Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).

Abstract: A method and a computer readable medium comprising instructions for upgrading a firmware of a peripheral device connected to a host device via a Peripheral Component Interconnect Express (PCIe) bus from the operating system (OS) of the host device is disclosed. In one embodiment, the method and computer readable medium instructions includes halting host device access to the peripheral device after detecting the peripheral device has completed a shutdown sequence, and resetting the peripheral device after a predetermined time period after completion of the shutdown sequence. The method and computer readable medium instructions further includes initializing the firmware stored in a persistent storage location of the peripheral device, and re-establishing a connection between the peripheral device and the host device. In one embodiment, the predetermined time period is greater than a time it takes for the host device to detect the peripheral device has completed the shutdown sequence.

Abstract: The production of bioceramic powders and bioceramic implants are described and an additive manufactured implant used for tissue reconstruction and a method for manufacturing the implant are disclosed. The implant may be fabricated at least in part from suitable bioceramic powders produced using tailored mineral compositions tailored to the unique material properties of the tissue being replaced. The implants may be tailored to a three-dimensional shape and mechanical properties of the tissue defect designed to be replaced by surgical implantation of the device. Native tissue repair and regeneration at the site of implantation are also provided.

Abstract: A method and a computer readable medium comprising instructions for upgrading a firmware of a peripheral device connected to a host device via a Peripheral Component Interconnect Express (PCIe) bus from the operating system (OS) of the host device is disclosed. In one embodiment, the method and computer readable medium instructions includes halting host device access to the peripheral device after detecting the peripheral device has completed a shutdown sequence, and resetting the peripheral device after a predetermined time period after completion of the shutdown sequence. The method and computer readable medium instructions further includes initializing the firmware stored in a persistent storage location of the peripheral device, and re-establishing a connection between the peripheral device and the host device. In one embodiment, the predetermined time period is greater than a time it takes for the host device to detect the peripheral device has completed the shutdown sequence.

Abstract: A method and a computer readable medium comprising instructions for upgrading a firmware of a peripheral device connected to a host device via a Peripheral Component Interconnect Express (PCIe) bus from the operating system (OS) of the host device is disclosed. In one embodiment, the method and computer readable medium instructions includes halting host device access to the peripheral device after detecting the peripheral device has completed a shutdown sequence, and resetting the peripheral device after a predetermined time period after completion of the shutdown sequence. The method and computer readable medium instructions further includes initializing the firmware stored in a persistent storage location of the peripheral device, and re-establishing a connection between the peripheral device and the host device. In one embodiment, the predetermined time period is greater than a time it takes for the host device to detect the peripheral device has completed the shutdown sequence.

Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).

Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high pressure circuit (e.g., an aortic heart circuit).

Abstract: In one embodiment, a solid state drive (SSD) with power loss protection (PLP) includes a SSD controller, a secondary controller and a power circuit configured to supply power to the SSD from a power source during normal operation and backup power from a backup power source in response to a loss of power supplied by the power source. In the event of a loss of power, the secondary controller is configured to track the holdup time, or duration of time for which the primary controller can operate on backup power. In one embodiment, the holdup time tracked by the secondary controller is stored in a non-volatile memory in communication with the secondary controller.

Abstract: A method and a computer readable medium comprising instructions for upgrading a firmware of a peripheral device connected to a host device via a Peripheral Component Interconnect Express (PCIe) bus from the operating system (OS) of the host device is disclosed. In one embodiment, the method and computer readable medium instructions includes halting host device access to the peripheral device after detecting the peripheral device has completed a shutdown sequence, and resetting the peripheral device after a predetermined time period after completion of the shutdown sequence. The method and computer readable medium instructions further includes initializing the firmware stored in a persistent storage location of the peripheral device, and re-establishing a connection between the peripheral device and the host device. In one embodiment, the predetermined time period is greater than a time it takes for the host device to detect the peripheral device has completed the shutdown sequence.

Abstract: A method and a computer readable medium comprising instructions for upgrading a firmware of a peripheral device connected to a host device via a Peripheral Component Interconnect Express (PCIe) bus from the operating system (OS) of the host device is disclosed. In one embodiment, the method and computer readable medium instructions includes halting host device access to the peripheral device after detecting the peripheral device has completed a shutdown sequence, and resetting the peripheral device after a predetermined time period after completion of the shutdown sequence. The method and computer readable medium instructions further includes initializing the firmware stored in a persistent storage location of the peripheral device, and re-establishing a connection between the peripheral device and the host device. In one embodiment, the predetermined time period is greater than a time it takes for the host device to detect the peripheral device has completed the shutdown sequence.

