Abstract: A computer-implemented method is provided for detecting actionable transaction risks. The method includes grouping an inbound event related to a transaction with a target event group and determining an actionable group of events that are deemed high risk and a non-actionable group of non-actionable events that are deemed low risk. The method also includes evaluating the target event group relative to the actionable and non-actionable groups of events. This includes computing a first distance between the target event group and the non-actionable group and a second distance between the target event group and actionable group. The first distance is compared with the second distance to determine if the target event group, including the inbound event, is closer to the actionable group or to the nonactionable group.

Abstract: A thermoplastic vascular structure has a first thermoplastic sheet including at least one first recess; and a second thermoplastic sheet. The first thermoplastic sheet is attached to the second thermoplastic sheet to create a continuous branched vascular network structure. The at least one first recess creates at least one fluid channel through the continuous branched vascular network structure. The second thermoplastic sheet may have at least one second recess. The at least one first recess of the first thermoplastic sheet may align with the at least one second recess of the second thermoplastic sheet to create the at least one fluid channel through the continuous branched vascular network structure.

Abstract: Embodiments of the present invention disclose a suction stylet assembly for endotracheal intubation. The assembly includes an elongated tubular member, the elongated tubular member having one or more apertures proximate to a first end, and a handle in communication with a second end of the elongated tubular member. The handle member includes a first passageway connecting the elongated tubular member to a hose fitting on the handle member, the hose fitting configured to receive a hose that provides suction in removing bodily fluids. The handle member further includes an aperture located on a side of the handle member, the aperture forming a second passageway through the handle member running between the side and the first passageway, the aperture configured to permit a user to selectively block the aperture, thereby selectively controlling suction provided between the hose fitting and the elongated tubular member.

Abstract: An inhaler device (1) contains, or is capable of accepting, a plurality of doses of a medicament to be dispensed from the inhaler (1). To ameliorate the problem of double dosing from the inhaler (1), the device further comprises prevention means (26, 28, 40) for preventing, at least temporarily, the dispensing of a dose of medicament, and detection means (32) for detecting the inhalation of a previously dispensed dose of medicament. When the detection means (32) detects the inhalation of the previously dispensed dose of medicament, it releases the prevention means (26, 28, 40), allowing the device to dispense a further dose of medicament. The detection means (32) may be a pressure sensor, and the prevention means (26, 28, 40) may operate by causing a disengagement of an actuation mechanism.

Abstract: A compliance monitor (20) is attachable to or forms part of a drug delivery device, such as an inhaler (2). The monitor comprises a flexible portion (38) to enable a switch which is actuated by a user when delivering a dose of medicament. The monitor further comprises a sensor for sensing whether the device is properly positioned in contact with or relative to the user's body for administration of the medicament. For example, where the device is an inhaler and the sensor a temperature sensor, temperature variations caused by insertion of an inhaler mouthpiece into the user's mouth indicate whether the dose has been delivered into the patient's mouth. A memory in the compliance monitor stores a compliance record indicating whether or not the device was properly positioned each time a dose was delivered.

Abstract: An inhaler device (1) contains, or is capable of accepting, a plurality of doses of a medicament to be dispensed from the inhaler (1). To ameliorate the problem of double dosing from the inhaler (1), the device further comprises prevention means (26, 28, 40) for preventing, at least temporarily, the dispensing of a dose of medicament, and detection means (32) for detecting the inhalation of a previously dispensed dose of medicament. When the detection means (32) detects the inhalation of the previously dispensed dose of medicament, it releases the prevention means (26, 28, 40), allowing the device to dispense a further dose of medicament. The detection means (32) may be a pressure sensor, and the prevention means (26, 28, 40) may operate by causing a disengagement of an actuation mechanism.

Abstract: A compliance monitor (20) is attachable to or forms part of a drug delivery device, such as an inhaler (2). The monitor comprises a flexible portion (38) to enable a switch which is actuated by a user when delivering a dose of medicament. The monitor further comprises a sensor for sensing whether the device is properly positioned in contact with or relative to the user's body for administration of the medicament. For example, where the device is an inhaler and the sensor a temperature sensor, temperature variations caused by insertion of an inhaler mouthpiece into the user's mouth indicate whether the dose has been delivered into the patient's mouth. A memory in the compliance monitor stores a compliance record indicating whether or not the device was properly positioned each time a dose was delivered.

Abstract: Many of the effects of nitric oxide are mediated by the direct modification of cysteine residues resulting in an adduct called a nitrosothiol. A method to detect proteins which contain nitrosothiols involves several steps. Nitrosylated cysteines are converted to tagged cysteines. Tagged proteins can then be detected, for example, by immunoblotting and/or can be purified by affinity chromatography. The method is applicable to the detection of S-nitrosylated proteins in cell lysates following in vitro S-nitrosylation, as well as to the detection of endogenous S-nitrosothiols in selected protein substrates.

Abstract: Disclosed are methods for preventing or treating a gastrointestinal (GI) disorder in a mammal such as a human patient. In one embodiment, the methods include administering to the mammal a therapeutically effective amount of a compound that modulates a nitric oxide (NO) signaling pathway, particularly in GI neurons. Methods of the invention are particularly useful for the treatment (including prophylactic treatment) of diabetic gastropathies and other GI disorders.