Patents by Inventor Christopher Fang-Yen

Christopher Fang-Yen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210084867
    Abstract: Systems and methods for automated imaging and manipulation of a plurality of small organisms are provided. In exemplary embodiments, the disclosed subject matter provides a housing, comprising an upper gantry, a lower gantry, and a tray with an array of plates, wherein the tray includes at least one source plate and at least one destination plate. The tray is adapted to hold the plurality of small organisms. A carriage, disposed within the upper gantry, is adapted to move relative to the tray. A camera, also disposed within the carriage, is adapted to acquire images of at least a portion of the small organisms. A computational processor, coupled to the camera, is adapted to identify an approximate size and shape for at least a portion of the small animals from the images, and to select one or more small animals based therefrom on its size and shape.
    Type: Application
    Filed: November 16, 2020
    Publication date: March 25, 2021
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Christopher FANG-YEN, Anthony FOUAD
  • Publication number: 20170107470
    Abstract: A composition, including a substrate having a planar array of depressions each defined by concave walls and a moat disposed around each depression of said array of depressions.
    Type: Application
    Filed: June 26, 2015
    Publication date: April 20, 2017
    Inventor: Christopher Fang-Yen
  • Patent number: 9546952
    Abstract: The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: January 17, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Wonshik Choi, Ramachandra Dasari, Christopher Fang-Yen, Michael Feld
  • Patent number: 9528817
    Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement of biological materials which can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: December 27, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Christopher Fang-Yen, Gabriel Popescu, Changhuei Yang, Adam Wax, Ramachandra Dasari, Michael Feld
  • Patent number: 9433351
    Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: September 6, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Chung-Chieh Yu, Condon Lau, Stephen Fulghum, Christopher Fang-yen, Ramachandra Dasari, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
  • Patent number: 8334982
    Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: December 18, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Christopher Fang-Yen, Gabriel Popescu, Changhuei Yang, Adam Wax, Ramachandra Dasari, Michael Feld
  • Publication number: 20120259228
    Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
    Type: Application
    Filed: May 4, 2012
    Publication date: October 11, 2012
    Inventors: Chung-Chieh Yu, Condon Lau, Stephen Fulghum, Christopher Fang-yen, Ramachandra Dasari, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
  • Publication number: 20070167835
    Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
    Type: Application
    Filed: July 25, 2006
    Publication date: July 19, 2007
    Inventors: Chung-Chieh Yu, Condon Lau, Stephen Fulghum, Christopher Fang-Yen, Ramachandra Dasari, Michael Feld
  • Publication number: 20050105097
    Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code.
    Type: Application
    Filed: June 18, 2004
    Publication date: May 19, 2005
    Applicant: Massachusetts Institute of Technology
    Inventors: Christopher Fang-Yen, Gabriel Popescu, Changhuei Yang, Adam Wax, Ramachandra Dasari, Michael Feld
  • Publication number: 20050057756
    Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code.
    Type: Application
    Filed: April 13, 2004
    Publication date: March 17, 2005
    Applicant: Massachusetts Institute of Technology
    Inventors: Christopher Fang-Yen, Gabriel Popescu, Changhuei Yang, Adam Wax, Ramachandra Dasari, Michael Feld