Abstract: Provided herein is a gene therapy for GLUT1 Deficiency Syndrome and related disorders using a recombinant adeno-associated virus (rAAV) virion as a vector to express an GLUT1 protein or functional variant thereof. The capsid may be an AAV-BR1 capsid or a functional variant thereof. Other promoters or capsids may be used. The rAAV virion may use an endothelial-specific promoter, e.g., a FLT-1 promoter. Further provided are methods of treatment, such as by intracerebrally and/or intravenously of the rAAV virion, and other compositions and methods.

Abstract: The present invention is directed to a device, system and method of attaching an electronic device to a belt, and to a belt having an attached electronic device, that will sit away from the user's body when in use and will be held close to the user's body when not in use. The various embodiments of the present invention also enable the easy transition of the electronic device from the in-use position to the stored position and vice versa. One embodiment of the present invention utilizes two belt clips and a gooseneck electronic device holder to achieve these goals.

Abstract: Provided herein is a gene therapy for PKP2 (Plakophilin-2), e.g. using an adeno-associated virus (AAV) vector. The promoter of the vector may be a MHCK7 promoter or a cardiac troponin T (HTNNT2) promoter. The capsid may be an AAV9 or AAVrh74 capsid or a functional variant thereof. Other promoters or capsids may be used. Further provided are methods of treatment, such as by intravenous, intracoronary, intracarotid or intracardiac administration of the rAAV vector, and other compositions and methods.

Abstract: The intelligent automated assistant system engages with the user in an integrated, conversational manner using natural language dialog, and invokes external services when appropriate to obtain information or perform various actions. The system can be implemented using any of a number of different platforms, such as the web, email, smartphone, and the like, or any combination thereof. In one embodiment, the system is based on sets of interrelated domains and tasks, and employs additional functionally powered by external services with which the system can interact.

Abstract: Provided herein is a gene therapy for PKP2 (Plakophilin-2), e.g. using an adeno-associated virus (AAV) vector. The promoter of the vector may be a MHCK7 promoter or a cardiac troponin T (HTNNT2) promoter. The capsid may be an AAV9 or AAVrh74 capsid or a functional variant thereof. Other promoters or capsids may be used. Further provided are methods of treatment, such as by intravenous, intracoronary, intracarotid or intracardiac administration of the rAAV vector, and other compositions and methods.

Abstract: RFID tag ICs may be configured with privacy modes. When a tag IC is in a privacy mode, it will not respond to commands unless a previous command includes correct verification information or specifies a recycling indicator of the tag IC. If the previous command includes correct verification information, then the tag IC will respond to one or more subsequent commands as normal, for example by responding with one or more identifiers. If the previous command does not include correct verification information but specifies a recycling indicator and the privacy mode is recycling-enabled, the tag IC may respond to one or more subsequent commands with recycling information. The recycling information identifies whether or how an item associated with the RFID IC can be recycled or disposed but does not otherwise identify the RFID IC or item. Otherwise, the tag IC may remain silent.

Abstract: Provided herein is a gene therapy for JPH2 (Junctophilin-2), e.g., using an adeno-associated virus (AAV) vector. The promoter of the vector may be a MHCK7 promoter or a cardiac troponin T (HTNNT2) promoter. The capsid may be an AAV9 or AAVrh74 capsid or a functional variant thereof. Other promoters or capsids may be used. Further provided are methods of treatment, such as by intravenous, intracoronary, intracarotid or intracardiac administration of the rAAV vector, and other compositions and methods.

Abstract: Provided herein is a gene therapy for TNNC1 (Troponin C)-related cardiomyopathy, e.g. using an adeno-associated virus (AAV) vector. The promoter of the vector may be a MHCK7 promoter or a cardiac troponin T (hTNNT2) promoter. The capsid may be an AAV9 or AAVrh.74 capsid or a functional variant thereof. Other promoters or capsids may be used. Further provided are methods of treatment, such as by intravenous, intracoronary, intracarotid or intracardiac administration of the rAAV vector, and other compositions and methods.

Abstract: A fuel cell electric power system includes a fuel cell stack, and a charge air system including an intake air compressor, an exhaust turbine, and a flow control valve assembly. The flow control valve assembly includes at least one flow control valve rotatable in a valve housing to fluidly connect an exhaust inlet, selectively, to a turbine feed outlet via a variable flow area to adjust a torque applied to the exhaust turbine by a flow of exhaust.

