Abstract: A cervical cell collection device, kit and method for the collection of cervical cells is provided. In some embodiments, the cervical cell collection device comprises an outer guide assembly having a distal end section with an aperture there through; an inner assembly positioned within the outer guide assembly, the inner assembly having a distal end with a collapsible collection pad secured thereto by a flexible collection support, wherein the inner assembly is movable from a first position where the collection pad is folded inside distal end section of the outer guide assembly to a second position where the collection pad is pushed through the aperture in the distal end of the outer guide assembly where it expands to contact and collect cervical cells.

Abstract: A cervical cell collection device, kit and method for the collection of cervical cells is provided. In some embodiments, the cervical cell collection device comprises an outer guide assembly having a distal end section with an aperture there through; an inner assembly positioned within the outer guide assembly, the inner assembly having a distal end with a collapsible collection pad secured thereto by a flexible collection support, wherein the inner assembly is movable from a first position where the collection pad is folded inside distal end section of the outer guide assembly to a second position where the collection pad is pushed through the aperture in the distal end of the outer guide assembly where it expands to contact and collect cervical cells.

Abstract: A cervical cell collection device, kit and method for the collection of cervical cells is provided. In some embodiments, the cervical cell collection device comprises an outer guide assembly having a distal end section with an aperture there through; an inner assembly positioned within the outer guide assembly, the inner assembly having a distal end with a collapsible collection pad secured thereto by a flexible collection support, wherein the inner assembly is movable from a first position where the collection pad is folded inside distal end section of the outer guide assembly to a second position where the collection pad is pushed through the aperture in the distal end of the outer guide assembly where it expands to contact and collect cervical cells.

Abstract: Systems and methods for detection of analytes by production of electrochemical species are provided. Some embodiments of this invention relate generally to carbon biosensors for detecting an analyte in a biological sample. More specifically, this invention relates generally to immunoassays for detection of analytes utilizing electroactive compounds, and more particularly, relates to diagnostic assays based on signals from electroactive chemical undergoing redox cycling on electrosensor consisting of carbon, to detect analytes wherein a precomplex mixture is formed and a multi-step, or single-step, assay is performed, resulting in greater signal.

Abstract: For various embodiments of a printhead assembly or ink stick assembly of the present teachings, each an ink stick assembly can be a self-contained assembly, of which a plurality of self-contained ink stick assemblies can be readily interchanged into a printing system during a printing process. Various embodiments of a self-contained ink stick assembly can have a fluidic system that can include a local ink reservoir, which can be in fluid communication with a bulk ink reservoir. Filling of a bulk ink reservoir can be done in a manual or automated mode. According to the present teachings, a bulk ink reservoir can have a volume sufficient to provide a continuous supply of ink to a local ink reservoir over the course of a printing process.

Abstract: For various embodiments of a printhead assembly or ink stick assembly of the present teachings, each an ink stick assembly can be a self-contained assembly, of which a plurality of self-contained ink stick assemblies can be readily interchanged into a printing system during a printing process. Various embodiments of a self-contained ink stick assembly can have a fluidic system that can include a local ink reservoir, which can be in fluid communication with a bulk ink reservoir. Filling of a bulk ink reservoir can be done in a manual or automated mode. According to the present teachings, a bulk ink reservoir can have a volume sufficient to provide a continuous supply of ink to a local ink reservoir over the course of a printing process.

Abstract: Optical readers and alignment tools for detecting the level of an analyte. Described herein are small, disposable partially-encapsulated sensing chips for detecting an analyte level from a fluid sample (e.g., a blood sample) having an edge of the integrated sensing chip exposed to directly expose a plurality of excitation and a collection waveguides, as well as optical readers and methods of operating them. A fluid sample maybe applied to a sensing surface of the sensing chip in the housing so that an analyte level can be optically detected. Also described are methods of sensing an analyte using these devices and systems including an optical detector.

Abstract: Systems and methods for detection of analytes by production of electrochemical species are provided. Some embodiments of this invention relate generally to carbon biosensors for detecting an analyte in a biological sample. More specifically, this invention relates generally to immunoassays for detection of analytes utilizing electroactive compounds, and more particularly, relates to diagnostic assays based on signals from electroactive chemical undergoing redox cycling on electrosensor consisting of carbon, to detect analytes wherein a precomplex mixture is formed and a multi-step, or single-step, assay is performed, resulting in greater signal.

