Abstract: Disclosed are methods of treating diseases or disorders associated with cellular senescence as well as methods of inducing ferroptosis in senescent cells. The methods include administering a compound that induces ferroptosis.

Abstract: Methods are provided that relate to the discovery that dihomo-gamma linolenic acid (DGLA) is a potent senolytic agent. Accordingly, in certain embodiments, methods of selectively killing one or more senescent cells in a subject in need thereof are provided wherein the method(s) involves administering to the subject an effective amount of DGLA.

Abstract: Various biological markers that function as indicators of the level of senescent cells in an organism are provided. In certain embodiments, the markers described herein (e.g., eicosanoids) can provide effective indicators of the presence and/or quantity of senescent cells in a subject (e.g., in a human or non-human mammal) and methods of identifying elevated levels of senescent cells in a mammal, and methods for determining the efficacy of senolytic agents, are provided.