Patents by Inventor Christopher E. Heise

Christopher E. Heise has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDE ANTIBIOTIC COMPLEXES AND METHODS OF USE THEREOF
    Publication number: 20200262869
    Abstract: Provided herein are compounds that form covalent bonds with peptidases, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SPase), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Application
    Filed: March 25, 2020
    Publication date: August 20, 2020
    Inventors: PETER ANDREW SMITH, JEREMY MARK MURRAY, MICHAEL FRIEDRICH THOMAS KOEHLER, CHRISTOPHER E. HEISE
  • Lysophosphatidic acid receptor agonists and antagonists
    Patent number: 7169818
    Abstract: The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of selectivity at individual LPA receptors (i.e. LPA1, LPA2 and LPA3). More particularly the present invention is directed to LPA analogs wherein the glycerol is replaced with ethanolamine and a variety of substitutions have been linked at the second carbon atom.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: January 30, 2007
    Assignee: University of Virginia Patent Foundation
    Inventors: Kevin R. Lynch, Timothy L. Macdonald, Christopher E. Heise, Webster L. Santos, Mark D. Okusa
  • Novel lysophosphatidic acid receptor agonists and antagonists
    Publication number: 20040122236
    Abstract: The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of selectivity at individual LPA receptors (i.e. LPA1, LPA2 and LPA3). More particularly the present invention is directed to LPA analogs wherein the glycerol is replaced with ethanolamine and a variety of substitutions have been linked at the second carbon atom.
    Type: Application
    Filed: October 15, 2003
    Publication date: June 24, 2004
    Inventors: Kevin R. Lynch, Timothy L Macdonald, Christopher E Heise, Webster L Santos, Mark D Okusa