Abstract: Described herein are crystalline forms of (R)-3-(2-(trans-4-(2-aminoethylamino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid. In some embodiments, the crystalline forms are formulated for treating a subject in need thereof with a bacterial infection.

Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.

Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

Abstract: Methods and systems for networked computing systems is provided. One method includes generating by a processor, an application programming interface (API) template in a user preferred programming language to develop a plugin for a target system, the plugin customized for an application executed at the target system for providing a storage service associated with a storage object stored for the application; validating by the processor, an operation that the plugin has to perform for the storage service; uploading the plugin by the processor for deployment at the target system; and testing the deployed plugin by the processor at the target system. The plugin generation, validation, deployment and testing is executed using an integrated management system that provides the storage service.

Abstract: Methods for developing a decellularized tissue and biomaterials for use as biomimetic grafts or in vitro cellular scaffolds formed with the decellularized tissue are described. The biomaterials are particularly well suited for use as an intervertebral disc graft. The decellularized tissue is formed from an intervertebral disc source tissue and can be substantially decellularized and substantially free of potential immunogenic material (e.g., DNA and RNA), while maintaining ECM materials including both glycosaminoglycan and collagen.

Abstract: Methods for developing a decellularized tissue and biomaterials for use as biomimetic grafts or in vitro cellular scaffolds formed with the decellularized tissue are described. The biomaterials are particularly well suited for use as an intervertebral disc graft. The decellularized tissue is formed from an intervertebral disc source tissue and can be substantially decellularized and substantially free of potential immunogenic material (e.g., DNA and RNA), while maintaining ECM materials including both glycosaminoglycan and collagen.

Abstract: Methods for developing a decellularized tissue and biomaterials for use as biomimetic grafts or in vitro cellular scaffolds formed with the decellularized tissue are described. The biomaterials are particularly well suited for use as an intervertebral disc graft. The decellularized tissue is formed from an intervertebral disc source tissue and can be substantially decellularized and substantially free of potential immunogenic material (e.g., DNA and RNA), while maintaining ECM materials including both glycosaminoglycan and collagen.

Abstract: Embodiments of the system, and method provide for network support for providing caller flexibility on “name”, “number”, and “message” for a calling terminal that is displayed on a called terminal. One embodiment of the method may have the steps of: entering a command to use at least one of an alternate caller name, an alternate caller number and an alternate caller message for a calling terminal, instead of a preassigned caller name and caller number for the calling terminal; looking up the at least one of an alternate caller name, an alternate caller number and an alternate caller message; and using the at least one of an alternate caller name, an alternate caller number and an alternate caller message in place of the preassigned caller name and caller number for the calling terminal.

Abstract: A network component of an apparatus in one example employs one or more call characteristics to make a determination to initiate a request for one or more positions of one or more mobile stations.

Abstract: The present invention provides a method for establishing a multi-user call in a communication system. The communication system receives a call request to establish a group call with a shared group of users. The communication system determines which of the plurality of individual users should be excluded from the call and connects each of the group of included users to establish a multi-user call. The communication system preferably indicates that a unit was not currently available, for example by playing a prerecorded message, playing a tone and also preferably indicates why a unit was not available.

Abstract: The present invention provides a method for notifying a first user that a second user has returned to a call. A first user and a second user are engaged in a call on a communication path. The second user suspends the call, such as by placing the first user on hold. The communication system monitors that communication path to determine when the second user has activity on the communication path. The activity can comprise voice or data traffic. The communication system notifies the first user that the second user has returned to the call. The notification can occur by sending an audible signal to the first user, a visual indicator to the first user, a vibrating signal, or a paging signal to the first user. The call is then resumed.

Abstract: A method and apparatus for establishing connections among members of telecommunications connections among members of a group of users. The group is identified in a setup request and a database is used to translate between the identity of the group and the identity of the members of the group. Connections are then established between a media duplicator and the individual members of the group. The media duplicator receives signals from all members of the group, combines them according to an appropriate algorithm, and transmits the combined signal to all members of the group. Advantageously, this arrangement allows frequently used group conferences to be established with a minimum of effort by the conferees.

Abstract: A telecommunications system for providing an initial caller with access to one of a plurality of conversations each relating to a particular conversation topic available in the system. The system includes a voice recognizer and response unit for communicating with the caller. The caller selects a desired conversation topic by either generating an audio command to the voice recognizer, inputting a command in the keypad of the caller's telephone or computer, or communicating with a human operator. Upon selection of an available topic, the system connects the caller to a current conversation relating to that topic. In the event that there are no current conversations for the selected topic, the call is terminated and the system automatically calls back the initial caller when another caller selects the same topic as the initial caller.