Patents by Inventor Christopher EGBULEFU

Christopher EGBULEFU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Near Infrared Fluorescent Dyes, Formulations and Related Methods
    Publication number: 20250001016
    Abstract: Provided herein is a pharmaceutical composition comprising an effective amount of cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Lys-OH (LS301), cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Tyr-OH (LS838) or pharmaceutically acceptable salts thereof, wherein each amino acid residue is independently in a D or L configuration; a divalent metal ion; and a pharmaceutically acceptable carrier. Further provided are lyophilized products comprising a dye-conjugate and m methods for identifying compromised and for binding phosphorylated annexin A2 (pANXA2) protein in a biological sample using a composition described herein.
    Type: Application
    Filed: September 16, 2024
    Publication date: January 2, 2025
    Applicant: Washington Univeristy
    Inventors: Samuel ACHILEFU, Rui TANG, Duanwen SHEN, Avik SOM, Baogang XU, Gail SUDLOW, Christopher EGBULEFU, Partha KARMAKAR, Kexian LIANG
  • Near infrared fluorescent dyes, formulations and related methods
    Patent number: 12121596
    Abstract: Provided herein is a pharmaceutical composition comprising an effective amount of cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Lys-OH (LS301), cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Tyr-OH (LS838) or pharmaceutically acceptable salts thereof, wherein each amino acid residue is independently in a D or L configuration; a divalent metal ion; and a pharmaceutically acceptable carrier. Further provided are lyophilized products comprising a dye-conjugate and m methods for identifying compromised and for binding phosphorylated annexin A2 (pANXA2) protein in a biological sample using a composition described herein.
    Type: Grant
    Filed: June 1, 2023
    Date of Patent: October 22, 2024
    Inventors: Samuel Achilefu, Rui Tang, Duanwen Shen, Avik Som, Baogang Xu, Gail Sudlow, Christopher Egbulefu, Partha Karmakar, Kexian Liang
  • NEAR INFRARED FLUORESCENT DYES, FORMULATIONS AND RELATED METHODS
    Publication number: 20230321283
    Abstract: Provided herein is a pharmaceutical composition comprising an effective amount of cypate-Cyclo (Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Lys-OH (LS301), cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Tyr-OH (LS838) or pharmaceutically acceptable salts thereof, wherein each amino acid residue is independently in a D or L configuration; a divalent metal ion; and a pharmaceutically acceptable carrier. Further provided are lyophilized products comprising a dye-conjugate and m methods for identifying compromised and for binding phosphorylated annexin A2 (pANXA2) protein in a biological sample using a composition described herein.
    Type: Application
    Filed: June 1, 2023
    Publication date: October 12, 2023
    Inventors: Samuel ACHILEFU, Rui TANG, Duanwen SHEN, Avik SOM, Baogang XU, Gail SUDLOW, Christopher EGBULEFU, Partha KARMAKAR, Kexian LIANG
  • Near infrared fluorescent dyes, formulations and related methods
    Patent number: 11712482
    Abstract: Provided herein is a pharmaceutical composition comprising an effective amount of cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Lys-OH (LS301), cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Tyr-OH (LS838) or pharmaceutically acceptable salts thereof, wherein each amino acid residue is independently in a D or L configuration; a divalent metal ion; and a pharmaceutically acceptable carrier. Further provided are lyophilized products comprising a dye-conjugate and m methods for identifying compromised and for binding phosphorylated annexin A2 (pANXA2) protein in a biological sample using a composition described herein.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: August 1, 2023
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Samuel Achilefu, Rui Tang, Duanwen Shen, Avik Som, Baogang Xu, Gail Sudlow, Christopher Egbulefu, Partha Karmakar, Kexian Liang
  • NEAR INFRARED FLUORESCENT DYES, FORMULATIONS AND RELATED METHODS
    Publication number: 20210177993
    Abstract: Provided herein is a pharmaceutical composition comprising an effective amount of cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Lys-OH (LS301), cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Tyr-OH (LS838) or pharmaceutically acceptable salts thereof, wherein each amino acid residue is independently in a D or L configuration; a divalent metal ion; and a pharmaceutically acceptable carrier. Further provided are lyophilized products comprising a dye-conjugate and m methods for identifying compromised and for binding phosphorylated annexin A2 (pANXA2) protein in a biological sample using a composition described herein.
    Type: Application
    Filed: December 11, 2020
    Publication date: June 17, 2021
    Inventors: Samuel ACHILEFU, Rui TANG, Duanwen SHEN, Avik SOM, Baogang XU, Gail SUDLOW, Christopher EGBULEFU, Partha KARMAKAR, Kexian LIANG