Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to treatments of hereditary angioedema (HAE). In particular, the present invention provides on-demand treatments of hereditary angioedema (HAE) by orally administering a plasma kallikrein inhibitor to a patient in need thereof on-demand.

Abstract: A method for producing an olefin product, including the steps of converting a hydrocarbon feedstock to an unsaturated hydrocarbon stream through a steam cracking process in an olefins production plant; combusting hydrogen to provide at least some of the heating duty to the steam cracking process, wherein the hydrogen has a carbon intensity less than about 1.0 kg CO2e/kg H2, wherein the hydrogen is produced using a hydrogen production process; providing at least some of the required energy for the hydrogen production process from a biomass power plant; and processing the unsaturated hydrocarbon stream to recover the olefin product. The olefin product may comprise ethylene having a well-to-gate carbon intensity less than about 0.6 kg CO2e/kg C2H4, or may comprise propylene having a well-to-gate carbon intensity less than about 0.6 kg CO2e/kg C3H6.

Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: Software systems and methods convert algorithms and software codes into time affecting linear pathways (TALPs) via decomposition and convert paired Input/Output (I/O) datasets into TALPs via Value Complexity polynomials. Generated TALPs can be enhanced through merging with other TALPs. TALPs can be grouped by matching the outputs of the TALP-associated prediction polynomials with some set of given criteria into families and cross-families that are useful in a new type of software optimization that allows for output values of grouped TALPs to be modeled, pooled, discretized and optimized to enhance goals or meet user goals.

Abstract: A user equipment (UE) is disclosed comprising an agent configured to monitor and report UE configuration and capability information, wherein the UE is further configured to provide the UE configuration and capability information, and subsequently receive an application based on the configuration and capability information. Also disclosed is a network comprising a provisioning server configured to receive UE configuration and capability information, and subsequently provide an application based on the UE configuration and capability information. Also disclosed is a method comprising providing UE configuration and capability information from a UE, and receiving an application at the UE based on the configuration and capability information. Also disclosed is a method comprising receiving UE configuration and capability information at a provisioning server, and providing an application from the provisioning server based on the UE configuration and capability information.

Abstract: A device-based network service provisioning model is provided in which a wireless device facilitates a subscriber to provide provisioning information for activating carrier, value-added or other service provider services automatically. The model facilitates subscriber control while balancing service provider needs. Provisioning components may be provided to a device during a provisioning session to maintain service provider branding, look and feel and other control over a subscriber's experience. Provisioning components may be dynamically generated to capture current services, subscriber plans and particular device criteria. In one embodiment, service provider-side components define a service-oriented interface (e.g. Web services) for receiving a subscriber's provisioning information. Device-side components define an interface to request and receive the provisioning components and to provide provisioning information to the service-oriented interface.

Abstract: Systems and methods are provided for triggering a provisioning event in a service provider using a provisioning request message generated by an external system. A provisioning system may be used to receive the provisioning request message from the external system and transmit information in the provisioning request message to the service provider to trigger the provisioning event. The provisioning request message may have a data structure that includes a header section and a body section. The body section may contain a provisioning entity section that includes information identifying an entity to which the provisioning event pertains, wherein the provisioning entity section includes one or more attributes defined by the external system.

Abstract: A method for automated selection of a user account is provided. The method includes analyzing a plurality of parameters associated with operation of plurality of user accounts on a mobile device and selecting a user account based on the analysis.

Abstract: A user equipment (UE) is disclosed comprising an agent configured to monitor and report UE configuration and capability information, wherein the UE is further configured to provide the UE configuration and capability information, and subsequently receive an application based on the configuration and capability information. Also disclosed is a network comprising a provisioning server configured to receive UE configuration and capability information, and subsequently provide an application based on the UE configuration and capability information. Also disclosed is a method comprising providing UE configuration and capability information from a UE, and receiving an application at the UE based on the configuration and capability information. Also disclosed is a method comprising receiving UE configuration and capability information at a provisioning server, and providing an application from the provisioning server based on the UE configuration and capability information.

Abstract: Provided are methods and apparatus for managing software components on a device when transferring device management responsibilities for the device from a first device management server to a second device management server. The capability to change device management servers while coordinating changes to software components on a managed device may be referred to as application portability. A mobile device in the present disclosure may change device management providers while maintaining access to certain licensed applications managed by a device management server. In an embodiment, a proprietary software component may be removed and a replacement software component installed from a category of applications that comprises the removed proprietary software component and the installed replacement software component.

Abstract: A device-based network service provisioning model is provided in which a wireless device facilitates a subscriber to provide provisioning information for activating carrier, value-added or other service provider services automatically. The model facilitates subscriber control while balancing service provider needs. Provisioning components may be provided to a device during a provisioning session to maintain service provider branding, look and feel and other control over a subscriber's experience. Provisioning components may be dynamically generated to capture current services, subscriber plans and particular device criteria. In one embodiment, service provider-side components define a service-oriented interface (e.g. Web services) for receiving a subscriber's provisioning information. Device-side components define an interface to request and receive the provisioning components and to provide provisioning information to the service-oriented interface.