Abstract: Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: Unicompartmental tibial components are described herein. A first unicompartmental component (10) comprises a plate (12) having a bearing surface (18) and an opposing surface (22) that is configured to be secured to a proximal end of a patient's tibia, wherein the plate further comprises an anterior end (24), an outer side (25), a posterior end (26) and an inner side (27), wherein a mediolateral width W of the plate is defined between the outer and inner sides, and a longitudinal anteroposterior axis (28) extends between the anterior and posterior ends approximately one third of the width of the plate (i.e. 1/3 W) from the lateral side, and defines a longitudinal axis length L of the plate. A first elongate peg (14) protrudes from the opposing surface in the anterior portion, the first elongate peg defining a first peg axis (32). A second elongate peg (16) protrudes from the opposing surface in the anterior portion, the second elongate peg defining a second peg axis (34).

Abstract: A drain assembly includes a drain body, barrel, plug, and sleeve. The drain body has an interior surface defining a channel along an axis and having interior threads thereon. The barrel has a central body having an upper end, with a flange extending radially outward therefrom and defining a landing surface. The central body has opposed exterior and interior barrel surfaces having exterior and interior threads, respectively. The interior barrel surface defines a channel alignable with the axis. The exterior threads are engageable with the drain body interior threads for axially adjusting the barrel relative to the drain body. The plug has a top surface and an outer body extending axially downward to a stop surface. An inner portion of the outer body extends axially below the stop surface and has external threads engageable with the barrel interior threads. The sleeve is sealingly receivable between the stop and landing surfaces.

Abstract: A ligament assembly comprising a first ligament anchor (9) connected to a second ligament anchor (14) by a ligament (18) a resilient element (40) being associated with the first ligament anchor (9) and a ligament tension adjuster (44, 50) being associated with the second ligament anchor (14). The resilient element (40) may be disposed within the first ligament anchor (9) and the ligament tension adjuster (44, 50) may be disposed within the second ligament anchor (14).

Abstract: A rotary mill comprising a body portion having a milling surface for milling a first bone, a guide portion having a guide body, and inter-engageable guide formations formed on the body portion and guide portion, the guide body having a projection which is adapted to hold a second bone away from the rotary mill during the milling operation.

Abstract: A ligament assembly (2) comprising a resilient element (20) connected to a bone anchor (4) and a ligament (18), the resilient element (20) acting m a cantilever and resisting toads transmitted between the bone anchor (4) and the ligament (18) by virtue of the resistance to bending of the resilient element. The ligament (18) may comprise an artificial ligament (18) which is adapted to replace a human or animal ligament. The resilient element (20) may comprise a spiral spring and may act as a biasing element/shock absorber operatively coupled to the artificial ligament (18) to control the effective stiffness of the artificial ligament (18). Consequently, the resilient element (20) enables an effective stiffness of the artificial ligament (18) to be achieved that more closely approximates the stiffness of a natural ligament.

Abstract: The present disclosure relates to a method for producing metallurgical coke from non-coking coal. The method comprising, densifying, the non-coking coal to form pellets. The densified pellets will be placed in a microwave oven within plurality of bricks and are subjected for pyrolysis. For carrying our pyrolysis, the pellets are carried out by heating, the pellets in the microwave oven at a predetermined temperature under an inert atmosphere at atmospheric pressure, and then the pellets are cooled in the microwave oven under the inert atmosphere. This process coverts non-coking coal to the metallurgical coke in a quicker time, and without use of any susceptors.

Abstract: A patient interface (200, 300) comprising: a seal-forming structure (210, 220, 310, 320) including a face-engaging surface that is personalised to the patient's facial contour and to form a seal with the patient's face at least on or below the bridge of the patient's nose and between the patient's lower lip and on or above the patient's chin, preferably proximal to the patient's mentolabial crease, the face-engaging surface including at least one nare port (211, 311) shaped and sized to align with the patient's nares; an anterior surface (205, 305) including a connection port; wherein the seal-forming structure (210, 220, 310, 320) is non-deformable in response to headgear tension or pressurised air received within the seal-forming structure (210, 220, 310, 320).

Abstract: The present disclosure relates to a method for producing metallurgical coke from non-coking coal. The method comprising, densifying, the non-coking coal to form pellets. The densified pellets will be placed in a microwave oven within plurality of bricks and are subjected for pyrolysis. For carrying our pyrolysis, the pellets are carried out by heating, the pellets in the microwave oven at a predetermined temperature under an inert atmosphere at atmospheric pressure, and then the pellets are cooled in the microwave oven under the inert atmosphere. This process coverts non-coking coal to the metallurgical coke in a quicker time, and without use of any susceptors.

Abstract: A system for a unicompartmental knee replacement is described. The system can include a femoral prosthesis component, a tibial prosthesis component and a meniscal bearing. The meniscal bearing can be insertable between the femoral prosthesis component and the tibial prosthesis component. The meniscal bearing can include a first bearing surface configured to bear against the femoral prosthesis component, a second bearing surface opposed to the first bearing surface and configured to bear against the tibial prosthesis component, and a sidewall separating the first bearing surface from the second bearing surface, wherein the sidewall has a retention groove formed in a portion thereof, and wherein the meniscal bearing and the tibial prosthesis component are configured such that the retaining flange enters the retention groove on movement of the meniscal bearing relative to the tibial prosthesis component towards the medial wall.

