Abstract: An autonomous vehicle includes one or more sensors for detecting an object in an environment surrounding the autonomous vehicle and a vehicle computing system comprising one or more processors receiving canonical route data associated with at least one canonical route, and controlling travel of the autonomous vehicle based on sensor data from the one or more sensors and the canonical route data associated with the at least one canonical route. The at least one canonical route comprises at least one roadway connected with another roadway in a plurality of roadways in a geographic location that satisfies at least one route optimization function derived based on trip data associated with one or more traversals of the plurality of roadways in a geographic location by one or more autonomous vehicles.

Abstract: The invention relates to systems and methods for providing modular and configurable smart contracts for blockchain applications. The smart contracts may be utilized to retain all transaction attribute values in a world state database of the blockchain-implemented ledger. The systems and methods can further provide for dynamically configurable validation metadata and validation rules for transaction attributes recorded on a blockchain transaction log. The validation metadata and validation rules corresponding to the transaction attributes can be dynamically updated and applied to the transaction attributes to validate or invalidate a transaction.

Abstract: A device obtains prescription information relating to a medication in a container. The device causes a camera device of the device to obtain image data relating to the medication and a weighing device of the device to obtain weight data relating the medication. The device sends the prescription information, the image data, and the weight data to a different device to cause the different device to verify the medication using a machine learning model. The device receives information concerning the medication and automatically generates, based on the information concerning the medication, a message concerning the medication, wherein the message includes instructions on how much of the medication a user of the device is to take. The device causes the device or an additional device to present the message.

Abstract: The present disclosure methods and kits for use of stimulator of interferon genes (STING) agonist compounds, such as cyclic dinucleotides, amidobenzimidazoles, and benzothiophenes, in the treatment and prevention of pain, such as neuropathic pain, inflammatory pain, and cancer pain. Combination therapies and pharmaceutical formulations for treating of pain are also described.

Abstract: The invention relates to systems and methods for providing modular and configurable smart contracts for blockchain applications. The smart contracts may be utilized to retain all transaction attribute values in a world state database of the blockchain-implemented ledger. The systems and methods can further provide for dynamically configurable validation metadata and validation rules for transaction attributes recorded on a blockchain transaction log. The validation metadata and validation rules corresponding to the transaction attributes can be dynamically updated and applied to the transaction attributes to validate or invalidate a transaction.

Abstract: The invention relates to systems and methods for providing modular and configurable smart contracts for blockchain applications. The smart contracts may be utilized to retain all transaction attribute values in a world state database of the blockchain-implemented ledger. The systems and methods can further provide for dynamically configurable validation metadata and validation rules for transaction attributes recorded on a blockchain transaction log. The validation metadata and validation rules corresponding to the transaction attributes can be dynamically updated and applied to the transaction attributes to validate or invalidate a transaction.

Abstract: The invention relates to systems and methods for providing modular and configurable smart contracts for blockchain applications. The smart contracts may be utilized to retain all transaction attribute values in a world state database of the blockchain-implemented ledger. The systems and methods can further provide for dynamically configurable validation metadata and validation rules for transaction attributes recorded on a blockchain transaction log. The validation metadata and validation rules corresponding to the transaction attributes can be dynamically updated and applied to the transaction attributes to validate or invalidate a transaction.

Abstract: A self-learning system for analytical attribute and clustering segmentation may be provided. A text classifier may identify a log description of a log entry in response to text of the log description being associated with indicators of a word model. A datafield classifier may generate a datafield metrics including an accuracy value of the attribute identifiers representing the datafield. A metafield classifier may generate a context metrics for the context of the log entry, the context metrics including an accuracy value of the attribute identifiers representing the metafields. A combination classifier may form a weighted classification set and select an attribute identifier as being representative of the datafield based on the weighted classification set. The combination classifier may further evaluate an attribute importance value of each attribute identifier, and select an attribute identifier having a top attribute importance value.

Abstract: Disclosed herein are methods to treat a neurodegenerative disease comprising administering to a subject with a neurodegenerative disease a therapeutically effective amount of a polynucleotide that binds a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide can aggregate in cells and is associated with a neurodegenerative disease. Also disclosed are methods to inhibit protein aggregation in a cell comprising contacting the cell with a composition comprising a polynucleotide that binds a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide can aggregate in cells and is associated with a neurodegenerative disease. Additionally disclosed are compositions comprising a polynucleotide that binds a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide can aggregate in cells and is associated with a neurodegenerative disease.

Abstract: A self-learning system for analytical attribute and clustering segmentation may be provided. A text classifier may identify a log description of a log entry in response to text of the log description being associated with indicators of a word model. A datafield classifier may generate a datafield metrics including an accuracy value of the attribute identifiers representing the datafield. A metafield classifier may generate a context metrics for the context of the log entry, the context metrics including an accuracy value of the attribute identifiers representing the metafields. A combination classifier may form a weighted classification set and select an attribute identifier as being representative of the datafield based on the weighted classification set. The combination classifier may further evaluate an attribute importance value of each attribute identifier, and select an attribute identifier having a top attribute importance value.

Abstract: A device obtains prescription information relating to a medication in a container. The device causes a camera device of the device to obtain image data relating to the medication and a weighing device of the device to obtain weight data relating the medication. The device sends the prescription information, the image data, and the weight data to a different device to cause the different device to verify the medication using a machine learning model. The device receives information concerning the medication and automatically generates, based on the information concerning the medication, a message concerning the medication, wherein the message includes instructions on how much of the medication a user of the device is to take. The device causes the device or an additional device to present the message.

Abstract: A device obtains prescription information relating to a medication in a container. The device causes a camera device of the device to obtain image data relating to the medication and a weighing device of the device to obtain weight data relating the medication. The device sends the prescription information, the image data, and the weight data to a different device to cause the different device to verify the medication using a machine learning model. The device receives information concerning the medication and automatically generates, based on the information concerning the medication, a message concerning the medication, wherein the message includes instructions on how much of the medication a user of the device is to take. The device causes the device or an additional device to present the message.

Abstract: Disclosed herein are methods for monitoring expression of C9ORF72 mRNA and protein in an animal with C9ORF72 specific inhibitors. Such C9ORF72 specific inhibitors include antisense compounds.

Abstract: Disclosed herein are methods for monitoring expression of C9ORF72 mRNA and protein in an animal with C9ORF72 specific inhibitors. Such C9ORF72 specific inhibitors include antisense compounds.

Abstract: An improved multi-layer optical filter arrangement having spatially and spectrally differential reflection characteristics on one side and substantially uniform transmission characteristics over a band of at least 250 nm in the optical spectrum is provided. The filter arrangement includes two optical thin film stacks disposed on the surface of a substrate in a side by side relationship. Each of the thin film stacks includes two metal layers and a dielectric layer interposed between the two metal layers. At least one of the stacks includes an additional dielectric layer deposited thereon. In addition, one or more matching dielectric layers may be interposed between the substrate and first metal layer of each of the stacks to reduce reverse reflection of the filter arrangement. A semi-continuous process for producing the filter arrangements on flexible films is also included.