Abstract: The present invention relates to the field of recombinant viral vectors suitable for the delivery of therapeutic genes in vivo. Described is an adeno-associated virus (AAV) vector comprising (i) a human growth hormone intron 3 (hGHi3) sequence (ii) a synapsin promoter sequence and/or (iii) a progranulin 3? untranslated region (UTR) sequence, operably coupled to a polynucleotide sequence encoding a polypeptide of interest. Specific use of such a vector lies in the enhanced expression of a polypeptide of interest, such as progranulin (PGRN), to treat subjects who have a genetic mutation or intrinsic polypeptide level that is below a physiologically normal level.

Abstract: A lithium borosilicate composition, consisting essentially of a system of lithium oxide in combination with silicon oxide and boron oxide, wherein said lithium borosilicate comprises between 70-83 atomic % lithium based on the combined atomic percentages of lithium, boron and silicon, and wherein said lithium borosilicate is a glass, is disclosed.

Abstract: A composite material for use as an electrode of an electrochemical cell comprises: a matrix that is provided by matrix particles that comprise an electrode active material; and a conductive fraction that is both electronically-conductive and ionically-conductive, the conductive fraction being provided by conductive particles that are distributed among the matrix particles. The conductive particles comprise either a material that is both ionically- and electronically-conductive; or a mixture of ionically-conductive particles and electronically-conductive particles, the electronically-conductive particles having a sphericity of at least 0.6. The conductive particles have a D90 value that is at least 10% of the D50 value of the matrix particles.

Abstract: A vapour deposition method for preparing an amorphous lithium-containing oxide or oxynitride compound not containing phosphorous comprises providing a vapour source of each component element of the compound, including at least a source of lithium, a source of oxygen, a source of nitrogen in the case of an oxynitride compound, and a source or sources of one or more glass-forming elements; heating a substrate to substantially 180° C. or above; and co-depositing the component elements from the vapour sources onto the heated substrate wherein the component elements react on the substrate to form the amorphous compound.

Abstract: A vapor deposition method for preparing a multi-layered thin film structure comprises providing a vapor source of each component element of a compound intended for a first layer and a compound intended for a second layer, wherein the vapor sources comprise at least a source of lithium, a source of oxygen, a source or sources of one or more glass-forming elements, and a source or sources of one or more transition metals; heating a substrate to a first temperature; co-depositing component elements from at least the vapor sources of lithium, oxygen and the one or more transition metals onto the heated substrate wherein the component elements react on the substrate to form a layer of a crystalline lithium-containing transition metal oxide compound; heating the substrate to a second temperature within a temperature range of substantially 170° C.

Abstract: A lithium borosilicate composition, consisting essentially of a system of lithium oxide in combination with silicon oxide and boron oxide, wherein said lithium borosilicate comprises between 70-83 atomic % lithium based on the combined atomic percentages of lithium, boron and silicon, and wherein said lithium borosilicate is a glass, is disclosed.

Abstract: The present invention provides a vapour deposition process for the preparation of a phosphate compound, wherein the process comprises providing each component element of the phosphate compound as a vapour, and co-depositing the component element vapours on a common substrate, wherein the component elements react on the substrate to form the phosphate compound.

Abstract: A vapour deposition method for preparing an amorphous lithium-containing oxide or oxynitride compound not containing phosphorous comprises providing a vapour source of each component element of the compound, including at least a source of lithium, a source of oxygen, a source of nitrogen in the case of an oxynitride compound, and a source or sources of one or more glass-forming elements; heating a substrate to substantially 180° C. or above; and co-depositing the component elements from the vapour sources onto the heated substrate wherein the component elements react on the substrate to form the amorphous compound.

Abstract: A vapour deposition method for preparing a crystalline lithium-containing transition metal oxide compound comprises providing a vapour source of each component element of the compound, including at least a source of lithium, a source of oxygen, and a source or sources of one or more transition metals; heating a substrate to between substantially 150° C. and substantially 450° C.; and co-depositing the component elements from the vapour sources onto the heated substrate wherein the component elements react on the substrate to form the crystalline compound.

Abstract: A vapour deposition method for preparing a multi-layered thin film structure comprises providing a vapour source of each component element of a compound intended for a first layer and a compound intended for a second layer, wherein the vapour sources comprise at least a source of lithium, a source of oxygen, a source or sources of one or more glass-forming elements, and a source or sources of one or more transition metals; heating a substrate to a first temperature; co-depositing component elements from at least the vapour sources of lithium, oxygen and the one or more transition metals onto the heated substrate wherein the component elements react on the substrate to form a layer of a crystalline lithium-containing transition metal oxide compound; heating the substrate to a second temperature within a temperature range of substantially 170° C.

Abstract: A main object of the present invention is to provide a Li—La—Ti—O based solid electrolyte material having high Li ion conductivity in the crystal grain boundary. The present invention attains the object by providing solid electrolyte material represented by a general formula: Li3x(La(2/3?x)?aM1a) (Ti1?bM2b)O3, wherein “x” is 0<x<0.17; “a” is 0?a?0.5; “b” is 0?b?0.5; “M1” is at least one selected from the group consisting of Sr, Na, Nd, Pr, Sm, Gd, Dy, Y, Eu, Tb, and Ba; and “M2” is at least one selected from the group consisting of Mg, W, Mn, Al, Ge, Ru, Nb, Ta, Co, Zr, Hf, Fe, Cr, and Ga, and wherein the solid electrolyte material is a crystalline material, is in thin film form, and has a thickness of 250 nm to 850 nm.

