Patents by Inventor Christopher D. Zahm

Christopher D. Zahm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-TUMOR DNA VACCINE WITH PD-1 AND LAG-3 PATHWAY BLOCKADE
    Publication number: 20240424074
    Abstract: The present invention provides combination therapies and methods of treating cancer, including, cancers that are resistant to PD-1 therapy. The combination therapies described herein comprise a DNA vaccine to a tumor antigen, anti-PD-1 therapy, and an anti-LAG-3 therapy, which provides an increased T cell response against the cancer.
    Type: Application
    Filed: March 6, 2024
    Publication date: December 26, 2024
    Inventors: Douglas McNeel, Christopher D. Zahm, Jena Moseman
  • TLR AGONISTS FOR REDUCING ACTIVATION-INDUCED PD-1 EXPRESSION ON T CELLS AND METHODS OF USE
    Publication number: 20240390487
    Abstract: The present invention is directed toward methods of increasing the immune response to an antigen using TLR1/2 agonist and/or TLR7 agonist in combination with a T cell activating treatment, for example, a vaccine. In some aspects, the present invention provides methods of enhancing an anti-tumor response comprising administering at least one TLR1/2 agonist and/or at least one TLR7 agonist in combination with an immunotherapeutic agent.
    Type: Application
    Filed: March 12, 2024
    Publication date: November 28, 2024
    Inventors: Douglas G. McNeel, Christopher D. Zahm
  • ANTI-TUMOR DNA VACCINE WITH PD-1 AND LAG-3 PATHWAY BLOCKADE
    Publication number: 20220347282
    Abstract: The present invention provides combination therapies and methods of treating cancer, including, cancers that are resistant to PD-1 therapy. The combination therapies described herein comprise a DNA vaccine to a tumor antigen, anti-PD-1 therapy, and an anti-LAG-3 therapy, which provides an increased T cell response against the cancer.
    Type: Application
    Filed: April 28, 2022
    Publication date: November 3, 2022
    Inventors: Douglas McNeel, Christopher D. Zahm, Jena Moseman
  • IDO ACTIVITY AS A MARKER OF TUMOR IMMUNE ESCAPE AND IDO INHIBITORS AS A MEANS OF ENHANCING T CELLS RESPONSE TO ANTIGEN SPECIFIC VACCINE
    Publication number: 20220218809
    Abstract: The present invention provides compositions and methods of treating prostate cancer using a combination of a DNA vaccine, PD-1 inhibitor and an IDO inhibitor. Further, methods of measuring IDO activity as a way to identify a subpopulation of subjects with prostate cancer that may benefits from the treatment methods described herein are provided.
    Type: Application
    Filed: November 6, 2019
    Publication date: July 14, 2022
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Douglas G. McNeel, Christopher D. Zahm, Laura Johnson
  • TLR AGONISTS FOR REDUCING ACTIVATION-INDUCED PD-1 EXPRESSION ON T CELLS AND METHODS OF USE
    Publication number: 20180169224
    Abstract: The present invention is directed toward methods of increasing the immune response to an antigen using TLR1/2 agonist and/or TLR7 agonist in combination with a T cell activating treatment, for example, a vaccine. In some aspects, the present invention provides methods of enhancing an anti-tumor response comprising administering at least one TLR1/2 agonist and/or at least one TLR7 agonist in combination with an immunotherapeutic agent.
    Type: Application
    Filed: December 12, 2017
    Publication date: June 21, 2018
    Inventors: Douglas G. McNeel, Christopher D. Zahm
  • PI3-Kinase Inhibition and LAG-3 Checkpoint blockade as a Combination Therapy for Cancer
    Publication number: 20180043011
    Abstract: This disclosure provides methods of treating cancer comprising administering at least one PI3K inhibitor and at least one LAG-3 checkpoint inhibitor. Suitable compositions are also disclosed.
    Type: Application
    Filed: August 10, 2017
    Publication date: February 15, 2018
    Inventors: Douglas G. McNeel, Viswa T. Colluru, Christopher D. Zahm