Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: A mechanical valve assembly for the control of a gas flow to a gas appliance. The mechanical valve assembly includes at least one input knob movably connected to a housing, a shaft assembly connected to at least one input knob, and a manually-operated valve located inside the housing and in between the inlet port and the outlet port. The manually-operated valve is mechanically connected to the shaft assembly, and the manually-operated valve is configured for opening and closing a gas flow between the inlet port and the outlet port.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: Techniques are disclosed for coding and delivering multi-view video in which the video is represented as a manifest file identifying a plurality of segments of the video available for download. The multi-view video may be partitioned spatially into a plurality of tiles that, in aggregate, encompass the entire spatial area of the video. The tiles are coded as segments contains coded video representing content contained within its respective tile. Tiles may be given different sizes based on saliency of the content within their respective regions. In this manner, tiles with high levels of interest may have relatively large spatial areas, which can lead to efficient coding in the presence of content motion.

Abstract: Techniques are disclosed for coding and delivering multi-view video in which the video is represented as a manifest file identifying a plurality of segments of the video available for download. The multi-view video may be partitioned spatially into a plurality of tiles that, in aggregate, encompass the entire spatial area of the video. The tiles are coded as segments contains coded video representing content contained within its respective tile. Tiles may be given different sizes based on saliency of the content within their respective regions. In this manner, tiles with high levels of interest may have relatively large spatial areas, which can lead to efficient coding in the presence of content motion.

Abstract: Embodiments of the present disclosure provide techniques for rendering content from a media item. According to these embodiments, from a file of the media item, track(s) in a group data structure corresponding to the type of content are identified as candidate track(s). From other tracks in the file, a determination may be made whether another track corresponds to the type of content. When another track corresponds to the type of content, feature tags in the file that are associated may be compared with the other track to capabilities of a player device that is to render the type of content. When the feature tags match capabilities of the player device, the other track may be included as a candidate track. Thereafter, a track may be selected from the candidate tracks and rendered by the player device.

Abstract: A mechanical valve assembly for the control of a gas flow to a gas appliance. The mechanical valve assembly includes at least one input knob movably connected to a housing, a shaft assembly connected to at least one input knob, and a manually-operated valve located inside the housing and in between the inlet port and the outlet port. The manually-operated valve is mechanically connected to the shaft assembly, and the manually-operated valve is configured for opening and closing a gas flow between the inlet port and the outlet port.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: The present invention provides compounds, pharmaceutical compositions, methods of inhibiting ROR? activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.

Abstract: A mechanical valve assembly for the control of a gas flow to a gas appliance, the mechanical valve assembly comprising: a housing; a gas inlet port associated with the housing; a gas outlet port associated with the housing; a timer-controlled valve operable to open and close a gas flow between the inlet port and outlet port; and a manually-operated emergency shut-off valve positioned between the inlet port and the outlet port, ahead of the timer-controlled valve relative to a direction of the gas flow through the mechanical valve assembly.

Abstract: The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating ROR? activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.

Abstract: The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating ROR? activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.

Abstract: Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: The present invention provides sulfonamide-substituted indoles and Methods of Use Thereof-substituted pyrrolopyridines, pharmaceutical compositions thereof methods of modulating RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such indoles and pharmaceutical compositions thereof.

Abstract: The present invention provides methoxy-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating ROR? activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.

Abstract: Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating ROR? activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.

Abstract: The present invention provides compounds, pharmaceutical compositions, methods of inhibiting ROR? activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.