Abstract: A solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and processes for preparing the solid dispersion are provided herein. Also, a pharmaceutical composition comprising a solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and uses thereof are provided herein.

Abstract: Behavioral intervention improves the efficacy of treatments designed to encourage healthy behaviors such as smoking cessation, adherence to food regimen after surgeries, and avoiding overeating. Aspects of the present disclosure relate to a health monitoring system that leverages wearable sensors, mobile devices (e.g. smartphones), and computer-based servers to monitor the health of a user and provide intervention at opportune moments to encourage healthy behavior. This system provides a scalable and cost-efficient way for health care providers to monitor the behavior of many users and encourage healthy behavior as appropriate.

Abstract: A solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and processes for preparing the solid dispersion are provided herein. Also, a pharmaceutical composition comprising a solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and uses thereof are provided herein.

Abstract: Two versions of an isolated single stage converter AC/DC Power Factor Corrected (PFC) converter topology have been invented. One is with a full bridge rectifier at its input and the other is a True Bridgeless version. The two versions of the topology feature new configurations and circuitry including a simplified damper circuit and a clamp capacitor flipping circuit and control methods that allow them to realize improved single stage isolated power factor converters which are suitable for high power operation, features Zero Voltage Switching to maximize conversion efficiency and to minimize ElectroMagnetic Interference generation, does not need an additional circuit to limit the inrush current, achieves reasonably low input current Total Harmonic Distortion (THD), and is easy to control. The second version provides a true bridgeless single stage isolated power factor converter with even higher efficiency and lower input current THD.

Abstract: Two versions of an isolated single stage converter AC/DC Power Factor Corrected (PFC) converter topology have been invented. One is with a full bridge rectifier at its input and the other is a True Bridgeless version. The two versions of the topology feature new configurations and circuitry including a simplified damper circuit and a clamp capacitor flipping circuit and control methods that allow them to realize improved single stage isolated power factor converters which are suitable for high power operation, features Zero Voltage Switching to maximize conversion efficiency and to minimize ElectroMagnetic Interference generation, does not need an additional circuit to limit the inrush current, achieves reasonably low input current Total Harmonic Distortion (THD), and is easy to control. The second version provides a true bridgeless single stage isolated power factor converter with even higher efficiency and lower input current THD.

Abstract: Two versions of an isolated single stage converter AC/DC Power Factor Corrected (PFC) converter topology have been invented. One is with a full bridge rectifier at its input and the other is a True Bridgeless version. The two versions of the topology feature new configurations and circuitry including a simplified damper circuit and a clamp capacitor flipping circuit and control methods that allow them to realize improved single stage isolated power factor converters which are suitable for high power operation, features Zero Voltage Switching to maximize conversion efficiency and to minimize Electro-Magnetic Interference generation, does not need an additional circuit to limit the inrush current, achieves reasonably low input current Total Harmonic Distortion (THD), and is easy to control. The second version provides a true bridgeless single stage isolated power factor converter with even higher efficiency and lower input current THD.

Abstract: A solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and processes for preparing the solid dispersion are provided herein. Also, a pharmaceutical composition comprising a solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and uses thereof are provided herein.

Abstract: Two versions of an isolated single stage converter AC/DC Power Factor Corrected (PFC) converter topology have been invented. One is with a full bridge rectifier at its input and the other is a True Bridgeless version. The two versions of the topology feature new configurations and circuitry including a simplified damper circuit and a clamp capacitor flipping circuit and control methods that allow them to realize improved single stage isolated power factor converters which are suitable for high power operation, features Zero Voltage Switching to maximize conversion efficiency and to minimize Electro-Magnetic Interference generation, does not need an additional circuit to limit the inrush current, achieves reasonably low input current Total Harmonic Distortion (THD), and is easy to control. The second version provides a true bridgeless single stage isolated power factor converter with even higher efficiency and lower input current THD.