Abstract: In some embodiments an apparatus for providing access for a medical procedure in a patient's body cavity includes a stem configured for insertion through an opening in a body cavity wall. The stem has a bore and a cap is disposed at a proximal end thereof and includes an entry port in communication with the bore which receives an instrument to be inserted into the body cavity. An inflatable annular seal is disposed on the stem proximate the cap and a conduit extends through the cap providing pressurized gas at a first outlet in fluid communication with the body cavity providing insufflation pressure. A second outlet of the conduit is in fluid communication the seal, which when disposed inside the body cavity proximate the wall and inflated by pressurized gas, bears on an inner surface of the wall urging the cap into contact with an outer surface of the wall while sealing the opening.

Abstract: A sanitation storage device and a method of installing the same is provided. The device comprises an upper storage portion comprising a platform, an upper storage portion containment feature, and an upper storage portion access opening. The device further comprises a lower storage comprising a lower storage portion access opening and a lower storage portion containment feature. The upper storage portion is configured to receive a first container filled with a hand sanitizer, such that the first container is disposed upon the platform and extends through the upper opening, and the lower storage portion is configured to receive a second container, filled with a cleaning solution, such that the second container is disposed within the interior void. The storage device allows for storage of hand sanitizer and cleaning solution in a manner that conceals the cleaning solution while allowing easy access to the hand sanitizer in the respective communal space.

Abstract: RFID tag ICs may be configured with privacy modes. When a tag IC is in a privacy mode, it will not respond to commands unless a previous command includes correct verification information or specifies a recycling indicator of the tag IC. If the previous command includes correct verification information, then the tag IC will respond to one or more subsequent commands as normal, for example by responding with one or more identifiers. If the previous command does not include correct verification information but specifies a recycling indicator and the privacy mode is recycling-enabled, the tag IC may respond to one or more subsequent commands with recycling information. The recycling information identifies whether or how an item associated with the RFID IC can be recycled or disposed but does not otherwise identify the RFID IC or item. Otherwise, the tag IC may remain silent.

Abstract: A tubing component, and methods of forming, for a particulate material delivery assembly including a particulate delivery device to deliver a mixed particulate solution to a patient. The tubing component includes a material including a material density, and a determined thickness sufficient to shield a delivery line connector of a particulate delivery device from at least 90% of a radiation dose. The delivery line connector is configured to receive the mixed particulate solution from the particulate delivery device of the particulate material delivery assembly, and the determined thickness of the tubing component is calculated based on the material density to achieve shielding of the delivery line connector by the material of at least 90% of the radiation dose. The tubing component includes an integral wall of the delivery line connector, an outer sleeve configured to be removably disposed about the delivery line connector, or combinations thereof.

Abstract: A system, method and/or computer program product may include, a computer-implemented method of altering animated behavior of a character avatar or artificial character including: electronically establishing, by an electronic computer processor, at least one electronic data indicative of at least one parametric mathematical model configured to alter at least one kinetic property of the animated behavior of the character avatar or artificial character, in a manner that creates apparent changes of one or more of: mood, or personality, in the character avatar or artificial character being animated; electronically inserting, an animation representative of the at least one electronic data indicative of the at least one parametric mathematical model, wherein the animation representative of the at least one electronic data indicative of the at least one parametric mathematical model is inserted between timing: of displaying of animated behaviors of the character avatar or artificial character controlling the characte

Abstract: The disclosure generally describes computer-implemented methods, software, and systems for generating a health recommendation. A computer-implemented method includes receiving genetic data and user data of a user. The genetic data is processed to generate vector representations of a fixed size by using an unsupervised learning algorithm. Health risk features are extracted from the vector representations by using a multi-layer convolutional neural network. Dietary conditions associated with the health risk features are determined and used to generate the health recommendation. The health recommendation is displayed for the user.

Abstract: Property Tour Management Systems (PTMS) of the present disclosure may include a PTMS application running on a network that includes multiple mobile digital devices and one or more servers. Each of the mobile digital devices may be used by respective agents or prospective buyers to carry out one or more procedures associated with property tours.

Abstract: Provided herein is a gene therapy for PKP2 (Plakophilin-2), e.g. using an adeno-associated virus (AAV) vector. The promoter of the vector may be a MHCK7 promoter or a cardiac troponin T (HTNNT2) promoter. The capsid may be an AAV9 or AAVrh74 capsid or a functional variant thereof. Other promoters or capsids may be used. Further provided are methods of treatment, such as by intravenous, intracoronary, intracarotid or intracardiac administration of the rAAV vector, and other compositions and methods.

Abstract: The digital assistant displays a digital assistant object in an object region of a display screen. The digital assistant then obtains at least one information item based on a speech input from a user. Upon determining that the at least one information item can be displayed in its entirety in the display region of the display screen, the digital assistant displays the at least one information item in the display region, where the display region and the object region are not visually distinguishable from one another. Upon determining that the at least one information item cannot be displayed in its entirety in the display region of the video display screen, the digital assistant displays a portion of the at least one information item in the display region, where the display region and the object region are visually distinguishable from one another.