Abstract: A heap of a material to be leached to recover a valuable metal from the material includes an electromagnetic heating system to generate heat in situ in the heap.

Abstract: The present disclosure provides an apparatus for treatment of mined material. The apparatus comprises a source for generating electromagnetic radiation and a microwave inlet region for exposing fragments of the mined material to the electromagnetic radiation. Further, the apparatus comprises a reflective structure adjacent the microwave inlet region and providing, or surrounding, a passage for guiding the fragments of the mined material to the microwave inlet region. The reflective structure is arranged to attenuate penetration of the electromagnetic radiation from the microwave inlet region into the passage during throughput of the fragments of the mined material.

Abstract: A ligament assembly (2) comprising a resilient element (20) connected to a bone anchor (4) and a ligament (18), the resilient element (20) acting m a cantilever and resisting toads transmitted between the bone anchor (4) and the ligament (18) by virtue of the resistance to bending of the resilient element. The ligament (18) may comprise an artificial ligament (18) which is adapted to replace a human or animal ligament. The resilient element (20) may comprise a spiral spring and may act as a biasing element/shock absorber operatively coupled to the artificial ligament (18) to control the effective stiffness of the artificial ligament (18). Consequently, the resilient element (20) enables an effective stiffness of the artificial ligament (18) to be achieved that more closely approximates the stiffness of a natural ligament.

Abstract: A rotary mill is disclosed comprising a body portion (4) having a milling surface (10) and a central bore (30) extending along an axis of rotation (18) of the body portion (4); and a guide portion (6) having a guide body (22) and a guide peg (24) extending from the guide body (22), the guide peg (24) operable to be received in the central bore (20) of the body portion (4), the guide body (22) having at least one alignment feature (28, 30) which is the same as that of a prosthesis component.

Abstract: A bearing component 2 for a joint replacement prosthesis comprises a first bearing element 4; a second bearing element 6, and a linking element 8, operatively connecting the first and second bearing elements 4, 6 and permitting relative motion there between. The flexible linking element 8 prevents dislocation of mobile bearings in a total knee replacement prosthesis. The invention also relates to a bridging element which retains the linking element 8 with some play, which acts as a ligament support 2051, and which causes a deflection of the line of action of a ligament 1018. A joint replacement prosthesis is also disclosed comprising a biasing element 1140 or a tensioning element 1220 operatively coupled to the artificial ligament 1018. The biasing element 1140 or tensioning element 1220 may be housed in the stem of a tibia tray 1006.

Abstract: A prosthesis (100, 200) comprising a bone attachment component (106) having one or more fixation structures (124, 224), wherein the prosthesis is configured to be selectively convertible between a mobile bearing prosthesis, in which a barrier (120) is secured to the bone attachment component (106) using the fixation structures, and a constrained bearing prosthesis, in which a bearing component (204) is secured to the bone attachment component (106) using the fixation structures (124, 224).

Abstract: A ligament assembly (2) comprising a resilient element (20) connected to a bone anchor (4) and a ligament (18), the resilient element (20) acting m a cantilever and resisting toads transmitted between the bone anchor (4) and the ligament (18) by virtue of the resistance to bending of the resilient element. The ligament (18) may comprise an artificial ligament (18) which is adapted to replace a human or animal ligament. The resilient element (20) may comprise a spiral spring and may act as a biasing element/shock absorber operatively coupled to the artificial ligament (18) to control the effective stiffness of the artificial ligament (18). Consequently, the resilient element (20) enables an effective stiffness of the artificial ligament (18) to be achieved that more closely approximates the stiffness of a natural ligament.

Abstract: A ligament assembly comprising a first ligament anchor (9) connected to a second ligament anchor (14) by a ligament (18) a resilient element (40) being associated with the first ligament anchor (9) and a ligament tension adjuster (44, 50) being associated with the second ligament anchor (14). The resilient element (40) may be disposed within the first ligament anchor (9) and the ligament tension adjuster (44, 50) may be disposed within the second ligament anchor (14).

Abstract: A seal-forming structure (91) for treating sleep disordered breathing by delivering breathable gas to an entrance of a patient's airways during sleep at a pressure elevated above atmospheric pressure in a range of 4 to 20 cm H2O, the seal-forming structure (91) comprising: a face-engaging surface (95) that is personalised to a patient's facial contour and to form a seal with the patient's face; and at least one comfort region (75, 80) configured to provide substantially even contact pressure between the face-engaging surface (95) against the patient's face when headgear tension is applied in use for maintaining the position of the seal-forming structure (91) on the patient's face; wherein the seal-forming structure (91) is non-deformable in response to headgear tension or pressurised air received within the seal-forming structure (91).

Abstract: A ligament assembly comprising a first ligament anchor (9) connected to a second ligament anchor (14) by a ligament (18) a resilient element (40) being associated with the first ligament anchor (9) and a ligament tension adjuster (44, 50) being associated with the second ligament anchor (14). The resilient element (40) may be disposed within the first ligament anchor (9) and the ligament tension adjuster (44, 50) may be disposed within the second ligament anchor (14).