Abstract: The present invention provides antibodies that bind to ErbB3 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human ErbB3. In certain embodiments, the antibodies of the present invention block the interaction of ErbB3 with an ErbB3 ligand such as neuregulin 1. The antibodies of the invention are useful for the treatment of various cancers.

Abstract: The present invention provides methods for treating or preventing malaria by administering to a patient in need thereof a pharmaceutical composition comprising an antibody that specifically binds human angiopoietin-2 (Ang-2).

Abstract: The present invention provides pharmaceutical compositions comprising an anti-ErbB3 antibody and an anti-EGFR antibody, and methods of use thereof. The compositions and methods of the present invention are useful for the treatment of various cancers and other diseases and disorders.

Abstract: The present invention provides antibodies that bind to EGFR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human EGFR with high affinity. In certain embodiments, the antibodies of the present invention are capable of inhibiting the growth of tumor cells expressing high levels of EGFR and/or inducing antibody-dependent cell-mediated cytotoxicity (ADCC) of such cells. The antibodies of the invention are useful for the treatment of various cancers as well as other EGFR-related disorders.

Abstract: A system for facilitating settlement of payments relating to transactions involving financial instruments among multiple participants is provided. An interface receives from participants first and second instructions associated with a financial instrument of a first form, and first and second instructions associated with a financial instrument of a second form. A first processor establishes an association between, and applies a first set of pre-settlement rules to, the first and second instructions associated with the financial instrument of the first form. A second processor establishes an association between, and applies a second set of pre-settlement rules to, the first and second instructions associated with the financial instrument of the second form.

Abstract: A system for facilitating settlement of payments relating to transactions involving financial instruments among multiple participants is provided. An interface receives from participants first and second instructions associated with a financial instrument of a first form, and first and second instructions associated with a financial instrument of a second form. A first processor establishes an association between, and applies a first set of pre-settlement rules to, the first and second instructions associated with the financial instrument of the first form. A second processor establishes an association between, and applies a second set of pre-settlement rules to, the first and second instructions associated with the financial instrument of the second form.

Abstract: The present invention provides methods for treating or preventing malaria by administering to a patient in need thereof a pharmaceutical composition comprising an antibody that specifically binds human angiopoietin-2 (Ang-2).

Abstract: The present invention provides antibodies that bind to angiopoietin-2 (Ang-2) and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human Ang-2. The antibodies of the invention are useful, inter alia, for the treatment of diseases and disorders associated with one or more Ang-2 biological activities including angiogenesis.

Abstract: An implantable component (30) of a cochlear implant system comprising a housing for a stimulator unit (31) that is adapted to output one or more stimulation signals and an electrode assembly (30) adapted to apply electrical stimulation in accordance with the output of the stimulator unit (31). On implantation, the housing is positionable such that the electrode assembly (20) extends from the housing at least initially in a downward orientation toward the mastoid cavity before entering the cochlea. An external component (50, 60 or 70) of a cochlear implant system comprising a support for mounting to the ear of an recipient and an external signal transmitter coil (53) wherein the signal transmitter coil (53) is movably mounted to at least a portion of the support.

Abstract: A system for facilitating settlement of payments relating to transactions involving financial instruments among multiple participants is provided. An interface receives from participants first and second instructions associated with a financial instrument of a first form, and first and second instructions associated with a financial instrument of a second form. A first processor establishes an association between, and applies a first set of pre-settlement rules to, the first and second instructions associated with the financial instrument of the first form. A second processor establishes an association between, and applies a second set of pre-settlement rules to, the first and second instructions associated with the financial instrument of the second form.

Abstract: In accordance with one aspect of the invention, methods and systems are disclosed for delivering a stimulating signal by a stimulating medical device having a plurality of electrodes. Such methods and systems comprise receiving a signal; filtering the received signal to obtain a plurality of band pass filtered signals; delivering to each electrode of a first group of one or more electrodes, a first set of stimulation signals, wherein the first set of stimulation signals comprises stimulations signals for each of a first group of two or more band pass filtered signals; and delivering to each of electrodes of a second group of one or more electrodes, a second set of stimulation signals, wherein the second set of stimulation signals comprises stimulations signals for each of a second group of one or more band pass filtered signals; and wherein the first set of stimulation signals are delivered at a different effective stimulation rate than the second set of stimulation signals.

