Abstract: A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat at least one of non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).

Abstract: Provided herein are systems for treating tissue of a patient. The system comprises an energy delivery console and at least one energy delivery device. The energy delivery console can provide a first dose of energy and a second dose of energy. An energy delivery device comprises a first delivery element configured to deliver the first dose of energy to target tissue, and a second delivery element configured to deliver the second dose of energy to the target tissue. The first dose of energy can comprise a delivery of energy that reversibly alters the target tissue, and the second dose of energy can comprise a delivery of energy that irreversibly alters the target tissue. The first dose of energy can be delivered to enhance a therapy provided by the second dose of energy.

Abstract: Methods of generating a graphical representation of cardiac information on a display screen are provided. The method comprises: electronically creating or acquiring an anatomical model of the heart including multiple cardiac locations; electronically determining a data set of source information corresponding to cardiac activity at the multiple cardiac locations; electronically rendering the data set of source information in relation to the multiple cardiac locations on the display screen. Systems and devices for providing a graphical representation of cardiac information are also provided.

Abstract: A medical apparatus for the treatment of one or more sleep disorders such as obstructive sleep apnea in a patient is provided. The apparatus has an elongate member with a middle portion, a first fixation element and a second fixation element. The middle portion applies a force to a segment of a patient's airway.

Abstract: A system for delivering an agent to a patient, comprises a delivery device. The delivery device is configured to deliver a first agent to the patient, and comprises a reservoir, a transcutaneous delivery assembly, a pumping mechanism, a control module, a power supply, and a housing. The reservoir stores the first agent. The transcutaneous delivery assembly delivers the first agent to the patient transcutaneously. The pumping mechanism receives the first agent from the reservoir and propels the first agent to the transcutaneous delivery assembly. The control module controls at least the pumping mechanism. The power supply provides energy to at least the control module and the pumping mechanism. The housing surrounds at least the pumping mechanism. Methods of delivering an agent to the patient are also described.

Abstract: A medical appliance for the treatment of one or more sleep disorders such as obstructive sleep apnea in a patient, the appliance comprising: a biasing member for inserting behind and exerting a force upon the patient's soft palate or tongue, wherein the biasing member is inserted in a reduced or minimized form and then expanded or firms once in place to exert the force. The appliance may be nasally inserted or be placed through the mouth. In a particular configuration, both the soft palate and tongue are biased to prevent obstruction of the flow of air in the nasopharyngeal airway.

Abstract: A device for expanding tissue comprises at least one fluid delivery tube and at least one fluid delivery element in fluid communication with the at least one fluid delivery tube. The at least one fluid delivery tube comprises a proximal end, a distal end, and a lumen therebetween. The device is constructed and arranged to perform a near full circumferential expansion of luminal wall tissue. Systems and methods are also provided, including a system for expanding tissue layers and treating tissue proximate to the expanded tissue layers.

Abstract: Methods, systems and devices for treating a patient include performing a first treatment to treat a first portion of tissue and performing a second treatment to treat a second portion of tissue. The second portion of tissue is treated at least twenty-four hours after the first portion of tissue is treated. In particular embodiments, the first portion of tissue includes duodenal tissue, and the second portion of tissue includes duodenal or other gastrointestinal tissue.

Abstract: Sleep systems and devices including a mattress conversion device and a mattress are disclosed. The mattress conversion device includes a base layer, one or more side portions, and a cavity defined by the base layer and the one or more side portions. The mattress conversion device can slidingly received the mattress. A method for recycling an existing mattress is also disclosed.

Abstract: Systems, devices, and methods for treating a nerve injury in a patient are provided herein. The system includes an extracellular matrix, a neutralizing element, and a reconstituting element. The extracellular matrix is configured to promote and/or sustain the growth of tissue and/or associated tissue properties proximate the nerve injury.

Abstract: An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.

Abstract: A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

Abstract: Provided herein are systems for stimulating cardiac tissue of a patient. The systems include: a pulse generator having a first transmission element for delivering wireless power; a stimulation assembly having a flexible substrate, a second transmission element for receiving the wireless power from the first transmission element of the pulse generator, one or more electrodes attached to the substrate for delivering electrical energy to cardiac tissue, and one or more microcircuits attached to the substrate for delivering electrical energy to the one or more electrodes; and an algorithm having a fibrillation detection algorithm for determining when the one or more electrodes deliver the energy to the cardiac tissue.

Abstract: Provided herein are systems for treating a patient, the systems comprising: a treatment device for treating a minimum amount of mucosal tissue of the patient's small intestine. The system is configured to treat a medical condition of the patient. Methods of treating a patient are also provided.

Abstract: A system for treatment target tissue comprises an ablation device and an energy delivery unit. The ablation device comprises an elongate tube with an expandable treatment element. The system delivers a thermal dose of energy to treat the target tissue. Methods of treating target tissue are also provided.

Abstract: A temperature measurement probe for a patient is provided. The probe includes a sensor assembly and produces a temperature map comprising temperature information for multiple patient locations.

Abstract: An imaging system for a patient comprises an imaging probe. The imaging probe comprises: an elongate shaft for insertion into the patient and comprising a proximal end, a distal portion, and a lumen extending between the proximal end and the distal portion; a rotatable optical core comprising a proximal end and a distal end, the rotatable optical core configured to optically and mechanically connect with an interface unit; a probe connector positioned on the elongate shaft proximal end and surrounding at least a portion of the rotatable optical core and an optical assembly positioned in the elongate shaft distal portion and proximate the rotatable optical core distal end, the optical assembly configured to direct light to tissue and collect reflected light from the tissue. A shear-thinning fluid can be provided between the elongate shaft and the rotatable optical core, such as to reduce undesired rotational variations of the rotatable optical core.

Abstract: A stimulation apparatus for a patient is provided, the apparatus comprising an external system configured to transmit transmission signals and an implantable system configured to receive the transmission signals from the external system. The implantable system comprises at least one implantable lead, a first implantable device for connecting to the implantable lead during a first time period and a second implantable device for subsequently connecting to the implantable lead for a second time period.

Abstract: A patient diagnostic system comprises at least one implantable device configured to record one or more patient physiologic parameters. The at least one implantable device comprising one or more of each of the following implantable sensors: an accelerometer; a pressure sensor; a temperature sensor; an acoustic sensor; and a pair of electrodes. At least one external device configured to produce data can also be included in the system.

Abstract: A medical appliance for the treatment of obstructive sleep apnea in a patient, the appliance comprising: a securing device configured to be removably affixed to the patient's jaw; and a biasing member which is insertable behind the soft palate and/or the base of the patient's tongue, thereby providing for the flow of air in the nasopharyngeal airway; wherein the securing device is connected to the biasing member to allow insertion and/or removal of the biasing member from the nasopharyngeal airway.