Abstract: A process for the solid phase synthesis of peptides containing an aza-amino acid, for example the decapeptide goserelin, which comprises:(i) assembling all the amino acids of the peptide except the C-terminal aza-amino acid by conventional solid phase synthesis;(ii) cleaving the peptide from the support with hydrazine or a substituted hydrazine; and(iii) reacting the hydrazide thus released with a cyanate ion.

Abstract: The invention relates to a polypeptide of formula I:R.sup.1 -A.sup.1 -A.sup.2 -A.sup.3 -A.sup.3 -A.sup.4 -A.sup.5 -A.sup.6 -A.sup.7 -A.sup.9 -Qwherein each of the generic terms is disclosed in full in the specification and includes: R.sup.1 is (2-6C)alkanoyl or (1-4C)alkoxycarbonyl; A.sup.1 is a direct link to A.sup.2, or is Gly or Arg; A.sup.2 is a direct link to A.sup.3, or is Gly or Pro; A.sup.3 is a direct link to A.sup.4, or is Lys or Lys(Z); A.sup.4 is His or D-His; A.sup.5 is Trp or MeTrp; A.sup.6 is Ala or MeAla; A.sup.7 is Val or MeVal; A.sup.8 is Gly or Sar; A.sup.9 is His or MeHis; and Q is a group of the formula -A.sup.10.R.sup.2 in which A.sup.10 is Leu or D-Leu and R.sup.2 is hydroxy, amino, (1-3C)alkylamino or (1-3C)alkoxy; or Q is (1-6C)alkoxy or (1-10C)alkylamino; provided that when R.sup.1 is acetyl and -A.sup.4 -A.sup.5 -A.sup.6 -A.sup.7 -A.sup.8 -A.sup.9 -Q is -His-Trp-Ala-Val-Gly-His-Leu-NH.sub.2 then -A.sup.1 -A.sup.2 -A.sup.3 - is not a direct link to His.

Abstract: The disclosure relates to novel polypeptides which possess analgesic activity, to processes for their manufacture and to pharmaceutical compositions containing them.

Abstract: This invention provides a method of enhancing, or preventing the decline in, the digestibility of a crop, in particular of a fodder crop, by applying to the crop, to seed of the crop, or to the locus of the crop or seed, a compound or a mixture of at least two compounds of general formula (I) ##STR1## wherein R is hydrogen or --COR.sup.1 wherein R.sup.1 is alkyl, aryl, aralkyl, alkoxy, aryloxy or aralkyloxy, X is --O--, --NE-- or --CH.sub.2 --, Y is carboxy or an alkali metal, ammonium or mono- or di-alkyl- or cycloalkylamine salt thereof, or Y is alkoxycarbonyl, aryloxycarbonyl, aralkyloxy- carbonyl, amino or mono- or di-alkyl- or aryl- amino, Z is hydrogen, halogen, nitro, alkyl, trihalomethyl, hydroxy, alkoxy, acyloxy, cyano or alkylenedioxy, and x is an integer of 1 to 3. The invention also provides novel compounds, namely L-.alpha.-aminooxy-.beta.-(parahydroxy phenyl) propionic acid, and acid addition salts thereof.

Abstract: The disclosure relates to novel polypeptides which possess analgesic and sedative activity, to processes for their manufacture and to compositions containing them. Typical of the peptides disclosed isH-Tyr-D-Ala-Gly-Phe-Leu-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-OH.