Patents by Inventor Christopher E. HENDERSON

Christopher E. HENDERSON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying candidates for the treatment of neurodegenerative diseases
    Patent number: 9733237
    Abstract: The present invention provides, inter alia, methods for identifying a candidate agent that may be effective to treat or ameliorate an effect of a neurodegenerative disease in a subject. These methods include: (a) contacting a wildtype neuron and a mutant neuron with a stressor which is effective to accelerate the degeneration of the mutant neuron; (b) further contacting the wildtype neuron and the mutant neuron from step (a) with a candidate agent; and (c) determining whether the candidate agent lowers a wildtype to mutant survival ratio or increases both wildtype and mutant neuron survival.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: August 15, 2017
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Hynek Wichterle, Christopher E Henderson, Sebastian Thams
  • METHODS FOR IDENTIFYING CANDIDATES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20150285788
    Abstract: The present invention provides, inter alia, methods for identifying a candidate agent that may be effective to treat or ameliorate an effect of a neurodegenerative disease in a subject. These methods include: (a) contacting a wildtype neuron and a mutant neuron with a stressor which is effective to accelerate the degeneration of the mutant neuron; (b) further contacting the wildtype neuron and the mutant neuron from step (a) with a candidate agent; and (c) determining whether the candidate agent lowers a wildtype to mutant survival ratio or increases both wildtype and mutant neuron survival.
    Type: Application
    Filed: October 31, 2013
    Publication date: October 8, 2015
    Inventors: Hynek WICHTERLE, Christopher E. HENDERSON, Sebastian THAMS