Patents by Inventor Christopher E. Ramsden

Christopher E. Ramsden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gingerenone A prodrugs as sensotherapeutics and methods of use
    Patent number: 12325688
    Abstract: Gingerenone A prodrug compounds have a structure according to Formula I, or a pharmaceutically acceptable salt thereof wherein one of R1 and R2 is H or —C(O)—R and the other of R1 and R2 is —C(O)—R. Each R independently is RA or, where RA is C18-C22 alkenyl, and RB is an amino acid side chain. The compounds are useful for inhibiting or eliminating senescence. The compounds may be administered to a subject having a senescence-associated disease or disorder, neuroinflammation, pain, and/or an amino acid deficiency.
    Type: Grant
    Filed: January 17, 2023
    Date of Patent: June 10, 2025
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Ruin Moaddel, Luigi Ferrucci, Kotb Abdelmohsen, Myriam Gorospe, Martina Rossi, Christopher E. Ramsden, Gregory S. Keyes
  • GINGERENONE A PRODRUGS AS SENSOTHERAPEUTICS AND METHODS OF USE
    Publication number: 20250115543
    Abstract: Gingerenone A prodrug compounds have a structure according to Formula I, or a pharmaceutically acceptable salt thereof wherein one of R1 and R2 is H or —C(O)—R and the other of R1 and R2 is —C(O)—R. Each R independently is RA or, where RA is C18-C22 alkenyl, and RB is an amino acid side chain. The compounds are useful for inhibiting or eliminating senescence. The compounds may be administered to a subject having a senescence-associated disease or disorder, neuroinflammation, pain, and/or an amino acid deficiency.
    Type: Application
    Filed: January 17, 2023
    Publication date: April 10, 2025
    Applicant: The U.S.A., as Represented by the Secretary, Department of Health and Human Services
    Inventors: Ruin Moaddel, Luigi Ferrucci, Kotb Abdelmohsen, Myriam Gorospe, Martina Rossi, Christopher E. Ramsden, Gregory S. Keyes
  • GINGERENONE A PRODRUGS AND METHODS OF USE
    Publication number: 20240374550
    Abstract: Gingerenone A prodrug compounds have a structure according to Formula I, or a pharmaceutically acceptable salt thereof wherein one of R1 and R2 is H or —C(O)—R and the other of R1 and R2 is —C(O)—R. Each R independently is RA or where RA is C18-C22 alkenyl, and RB is an amino acid side chain. The compounds are useful for inhibiting or eliminating senescence, reducing a level of interleukin-2 (IL-2), reducing a level of interleukin-5 (IL-5), increasing a level of a metabolite that exerts an antioxidant effect, increasing a level of an RA-containing lipid, or any combination thereof. The compounds may be administered to a subject having a senescence-associated disease or disorder, neuroinflammation, pain, an amino acid deficiency, atopy, itch, or any combination thereof.
    Type: Application
    Filed: July 23, 2024
    Publication date: November 14, 2024
    Applicant: The U.S.A., as Represented by the Secretary, Department of Health and Human Services
    Inventors: Ruin Moaddel, Luigi Ferrucci, Christopher E. Ramsden, Gregory S. Keyes