Patents by Inventor Christopher Demerson

Christopher Demerson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline polymorph of bazedoxifene acetate
    Patent number: 7683051
    Abstract: The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: March 23, 2010
    Assignee: Wyeth
    Inventors: Christopher Demerson, Silvio Iera, Kadum A. Ali
  • Process for the scalable synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]-indole derivatives
    Publication number: 20060058532
    Abstract: The invention is directed to a process of synthesizing compounds of formula (VI): wherein R1-R9, R3?, R4? and Y are as set forth in the specification, and said method is useful for large scale synthesis thereof. The invention is also directed to useful intermediates for synthesizing the compounds of formula (VI) and processes of preparing said intermediates.
    Type: Application
    Filed: September 9, 2005
    Publication date: March 16, 2006
    Inventors: Warren Chew, Gloria Cheal, Jacqueline Lunetta, Christopher Demerson
  • Crystalline polymorph of pipindoxifene hydrochloride monohydrate
    Publication number: 20060030591
    Abstract: The present invention is directed to a crystalline polymorph of pipindoxifene hydrochloride monohydrate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Application
    Filed: August 4, 2005
    Publication date: February 9, 2006
    Applicant: Wyeth
    Inventors: Christopher Demerson, Gloria Cheal
  • Crystalline polymorph of pipindoxifene hydrochloride monohydrate
    Publication number: 20060030711
    Abstract: The present invention is directed to a crystalline polymorph of pipindoxifene hydrochloride monohydrate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Application
    Filed: August 4, 2005
    Publication date: February 9, 2006
    Applicant: Wyeth
    Inventors: Christopher Demerson, Gloria Cheal
  • Preparation and purification of antiviral disulfonic acid disodium salt
    Patent number: 6960686
    Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4?,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2?-disulfonic acid and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: November 1, 2005
    Assignee: Wyeth
    Inventors: Silvio Iera, Christopher A. Demerson, Jacqueline F. Lunetta, Maria Papamichelakis, Michael F. MacEwan, Wayne G. McMahon, John R. Potoski, Arthur G. Mohan, Antonia Nikitenko
  • Crystalline polymorph of bazedoxifene acetate
    Publication number: 20050227965
    Abstract: The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Application
    Filed: April 6, 2005
    Publication date: October 13, 2005
    Applicant: Wyeth
    Inventors: Christopher Demerson, Silvio Iera, Kadum Ali
  • Preparation and purification of antiviral disulfonic acid disodium salt
    Publication number: 20050038026
    Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4?,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2?-disulfonic acid and its pharmaceutically acceptable salts.
    Type: Application
    Filed: September 22, 2004
    Publication date: February 17, 2005
    Applicant: WYETH
    Inventors: Silvio Iera, Christopher Demerson, Jacqueline Lunetta, Maria Papamichelakis, Michael MacEwan, Wayne McMahon, John Potoski, Arthur Mohan
  • Preparation and purification of antiviral disulfonic acid disodium salt
    Patent number: 6806366
    Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: October 19, 2004
    Assignee: Wyeth
    Inventors: Silvio Iera, Christopher A. Demerson, Jacqueline F. Lunetta, Maria Papamichelakis, Michael F. MacEwan, Wayne G. McMahon, John R. Potoski, Arthur G. Mohan
  • Preparation and purification of antiviral disulfonic acid disodium salt
    Publication number: 20020151548
    Abstract: The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.
    Type: Application
    Filed: January 31, 2002
    Publication date: October 17, 2002
    Applicant: American Home Products Corporation
    Inventors: Silvio Iera, Christopher A. Demerson, Jacqueline F. Lunetta, Maria Papamichelakis, Michael F. MacEwan, Wayne G. McMahon, John R. Potoski, Arthur G. Mohan
  • Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA.sub.2 and lipoxygenase
    Patent number: 5420289
    Abstract: This invention relates to substituted indole derivatives possessing lipoxygenase inhibitory, phospholipase A.sub.2 inhibitory and leukotriene antagonist activity, which are useful as anti-inflammatory, antiallergic and cytoprotective agents.