Abstract: Two versions of an isolated single stage converter AC/DC Power Factor Corrected (PFC) converter topology have been invented. One is with a full bridge rectifier at its input and the other is a True Bridgeless version. The two versions of the topology feature new configurations and circuitry including a simplified damper circuit and a clamp capacitor flipping circuit and control methods that allow them to realize improved single stage isolated power factor converters which are suitable for high power operation, features Zero Voltage Switching to maximize conversion efficiency and to minimize Electro-Magnetic Interference generation, does not need an additional circuit to limit the inrush current, achieves reasonably low input current Total Harmonic Distortion (THD), and is easy to control. The second version provides a true bridgeless single stage isolated power factor converter with even higher efficiency and lower input current THD.

Abstract: Behavioral intervention improves the efficacy of treatments designed to encourage healthy behaviors such as smoking cessation, adherence to food regimen after surgeries, and avoiding overeating. Aspects of the present disclosure relate to a health monitoring system that leverages wearable sensors, mobile devices (e.g. smartphones), and computer-based servers to monitor the health of a user and provide intervention at opportune moments to encourage healthy behavior. This system provides a scalable and cost-efficient way for health care providers to monitor the behavior of many users and encourage healthy behavior as appropriate.

Abstract: A solid dispersion of N4-(4-([1,2,4]triazolo[1,5-?]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and processes for preparing the solid dispersion are provided herein. Also, a pharmaceutical composition comprising a solid dispersion of N4-(4-([1,2,4]triazolo[1,5-?]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and uses thereof are provided herein.

Abstract: Two versions of an isolated single stage converter AC/DC Power Factor Corrected (PFC) converter topology have been invented. One is with a full bridge rectifier at its input and the other is a True Bridgeless version. The two versions of the topology feature new configurations and circuitry including a simplified damper circuit and a clamp capacitor flipping circuit and control methods that allow them to realize improved single stage isolated power factor converters which are suitable for high power operation, features Zero Voltage Switching to maximize conversion efficiency and to minimize Electro-Magnetic Interference generation, does not need an additional circuit to limit the inrush current, achieves reasonably low input current Total Harmonic Distortion (THD), and is easy to control. The second version provides a true bridgeless single stage isolated power factor converter with even higher efficiency and lower input current THD.

Abstract: A solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and processes for preparing the solid dispersion are provided herein. Also, a pharmaceutical composition comprising a solid dispersion of N4-(4-([1,2,4]triazolo[1,5-?]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and uses thereof are provided herein.

Abstract: Overload of a source included in a network is prevented. Each packet of a plurality of packets is transmitted, via the network, between at least one source and at least one intended destination. The network is interfaced between each of the at least one source and each of the at least one intended destination. Each packet of at least a subset of packets of the plurality of packets is intercepted at the interfacing. For each intercepted packet, it is determined whether the intercepted packet is transmitted from one source to one intended destination or is transmitted from one intended destination to one source. For each of the at least one intended destination, each intercepted packet transmitted thereto or received therefrom is accounted based on the determining. An action is taken based on the accounting.

Abstract: A solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and processes for preparing the solid dispersion are provided herein. Also, a pharmaceutical composition comprising a solid dispersion of N4-(4-([1,2,4]triazolo[1,5-?]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and uses thereof are provided herein.

Abstract: The present invention provides methods, dosage forms and kits for treating with an effective amount of ziprasidone a CNS disorder in a human when the human is in a fasted state. In one embodiment, the invention relates to a method for treating a CNS disorder in a human, which method comprises administering to the human in a fasted state, a solid oral dosage form comprising an amount of ziprasidone effective to treat said CNS disorder, wherein the area under the serum concentration versus time curve (AUC0-inf) of the ziprasidone in the human subsequent to said administering is from 70% to 140% of the mean area under the ziprasidone serum concentration versus time curve (AUC0-inf) resulting from administration of a control ziprasidone immediate release oral capsule containing the same amount of ziprasidone to a cohort of humans in a fed state.

Abstract: A buck derived isolated DC-DC converter includes a half or full bridge of switching devices which are asymmetrically controlled so that top and bottom switches are opened and closed at mutually exclusive times. Primary side and secondary side DC blocking capacitor(s) and a small valued inductor are placed in series with an isolation transformer. A single secondary rectification uncontrolled switch and inductor-capacitor output filter are included. Additionally a voltage clamping circuit is added across the rectifier which includes an active switch which also may be connected to a tap on the output inductor.