Abstract: A solid state drive includes a dual buffer for buffering incoming write data prior to committal to a non-volatile memory. The buffer is operated to provide a temporary backup of dirty data pending successful completion of a host transfer. The dual buffer may be operated as a primary buffer and a secondary buffer. The primary buffer may be used as the default buffer during normal operation. The secondary buffer is written to during a host transfer that is a cache write to dirty data. A copying process may be used to copy data between the primary and the secondary buffer to preserve the backup data pending successful completion of the host transfer.

Abstract: On-chip instruction RAM is leveraged as an extension of on-chip data RAM during normal use of a modified Harvard Architecture processor. Unused space in an instruction RAM is detected in a modified Harvard Architecture processor. During operation of the processor this unused space is used to load and store data normally loaded and stored in an on-chip data RAM. A performance penalty associated with swapping out to external memory is reduced. The type of data stored in the unused portion of the instruction RAM may be selected to optimize performance. In one implementation, the unused space in the instruction RAM is used to load and store only a single type of data, such as heap, stack, initialized or uninitialized data.

Abstract: In one embodiment, a solid state drive (SSD) with power loss protection (PLP) includes a SSD controller, a secondary controller and a power circuit configured to supply power to the SSD from a power source during normal operation and backup power from a backup power source in response to a loss of power supplied by the power source. In the event of a loss of power, the secondary controller is configured to track the holdup time, or duration of time for which the primary controller can operate on backup power. In one embodiment, the holdup time tracked by the secondary controller is stored in a non-volatile memory in communication with the secondary controller.

Abstract: A solid state drive includes a dual buffer for buffering incoming write data prior to committal to a non-volatile memory. The buffer is operated to provide a temporary backup of dirty data pending successful completion of a host transfer. The dual buffer may be operated as a primary buffer and a secondary buffer. The primary buffer may be used as the default buffer during normal operation. The secondary buffer is written to during a host transfer that is a cache write to dirty data. A copying process may be used to copy data between the primary and the secondary buffer to preserve the backup data pending successful completion of the host transfer.

Abstract: A solid state drive includes a dual buffer for buffering incoming write data prior to committal to a non-volatile memory. The buffer is operated to provide a temporary backup of dirty data pending successful completion of a host transfer. The dual buffer may be operated as a primary buffer and a secondary buffer. The primary buffer may be used as the default buffer during normal operation. The secondary buffer is written to during a host transfer that is a cache write to dirty data. A copying process may be used to copy data between the primary and the secondary buffer to preserve the backup data pending successful completion of the host transfer.

Abstract: On-chip instruction RAM is leveraged as an extension of on-chip data RAM during normal use of a modified Harvard Architecture processor. Unused space in an instruction RAM is detected in a modified Harvard Architecture processor. During operation of the processor this unused space is used to load and store data normally loaded and stored in an on-chip data RAM. A performance penalty associated with swapping out to external memory is reduced. The type of data stored in the unused portion of the instruction RAM may be selected to optimize performance. In one implementation, the unused space in the instruction RAM is used to load and store only a single type of data, such as heap, stack, initialized or uninitialized data.

Abstract: In a regression modeling system, activation scale values over a plurality of survey participants is used to generate a regression to identify a predictive model that can have a direct explanatory relationship to healthcare utilization and cost. The survey can comprise a number of declarative statements and the responses can be an indication of a participant's level of agreement. The activation scale value for a given individual is thus a predictive dependent variable that can be changed with a known effect on outcomes (independent variables). For example, healthcare utilization and costs will decline as an activation scale value goes up.

Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high pressure circuit (e.g., an aortic heart circuit).

Abstract: A protein-fortified frozen dessert formulation and the process for making it are described. In particular, a sweet mix of 10-20% w/w sugar, 0-10% w/w flavouring, 0-20% w/w fat, 10-15% w/w milk solids, 0-11% w/w protein and 50-65% w/w water is prepared, preheated, pasteurized, homogenized and aged. The aged sweet-mix is then blended with yogurt and optionally more protein prior to freezing. Alternatively, a mix of 10-20% w/w sugar, 0-10% w/w flavouring, 0-20% w/w fat, 10-15% w/w milk solids, 5-15% w/w protein, 5-20% yogurt and 50-65% w/w water is prepared, preheated, pasteurized, homogenize and aged and frozen to a low target overrun.