Abstract: Systems and methods are provided for processing instructions relating respectively to different forms of financial instruments. In one example, a system comprises an interface configured to receive instructions relating to at least two different forms of financial instruments. The system also comprises a plurality of processors each configured to apply a respective set of pre-settlement rules to instructions relating to financial instruments of a respective form.

Abstract: In accordance with one aspect of the invention, methods and systems are disclosed for delivering a stimulating signal by a stimulating medical device having a plurality of electrodes. Such methods and systems comprise receiving a signal; filtering the received signal to obtain a plurality of band pass filtered signals; delivering to each electrode of a first group of one or more electrodes, a first set of stimulation signals, wherein the first set of stimulation signals comprises stimulations signals for each of a first group of two or more band pass filtered signals; and delivering to each of electrodes of a second group of one or more electrodes, a second set of stimulation signals, wherein the second set of stimulation signals comprises stimulations signals for each of a second group of one or more band pass filtered signals; and wherein the first set of stimulation signals are delivered at a different effective stimulation rate than the second set of stimulation signals.

Abstract: The invention provides a method of electrical artefact compensation in measurement of a neural response. The neural response is evoked by a first stimulus, after which a compensatory stimulus is applied in order to counteract a stimulus artefact caused by the first stimulus. The invention also provides for short circuiting the stimulating electrode subsequent to the first stimulus. A system for implementing such steps is also provided. The invention may be of application in measurement of physiological responses, including neural responses and in particular a neural response of the auditory nerve.

Abstract: A method, apparatus and program storage device for representing software models in textual form. A representation of a computer program selected from a group comprising a model and source code representing a model is provided. A counterpart to the selected representation of the computer program is produced.

Abstract: In accordance with one aspect of the invention, methods and systems are disclosed for delivering a stimulating signal by a stimulating medical device having a plurality of electrodes. Such methods and systems comprise receiving a signal; filtering the received signal to obtain a plurality of band pass filtered signals; delivering to each electrode of a first group of one or more electrodes, a first set of stimulation signals, wherein the first set of stimulation signals comprises stimulations signals for each of a first group of two or more band pass filtered signals; and delivering to each of electrodes of a second group of one or more electrodes, a second set of stimulation signals, wherein the second set of stimulation signals comprises stimulations signals for each of a second group of one or more band pass filtered signals; and wherein the first set of stimulation signals are delivered at a different effective stimulation rate than the second set of stimulation signals.

Abstract: In accordance with one aspect of the invention, methods and systems are disclosed for delivering a stimulating signal by a stimulating medical device having a plurality of electrodes. These methods and systems comprise electrically coupling a first set of at least two of the plurality of electrodes, and simultaneously delivering to the first set of electrically-coupled electrodes a stimulation signal suitable for application to a target tissue of a recipient.

Abstract: An implantable component (30) of a cochlear implant system comprising a housing for a stimulator unit (31) that is adapted to output one or more stimulation signals and an electrode assembly (30) adapted to apply electrical stimulation in accordance with the output of the stimulator unit (31). On implantation, the housing is positionable such that the electrode assembly (20) extends from the housing at least initially in a downward orientation toward the mastoid cavity before entering the cochlea. An external component (50, 60 or 70) of a cochlear implant system comprising a support for mounting to the ear of an recipient and an external signal transmitter coil (53) wherein the signal transmitter coil (53) is movably mounted to at least a portion of the support.

Abstract: The invention provides a method of electrical artefact compensation in measurement of a neural response. The neural response is evoked by a first stimulus, after which a compensatory stimulus is applied in order to counteract a stimulus artefact caused by the first stimulus. The invention also provides for short circuiting the stimulating electrode subsequent to the first stimulus. A system for implementing such steps is also provided. The invention may be of application in measurement of physiological responses, including neural responses and in particular a neural response of the auditory nerve.

Abstract: An implanted device such as a cochlear implant system includes a housing containing stimulating pulse generating circuitry, and a plurality of electrodes external of the housing and receiving the pulses. Between the pulses, parasitic voltages may build up between the electrodes. In order to control the inrush current due to these parasitic voltages, multi-position switches are provided which selectively couple the electrodes to resistors selected to dissipate the voltages at a preselected maximum current to protect the body organs.