Patents by Inventor Christopher E. Hopkins

Christopher E. Hopkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200064335
    Abstract: Systems and methods relate to transgenic organisms and their use as biosensors are described. In some embodiments, the systems and methods include a first population of transgenic organisms that includes a first constitutively expressed reporter gene, and a first transgene that includes a first inducible promoter from a response pathway gene, wherein the first inducible promoter is coupled to a first reporter gene. Other embodiments are described.
    Type: Application
    Filed: March 24, 2018
    Publication date: February 27, 2020
    Applicant: KDT, Inc.
    Inventors: Christopher E. Hopkins, Miluka Gunaratna
  • Publication number: 20200060246
    Abstract: The present disclosure provides transgenic nematode systems for assessing function of heterologous genes, their variants and drug discovery. The transgenic nematodes contain a heterologous gene that is inserted via homologous recombination at the native locus replacing and removing the nematode ortholog, wherein expression of the heterologous gene rescues function of the removed nematode ortholog and a transgenic control animal is provided. The heterologous gene may be further modified to provide a variant, such as a human clinical variant, whereby a transgenic test animal is provided. Those transgenic test animals are used in methods to assess function of the heterologous variant and drug screens to find therapeutic candidates reversing deviant activity back to wildtype.
    Type: Application
    Filed: February 21, 2019
    Publication date: February 27, 2020
    Applicant: NemaMetrix Inc.
    Inventors: Christopher E. Hopkins, Trisha J. Brock, Kathryn McCormick, Gongping He
  • Patent number: 9933412
    Abstract: Systems and methods relate to transgenic organisms and their use as biosensors are described. In some embodiments, the systems and methods include a first population of transgenic organisms that includes a first constitutively expressed reporter gene, and a first transgene that includes a first inducible promoter from a response pathway gene, wherein the first inducible promoter is coupled to a first reporter gene. Other embodiments are described.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: April 3, 2018
    Assignee: KDT, Inc.
    Inventors: Christopher E. Hopkins, Miluka Gunaratna
  • Publication number: 20150204849
    Abstract: Systems and methods relate to transgenic organisms and their use as biosensors are described. In some embodiments, the systems and methods include a first population of transgenic organisms that includes a first constitutively expressed reporter gene, and a first transgene that includes a first inducible promoter from a response pathway gene, wherein the first inducible promoter is coupled to a first reporter gene. Other embodiments are described.
    Type: Application
    Filed: December 9, 2014
    Publication date: July 23, 2015
    Inventors: Christopher E. Hopkins, Miluka Gunaratna
  • Patent number: 8937213
    Abstract: Systems and methods relate to transgenic organisms and their use as biosensors are described. In some embodiments, the systems and methods include a first population of transgenic organisms that includes a first constitutively expressed reporter gene, and a first transgene that includes a first inducible promoter from a response pathway gene, wherein the first inducible promoter is coupled to a first reporter gene. Other embodiments are described.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: January 20, 2015
    Inventors: Christopher E. Hopkins, Miluka Gunaratna
  • Publication number: 20120325152
    Abstract: Compositions for nematode growth and methods for using the same for nematode viability are described. The compositions contain a solid matrix material that is dispersed in a liquid medium. The solid matrix can be immersed, bathed, and/or interspersed in a liquid medium to form a composite culture that is capable of maintaining or growing nematodes at unexpectedly high densities and/or with nominal stress pathway activity. Other embodiments are described.
    Type: Application
    Filed: June 22, 2012
    Publication date: December 27, 2012
    Inventors: Christopher E. Hopkins, John P. Manfredi
  • Publication number: 20120304320
    Abstract: Systems and methods relate to transgenic organisms and their use as biosensors are described. In some embodiments, the systems and methods include a first population of transgenic organisms that includes a first constitutively expressed reporter gene, and a first transgene that includes a first inducible promoter from a response pathway gene, wherein the first inducible promoter is coupled to a first reporter gene. Other embodiments are described.
    Type: Application
    Filed: May 21, 2012
    Publication date: November 29, 2012
    Inventors: Christopher E. Hopkins, Miluka Gunaratna
  • Publication number: 20120208291
    Abstract: Disclosed herein are methods and compositions relating to the detection and measuring of kinetic binding interactions.
    Type: Application
    Filed: April 30, 2010
    Publication date: August 16, 2012
    Applicant: Univeristy of Utah Research Foundation
    Inventors: M. Wayne Davis, Erik M. Jorgensen, Joel M. Harris, Christopher E. Hopkins, Joshua R. Wayment, Eric Peterson, Douglas Michael Kriech
  • Patent number: 5383107
    Abstract: A control unit for an inverter determines an objective function based upon harmonic content in a minimum number of the phase-to-phase AC voltages produced by the inverter and controls the switches of the inverter so as to minimize the objective function to thus control the harmonic content in the inverter output voltages.The objective function may be defined according to the following equation: ##EQU1## where W.sub.k are scaler weighting factors, A.sub.kA, A.sub.kB and A.sub.kC are the Fourier cosine coefficients of the kth harmonic of the inverter phase A, B and C outputs, B.sub.kA, B.sub.kB and B.sub.kC are the Fourier sine coefficients of the kth harmonic of the inverter phase A, B and C outputs, k is the number of the controlled odd harmonic (i.e., k=1, 3, 5 . . . ), and NHARM is the number of the highest controlled odd harmonic.
    Type: Grant
    Filed: November 6, 1992
    Date of Patent: January 17, 1995
    Assignee: Sundstrand Corporation
    Inventors: Christopher E. Hopkins, Albert L. Markunas, Vijay K. Maddali, Richard A. Arbanella