Abstract: For various embodiments of a printhead assembly or ink stick assembly of the present teachings, each an ink stick assembly can be a self-contained assembly, of which a plurality of self-contained ink stick assemblies can be readily interchanged into a printing system during a printing process. Various embodiments of a self-contained ink stick assembly can have a fluidic system that can include a local ink reservoir, which can be in fluid communication with a bulk ink reservoir. Filling of a bulk ink reservoir can be done in a manual or automated mode. According to the present teachings, a bulk ink reservoir can have a volume sufficient to provide a continuous supply of ink to a local ink reservoir over the course of a printing process.

Abstract: A cervical cell collection device, kit and method for the collection of cervical cells is provided. In some embodiments, the cervical cell collection device comprises an outer guide assembly having a distal end section with an aperture there through; an inner assembly positioned within the outer guide assembly, the inner assembly having a distal end with a collapsible collection pad secured thereto by a flexible collection support, wherein the inner assembly is movable from a first position where the collection pad is folded inside distal end section of the outer guide assembly to a second position where the collection pad is pushed through the aperture in the distal end of the outer guide assembly where it expands to contact and collect cervical cells.

Abstract: Integrated Multiplexed Point-of-Care device for measuring levels of target analytes from biological samples for determination of disease state. Specifically, a platform with a self contained fluidic cartridge comprising direct sample introduction, onboard sample processing, and multiplexed analyte detection is described.

Abstract: Optical readers and alignment tools for detecting the level of an analyte. Described herein are small, disposable partially-encapsulated sensing chips for detecting an analyte level from a fluid sample (e.g., a blood sample) having an edge of the integrated sensing chip exposed to directly expose a plurality of excitation and a collection waveguides, as well as optical readers and methods of operating them. A fluid sample maybe applied to a sensing surface of the sensing chip in the housing so that an analyte level can be optically detected. Also described are methods of sensing an analyte using these devices and systems including an optical detector.

Abstract: A disposable cuvette cartridge for optical measurements is formed from three flexible thin layers. The middle layer is an adhesive sheet with cut out regions, typically between 30 and 50, serving as optical chambers bounded by the two outer layers. Inlet and vent holes in one of the outer sheets provide access to the optical chambers. At least one of the outer sheets is made of a material having low fluorescence, such as a cyclo-olefin copolymer. With its low background fluorescence, the cuvette cartridge is useful for high-throughput fluorescence measurements of biological samples.

Abstract: Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes a translation stage joystick subsystem. The systems and methods provide the advantages of increased speed and much lower rates of contamination.

Abstract: A disposable cuvette cartridge for optical measurements is formed from three flexible thin layers. The middle layer is an adhesive sheet with cut out regions, typically between 30 and 50, serving as optical chambers bounded by the two outer layers. Inlet and vent holes in one of the outer sheets provide access to the optical chambers. At least one of the outer sheets is made of a material having low fluorescence, such as a cyclo-olefin copolymer. With its low background fluorescence, the cuvette cartridge is useful for high-throughput fluorescence measurements of biological samples.

Abstract: Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes a vacuum chuck subsystem that is adapted to hold a microscope slide down during the process of laser capture microdissection. The systems and methods provide the advantages of increased speed and much lower rates of contamination.

Abstract: Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes a vacuum chuck subsystem that is adapted to hold a microscope slide down during the process of laser capture microdissection. The systems and methods provide the advantages of increased speed and much lower rates of contamination.

Abstract: Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes an illumination/laser beam delivery system that is adapted to both illuminate a sample and provide energy for laser capture microdissection of the sample. The systems and methods provide the advantages of increased speed and much lower rates of contamination.

Abstract: Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes a vacuum chuck subsystem that is adapted to hold a microscope slide down during the process of laser capture microdissection. The systems and methods provide the advantages of increased speed and much lower rates of contamination.

Abstract: Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes a translation stage joystick subsystem. The systems and methods provide the advantages of increased speed and much lower rates of contamination.