steps: (a) transforming cells of a strain of Penicillium chrysogenum which produces isopenicillin N with an expression vector containing DNA encoding an enzyme, having expandase activity capable of accepting adipoyl 6-APA as a substrate, an enzyme having hydroxylase activity capable of accepting adipoyl-7-ADCA as a substrate and an enzyme having acetyl transferase activity capable of accepting adipoyl 7-ADAC as a substrate; (b) culturing the transformed cells from step a) in a suitable culture medium containing an adipate feedstock, wherein said cells produce adipoyl 6-APA; and (c) culturing the transformed cells producing adipoyl 6-APA of step b) under conditions suitable for expression of said DNA encoding enzyme, thereby producing the end product adipoyl-7-ACA.Type: GrantFiled: June 28, 1999Date of Patent: June 6, 2000Assignee: Gist-Brocades B.V.Inventors: Michael J. Conder, John A. Rambosek, Phyllis C. McAda, Christopher D. Reeves
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Patent number: 6017726Abstract: A process for making 7-aminodeacetyl-cephalosporanic acid (7-ADAC).Type: GrantFiled: April 17, 1997Date of Patent: January 25, 2000Assignee: Gist-Brocades B.V.Inventors: Michael J. Conder, John A. Rambosek, Phyllis C. McAda, Christopher D. Reeves
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Patent number: 5849541Abstract: DNA encoding triol polyketide synthase (TPKS) from Aspergillus terreus has been isolated, purified and sequenced. Expression vectors comprising said DNA, cells transformed with the expression vectors, and processes employing the transformed cells are provided.Type: GrantFiled: August 23, 1996Date of Patent: December 15, 1998Assignee: Merck & Co., Inc.Inventors: Victor A. Vinci, Michael J. Conder, Phyllis C. McAda, Christopher D. Reeves, John Rambosek, Charles Ray Davis, Lee E. Hendrickson
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Patent number: 5744350Abstract: DNA encoding triol polyketide synthase (TPKS) has been isolated, purified and sequenced. Expression vectors comprising TPKS, cells transformed with the expression vectors, and processes employing the transformed cells are provided.Type: GrantFiled: May 25, 1995Date of Patent: April 28, 1998Assignee: Merck & Co., Inc.Inventors: Victor A. Vinci, Michael J. Conder, Phyllis C. McAda, Christopher D. Reeves, John Rambosek, Charles Ray Davis, Lee E. Hendrickson
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Patent number: 5629171Abstract: Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in the presence of an adipate feedstock to produce adipoyl-6-APA (6-amino penicillanic acid); followed by the in situ expression of the following genes with which the P. chrysogenum has been transformed:1) an expandase gene, whose expression product converts the adipoyl-6-APA by ring expansion to adipoyl-7-ADCA;2) an hydroxylase gene whose expression product converts the 3-methyl side chain of adipoyl-7-ADCA to 3-hydroxymethyl, to give the first product, 7-aminodeacetylcephalosporanic acid (7-ADAC); and3) an acetyltransferase gene whose expression product converts the 3-hydroxymethyl side chain to the 3-acetyloxymethyl side chain of 7-ACA. The final product, 7-ACA, is then prepared by cleavage of the adipoyl side chain using an adipoyl acylase.Type: GrantFiled: May 11, 1995Date of Patent: May 13, 1997Assignee: Gist-Brocades B.V.Inventors: Michael J. Conder, John A. Rambosek, Phyllis C. McAda, Christopher D. Reeves
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Patent number: 5559005Abstract: Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in the presence of an adipate feedstock to produce adipoyl-6-APA (6-amino penicillanic acid); followed by the in situ expression of the following genes with which the P. chrysogenum has been transformed:1) an expandase gene, e.g., from Cephalosporium acremonium, whose expression product converts the adipoyl-6-APA by ring expansion to adipoyl-7-ADCA;2) an hydroxylase gene whose expression product converts the 3-methyl side chain of adipoyl-7-ADCA to 3-hydroxymethyl, to give the first product, 7-aminodeacetylcephalosporanic acid (7-ADAC); and3) an acetyltransferase gene whose expression product converts the 3-hydroxymethyl side chain to the 3-acetyloxymethyl side chain of 7-ACA.Type: GrantFiled: May 27, 1994Date of Patent: September 24, 1996Assignee: Merck & Co., Inc.Inventors: Michael J. Conder, Phyllis C. McAda, John A. Rambosek, Christopher D. Reeves