Abstract: Described herein is the FLAP inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, or a pharmaceutically acceptable salt thereof. Also described are methods of preparing the FLAP inhibitor, or a pharmaceutically acceptable salt thereof, including solvates, and polymorphs thereof. Also described herein are pharmaceutical compositions suitable for administration to a mammal that include the FLAP inhibitor, or a pharmaceutically acceptable salt thereof, and methods of using such pharmaceutical compositions for treating respiratory conditions or diseases, as well as other leukotriene-dependent or leukotriene mediated conditions or diseases.

Abstract: A method of manufacturing a bag from a polymer film is disclosed. The method comprises (a) forming a bag with a front wall, a back wall, a bottom wall, opposed sides defined by heat seals of the front and back walls, skirts extending outwardly from the heat seals and an opening allowing access to the interior of the bag, and (b) piercing the bag and forming micro-perforations to achieve MAP functionality using piercing methods that are selected to reduce the stiction of the film in the front and back walls significantly below the tear strength of the film in the film orientation direction.