    Type: Grant
    Filed: March 10, 1993
    Date of Patent: May 30, 1995
    Assignee: American Home Products Corporation
    Inventors: John H. Musser, Anthony F. Kreft, III, Amedeo A. Failli, Christopher A. Demerson, Uresh S. Shah, James A. Nelson
  • Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
    Patent number: 5229516
    Abstract: There are disclosed compounds of the formulaA(CH.sub.2).sub.n O-BwhereinA is C.sub.4 -C.sub.8 alkyl, phenoxyethyl, phenoxyphenyl or a group having the formula ##STR1## wherein ##STR2## R.sup.1 is hydrogen, lower alkyl, phenyl or phenyl substituted with trifluoromethyl;R.sup.2 is hydrogen or lower alkyl; orR.sup.1 and R.sup.2 taken together form a benzene ring;R.sup.3 is hydrogen or lower alkyl;n is 1-2;B is ##STR3## wherein ##STR4## m is 0-3; R.sup.5 is ##STR5## or phenyl or phenyl substituted by halo, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl;R.sup.6 is A(CH.sub.2).sub.n O-- or halo; with the proviso that when R.sup.6 is halo, R.sup.5 is ##STR6## R.sup.7 is lower alkyl; Y is --CH.sub.2 -- or --O--;R.sup.8 is lower alkyl or --(CH.sub.2).sub.m CO.sub.2 R.sup.3 ;R.sup.9 is ##STR7## or --CH.sub.2 R.sup.10 ; R.sup.10 is lower alkyl, phenyl, phenyl substituted with carboxy, halo, loweralkylthio or loweralkylsulfinyl, pyridyl, furanyl or quinolinyl;R.sup.
    Type: Grant
    Filed: July 10, 1992
    Date of Patent: July 20, 1993
    Assignee: American Home Products Corporation
    Inventors: John H. Musser, Anthony F. Kreft, III, Amedeo A. Failli, Christopher A. Demerson, Uresh S. Shah, James A. Nelson
  • Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
    Patent number: 4971960
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: February 14, 1989
    Date of Patent: November 20, 1990
    Assignee: American Home Products Corporation
    Inventors: Alan H. Katz, Christopher A. Demerson, Leslie G. Humber
  • Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
    Patent number: 4855445
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-,5-,6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: January 9, 1989
    Date of Patent: August 8, 1989
    Assignee: American Home Products Corporation
    Inventors: Alan H. Katz, Christopher A. Demerson
  • Production of substituted 1,3,4,9-tetrahydropyrano(3,4-B)indole-1-acetic acids
    Patent number: 4826994
    Abstract: Production of indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: May 2, 1989
    Assignee: American Home Products Corporation
    Inventors: Alan H. Katz, Christopher A. Demerson, Leslie G. Humber
  • Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids
    Patent number: 4822781
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: June 1, 1988
    Date of Patent: April 18, 1989
    Assignee: American Home Products
    Inventors: Alan H. Katz, Christopher A. Demerson
  • Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them
    Patent number: 4810699
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1,5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: March 7, 1989
    Assignee: American Home Products Corporation
    Inventors: Joseph P. Sabatucci, Christopher A. Demerson, Amadeo A. Failli
  • Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
    Patent number: 4775690
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: January 13, 1987
    Date of Patent: October 4, 1988
    Assignee: American Home Products Corporation
    Inventors: Alan H. Katz, Christopher A. Demerson, Leslie G. Humber
  • Production of substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives
    Patent number: 4709048
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation. The compounds are useful analgesic and anti-inflammatory agents.
    Type: Grant
    Filed: March 31, 1987
    Date of Patent: November 24, 1987
    Assignee: American Home Products Corp.
    Inventors: Dominick Mobilio, Christopher A. Demerson, Leslie G. Humber
  • Process for preparing substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid
    Patent number: 4701533
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic and antiinflammatory agents.
    Type: Grant
    Filed: February 18, 1987
    Date of Patent: October 20, 1987
    Assignee: American Home Products Corporation
    Inventors: Dominick Mobilio, Christopher A. Demerson, Leslie G. Humber
  • Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid
    Patent number: 4687860
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic and antiinflammatory agents.
    Type: Grant
    Filed: August 26, 1986
    Date of Patent: August 18, 1987
    Assignee: American Home Products Corporation
    Inventors: Dominick Mobilio, Christopher A. Demerson, Leslie G. Humber