Abstract: One aspect of the present disclosure relates to a device for detecting a pathogen biomarker in a biological sample. The device can comprise a substrate. The substrate can comprise paper. The device can also comprise a hydrophobic material applied to the substrate to define at least one target region, a sample region, and at least one channel in fluid communication with the at least one target region and the sample region. The device can further include a predetermined amount of antibodies that specifically bind to at least one pathogen biomarker provided in the at least one target region. The predetermined amount of antibodies is conjugated with colloidal gold.

Abstract: One aspect of the present disclosure relates to a device for detecting a pathogen biomarker in a biological sample. The device can comprise a substrate. The substrate can comprise paper. The device can also comprise a hydrophobic material applied to the substrate to define at least one target region, a sample region, and at least one channel in fluid communication with the at least one target region and the sample region. The device can further include a predetermined amount of antibodies that specifically bind to at least one pathogen biomarker provided in the at least one target region. The predetermined amount of antibodies is conjugated with colloidal gold.

Abstract: The present invention provides compositions and methods for targeting an antigen to leukocytes, delivering an antigen to leukocytes, increasing antigen uptake by leukocytes, and/or enhancing an immune response. In some embodiments, compositions and methods of the present invention comprise a conjugate comprising an antigen and a plant lectin or a mimetic thereof.

Abstract: An exercise machine includes an anchorage adapted to fit on the upper edge of a room door, a lower anchorage adapted to fit on the lower edge of the door, and an operating mechanism trained between the two anchorages. The mechanism includes an elastic resistance device and a variable length connector between the resistance device and a variable length connector between the resistance device and one of the anchorages. A flexible tension element extends around a pulley system within the variable length connector and out of the connector to an external handgrip. The handgrip can be pulled to stress the elastic resistance device.