Patents by Inventor Christopher D. Spilling

Christopher D. Spilling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorescent labeled inhibitors
    Patent number: 10047112
    Abstract: Provided herein are a series of fluorescently labeled phosphonate and phosphate compounds such as can be used for affinity probes to detect certain enzymes including lipases. Also provided are methods of making and using such compounds.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: August 14, 2018
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Christopher D. Spilling, Benjamin P. Martin, Stephane Canaan, Jean-Francois Cavalier
  • Fluorescent Labeled Inhibitors
    Publication number: 20170066790
    Abstract: Provided herein are a series of fluorescently labeled phosphonate and phosphate compounds such as can be used for affinity probes to detect certain enzymes including lipases. Also provided are methods of making and using such compounds.
    Type: Application
    Filed: February 23, 2015
    Publication date: March 9, 2017
    Inventors: Christopher D. Spilling, Benjamin P. Martin, Stephane Canaan, Jean-Francois Cavalier
  • Flow-through filter to remove aluminum from medical solutions
    Patent number: 9259670
    Abstract: A flow through filter assembly includes a trivalent and tetravalent metal ion capturing agent and a flow controller providing a predetermined flow rate which allows capture of the trivalent and tetravalent metal ions by the capturing agent.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: February 16, 2016
    Assignees: The University of Kentucky Research Foundation, The Curators of the University of Missouri, Alkymos, Inc.
    Inventors: Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Robert Joseph Kuhn, Vasiliy Paul Abramov, Jason Matthew Lone
  • Chelating compounds and immobilized tethered chelators
    Patent number: 9139456
    Abstract: Novel compounds useful as chelators, intermediates for their production and methods for removing trivalent and tetravalent metal ions from solution are presented.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: September 22, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Robert Joseph Kuhn, Surendra Dawadi
  • FLOW-THROUGH FILTER TO REMOVE ALUMINUM FROM MEDICAL SOLUTIONS
    Publication number: 20140231321
    Abstract: A flow through filter assembly includes a trivalent and tetravalent metal ion capturing agent and a flow controller providing a predetermined flow rate which allows capture of the trivalent and tetravalent metal ions by the capturing agent.
    Type: Application
    Filed: February 21, 2014
    Publication date: August 21, 2014
    Applicants: The Curators of the University of Missouri, The University of Kentucky Research Foundation
    Inventors: Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Robert Joseph Kuhn, Vasiliy Paul Abramov, Jason Matthew Lone
  • CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS
    Publication number: 20120061325
    Abstract: Novel compounds useful as chelators, intermediates for their production and methods for removing trivalent and tetravalent metal ions from solution are presented.
    Type: Application
    Filed: October 21, 2011
    Publication date: March 15, 2012
    Inventors: Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Robert Joseph Kuhn, Surendra Dawadi
  • Removing aluminum from solution using chelating compounds and immobilized tethered chelators
    Patent number: 8066883
    Abstract: Methods are described for removing aluminum from a solution using novel di- and tripodal compounds as chelators.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: November 29, 2011
    Assignee: University of Kentucky Research Foundation
    Inventors: Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Chang-Guo Zhan
  • CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS
    Publication number: 20110168636
    Abstract: Methods are described for removing aluminum from a solution using novel di- and tripodal compounds as chelators.
    Type: Application
    Filed: March 21, 2011
    Publication date: July 14, 2011
    Inventors: Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Chang-Guo Zhan
  • Chelating compounds and immobilized tethered chelators
    Patent number: 7932326
    Abstract: Novel di- and tripodal compounds useful as chelators, intermediates for their production and a method for treating an aqueous solution to remove trivalent metal ions are presented.
    Type: Grant
    Filed: April 16, 2008
    Date of Patent: April 26, 2011
    Assignee: The University of Kentucky Research Foundation
    Inventors: Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Chang-Guo Zhan
  • CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS
    Publication number: 20090261043
    Abstract: Novel di- and tripodal compounds useful as chelators, intermediates for their production and a method for treating an aqueous solution to remove trivalent metal ions are presented.
    Type: Application
    Filed: April 16, 2008
    Publication date: October 22, 2009
    Inventors: Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Chang-Guo Zhan
  • Use of ammonium formate as a hydrogen transfer reagent for reduction of chiral nitro compounds with retention of configuration
    Patent number: 5099067
    Abstract: The present invention relates to a method of converting .beta.-nitro compounds, specifically alcohols, into the corresponding hydroxy amines with retention of configuration by the use of ammonium formate.
    Type: Grant
    Filed: August 15, 1991
    Date of Patent: March 24, 1992
    Assignee: Northwestern University
    Inventors: Anthony G. M. Barrett, Christopher D. Spilling
  • Method of preparing stereospecific nitroaldols
    Patent number: 4933505
    Abstract: A method of controlling the diastereoselectivity of the nitroaldol reaction by the use of titanium, zirconium and aluminum based Lewis acids is disclosed. In a preferred embodiment, the reaction of lithium nitronate anion with aldehydes in THF/CH.sub.2 Cl.sub.2 at reduced temperature in the presence of isopropoxy titanium trichloride (TiCl.sub.3 (OPr.sup.i)) yields nitro alcohols enriched in the erythro diastereomer. Erythro-threo ratios of 11.2:1-3.4:1 for aromatic aldehydes and 3.8:1-1:1 for aliphatic aldehydes are typically obtained.
    Type: Grant
    Filed: August 5, 1988
    Date of Patent: June 12, 1990
    Assignee: Northwestern University
    Inventors: Anthony G. M. Barrett, Christopher D. Spilling