Abstract: A main object of the present invention is to provide a solid electrolyte material having excellent Li ion conductivity. To attain the object, the present invention provides a solid electrolyte material represented by a general formula: Lix(La2?aM1a)(Ti3?bM2b)O9+?, characterized in that “x” is 0<x?1; “a” is 0?a?2; “b” is 0?b?3; “?” is ?2???2; “M1” is at least one selected from the group consisting of Sr, Na, Nd, Pr, Sm, Gd, Dy, Y, Eu, Tb, and Ba; and “M2” is at least one selected from the group consisting of Mg, W, Mn, Al, Ge, Ru, Nb, Ta, Co, Zr, Hf, Fe, Cr, and Ga.

Abstract: A vapor deposition process for the preparation of a chemical compound, wherein the process comprises providing each component element of the chemical compound as a vapor, and co-depositing the component element vapors on a common substrate, wherein: the vapor of at least one component element is provided using a cracking source; the vapor of at least one other component element is provided using a plasma source; and at least one further component element vapor is provided; wherein the component elements react on the substrate to form the chemical compound.

Abstract: A main object of the present invention is to provide a solid electrolyte material having excellent Li ion conductivity. To attain the object, the present invention provides a solid electrolyte material represented by a general formula: Lix(La1-aM1a)y(Ti1-bM2b)zO?, characterized in that “x”, “y”, and “z” satisfy relations of x+y+z=1, 0.652?x/(x+y+z)?0.753, and 0.167?y/(y+z)?0.232; “a” is 0?a?1; “b” is 0?b?1; “?” is 0.8???1.2; “M1” is at least one selected from the group consisting of Sr, Na, Nd, Pr, Sm, Gd, Dy, Y, Eu, Tb, and Ba; and “M2” is at least one selected from the group consisting of Mg, W, Mn, Al, Ge, Ru, Nb, Ta, Co, Zr, Hf, Fe, Cr, and Ga.

Abstract: The present invention provides a vapour deposition process for the preparation of a phosphate compound, wherein the process comprises providing each component element of the phosphate compound as a vapour, and co-depositing the component element vapours on a common substrate, wherein the component elements react on the substrate to form the phosphate compound.

Abstract: A main object of the present invention is to provide a solid electrolyte material having excellent Li ion conductivity. To attain the object, the present invention provides a solid electrolyte material represented by a general formula: Lix(La1-aM1a)y(Ti1-bM2b)zO?, wherein “x”, “y”, and “z” satisfy relations of x+y+z=1, 0.850?x/(x+y+z)?0.930, and 0.087?y/(y+z)?0.115; “a” is 0?a?1; “b” is 0?b?1; “?” is 0.8???1.2; “M1” is at least one selected from the group consisting of Sr, Na, Nd, Pr, Sm, Gd, Dy, Y, Eu, Tb, and Ba; and “M2” is at least one selected from the group consisting of Mg, W, Mn, Al, Ge, Ru, Nb, Ta, Co, Zr, Hf, Fe, Cr, and Ga.

Abstract: A metal alloy catalyst for the oxygen reduction reaction in fuel cells is disclosed. The catalyst contains the metals Pd, M1 and M2. M1 and M2 are different metals selected from Co, Fe, Au, Cr and W, excluding the combination PdCoAu.

Abstract: The present invention provides a vapour deposition process for the preparation of a chemical compound, wherein the process comprises providing each component element of the chemical compound as a vapour, and co-depositing the component element vapours on a common substrate, wherein: the vapour of at least one component element is provided using a cracking source; the vapour of at least one other component element is provided using a plasma source; and at least one further component element vapour is provided; wherein the component elements react on the substrate to form the chemical compound.

Abstract: An object of the present invention is to provide a solid electrolyte membrane which comprises Li3xLa2/3-xTiO3 (0.05?x?0.17) and has excellent ion conductivity. Disclosed is a method for producing a solid electrolyte membrane which comprises a solid electrolyte described by the composition formula Li3xLa2/3-xTiO3 (0.05?x?0.17), the method comprising the steps of: producing a gas phase material comprising lithium, lanthanum and titanium by converting into a gas phase at least one selected from the group consisting of a lithium metal, a lanthanum metal, a titanium metal, a lithium-lanthanum alloy, a lithium-titanium alloy, a lanthanum-titanium alloy and a lithium-lanthanum-titanium alloy, and depositing an Li3xLa2/3-xTiO3 (0.05?x?0.17) thin film on a substrate by a gas phase method for reacting the gas phase material with oxygen in a single element state.

Abstract: A metal alloy catalyst for the oxygen reduction reaction in fuel cells is disclosed. The catalyst contains the metals Pd, M1 and M2. M1 and M2 are different metals selected from Co, Fe, Au, Cr and W, excluding the combination PdCoAu.