Abstract: The invention provides for the treatment of mutant epidermal growth factor receptor (EGFR) mediated cancer that has metastasized to the brain or other area of the central nervous system with a compound that degrades a mutant form of EGFR via the ubiquitination of the EGFR protein and subsequent proteasomal degradation. The invention also provides advantageous drug combinations for the treatment of such cancer that include a compound herein that degrades a mutant form of EGFR in combination with a second anti-cancer agent.

Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: The invention provides compounds that degrade the epidermal growth factor receptor (EGFR) including mutant forms via the ubiquitination of the EGFR protein and subsequent proteasomal degradation. The compounds are useful for the treatment of various cancers.

Abstract: A laser radar system and a method for use in a laser radar system are disclosed. More particularly, the laser radar system includes a fiber laser capable of generating a laser signal; a first optical path through which the generated laser signal may be transmitted; a second optical path through which a reflection of the transmitted laser signal may be received; and a detector capable of detecting the received reflection. The method includes generating a laser signal from a fiber laser; transmitting the laser signal; receiving a reflection of the transmitted laser signal; and detecting the reflection.

Abstract: A laser radar system and a method for use in a laser radar system are disclosed. More particularly, the laser radar system includes a fiber laser capable of generating a laser signal; a first optical path through which the generated laser signal may be transmitted; a second optical path through which a reflection of the transmitted laser signal may be received; and a detector capable of detecting the received reflection. The method includes generating a laser signal from a fiber laser; transmitting the laser signal; receiving a reflection of the transmitted laser signal; and detecting the reflection.