Abstract: A liner (100) and closure (106) are provided for being initially assembled and subsequently installed on a container (104) of a product to create a package (107, 107A). The liner (100) is provided for being disposed between, and sealed to, the container (104) and the closure (106) mounted thereon. The liner (100) includes a metallic substrate layer (200) that is an aluminum alloy and that is located between first and second heat-sealable layers (212, 200), respectively. The liner (100) has a through hole (252), and the metallic substrate layer (200) has a laterally inward edge surface (210) that is exposed at the through hole (252).

Abstract: A liner (100) and closure (106) are provided for being initially assembled and subsequently installed on a container (104) of a product to create a package (107, 107A). The liner (100) is provided for being disposed between, and sealed to, the container (104) and the closure (106) mounted thereon. The liner (100) includes a metallic substrate layer (200) that is an aluminum alloy and that is located between first and second heat-sealable layers (212, 200), respectively. The liner (100) has a through hole (252), and the metallic substrate layer (200) has a laterally inward edge surface (210) that is exposed at the through hole (252).

Abstract: A closure (20) is provided to selectively permit or restrict communication between the exterior and the interior of a system that has an opening between the exterior and interior. The closure (20) includes a closure body (24) that defines an access passage (30) and a membrane (60) that initially occludes the access passage (30). The connection of the membrane (60) to the body (24) is defined by a tearable portion (68) of material that defines a tear path along which the material can be torn. The tear path has; (A) a first separation path (80) where separation of the membrane (60) from the body (24) initially originates; and (B) a second separation path (90) where separation of the membrane (60) from the body (24) terminates. The second separation path (90) has a generally tapered configuration.

Abstract: A closure (20) is provided to selectively permit or restrict communication between the exterior and the interior of a system that has an opening between the exterior and interior. The closure (20) includes a closure body (24) that defines an access passage (30) and a membrane (60) that initially occludes the access passage (30). The connection of the membrane (60) to the body (24) is defined by a tearable portion (68) of material that defines a tear path along which the material can be torn. The tear path has; (A) a first separation path (80) where separation of the membrane (60) from the body (24) initially originates; and (B) a second separation path (90) where separation of the membrane (60) from the body (24) terminates. The second separation path (90) has a generally tapered configuration.

Abstract: A method for separating nucleic acid from a liquid sample, said method comprising the steps of causing a liquid sample containing or suspected of containing said nucleic acid to flow along a bibulous membrane, for example of a conventional lateral flow device, so that nucleic acid is distributed along the length of the membrane. The nucleic acid may be detected on the membrane.

Abstract: A method for the determination of a target analyte in a sample, said method comprising: a) applying a liquid sample suspected of containing said target analyte to a solid support capable of allowing lateral flow of liquid there through, which support has diffusibly arranged thereon, (i) either (a) a labeled binding partner for said analyte or (b) a labeled analogue of said analyte, and (ii) a labeled control reagent; b) allowing the sample, labeled binding partner for said analyte or a labeled analogue of said analyte and labeled control reagent to flow through a detection zone on said solid support; c) allowing the sample, labeled binding partner for said analyte or a labeled analogue of said analyte and labeled control reagent to flow through a control zone; and d) detecting the labeled density in the detection zone and the label density in the control zone and comparing these densities.

Abstract: A method for separating nucleic acid from a liquid sample, said method comprising the steps of causing a liquid sample containing or suspected of containing said nucleic acid to flow along a bibulous membrane, for example of a conventional lateral flow device, so that nucleic acid is distributed along the length of the membrane. The nucleic acid may be detected on the membrane.

Abstract: A method for the determination of a target analyte in a sample, said method comprising: a) applying a liquid sample suspected of containing said target analyte to a solid support capable of allowing lateral flow of liquid therethrough, which support has diffusibly arranged thereon, (i) either (a) a labelled binding partner for said analyte or (b) a labelled analogue of said analyte, and (ii) a labelled control reagent; b) allowing the sample, labelled binding partner for said analyte or a labelled analogue of said analyte and labelled control reagent to flow through a detection zone on said solid support, wherein in the case of (i) (a) above, a predetermined amount of an analogue of the target analyte is immobilised, or, in the case of (i) (b) above a predetermined amount of a binding partner for said analyte or, labelled analogue is immobilised; c) allowing the sample, labelled binding partner for said analyte or a labelled analogue of said analyte and labelled control reagent to flow through a control zone

Abstract: A closure system is provided with a peripheral wall for extending from a container. A lid is molded with the peripheral wall as a unitary structure connected by a linear array of spaced-apart floppy hinge segments.

Abstract: A process is provided for minimizing moisture accumulation in a product package that is sprayed with a cool water shower. The product is placed in a container, and a closure is installed on a container. The product is heated before it is placed the container or during its placement in the container, or after it is placed in the container, or while the closure is being installed on the container, or after the closure has been installed on the container. The internal atmosphere within the closed closure is allowed to expand from the heat and to vent through a vent channel. The package is cooled with a cooling water shower, and the vent channel minimizes the transient pressure differential so as to minimize the amount of water in filtration into the closure.

Abstract: A dispensing closure system is provided with two or more dispensing apertures and two or more pivotable lids. Each lid can be selectively opened and retained in a fully opened orientation. In a preferred form of the invention, the lids are incorporated in a top that is snap-fitted into a closure body which defines the dispensing apertures.