Abstract: The present disclosure provides a feedback mechanism for a medicament delivery device, the feedback mechanism includes (i) a housing structure including a holding arm, (ii) a plunger rod configured to engage with the holding arm in a pre-tensioned state, and (iii) a signal generating member attached to the housing structure, the signal generating member including a resilient tongue which in the pre-tensioned state of the plunger rod is arranged in contact with a first portion of the plunger rod. The plunger rod includes a second portion arranged distally from the first portion, the second portion including a cut-out. The resilient tongue is operably arranged to, upon movement of the plunger rod in the proximal direction, be brought into contact with the second portion of the plunger rod to interact with the cut-out for generating an audible and/or tactile feedback.

Abstract: A The present disclosure provides a sub-assembly for a medicament delivery device configured to expel medicament from a medicament container. The sub-assembly includes a housing, a pre-tensioned plunger rod, a holding sleeve fixedly attached to the housing, the holding sleeve comprising at least one holding arm arranged to lock the plunger rod in its pre-tensioned state, and a rear cap having a blocking surface arranged to prevent the holding arm from releasing the plunger rod from its pre-tensioned state.

Abstract: An agricultural vehicle including a control system to control slip of a tractive element. The control system includes processing circuitry configured to obtain an indication of a priority operating parameter from a plurality of operating parameters of the agricultural vehicle. The control system is configured to perform an adjustment to at least one non-priority operating parameter from the plurality of operating parameters of the agricultural vehicle when a first slip value of the tractive element exceeds a threshold. The control system configured to operate the agricultural vehicle according to the adjustment to the at least one non-priority operating parameter. The control system configured to perform an adjustment to the priority operating parameter upon a second slip value of the tractive element exceeding the threshold. The control system configured to operate the agricultural vehicle according to the adjustment to the priority operating parameter.

Abstract: The present disclosure provides an inner tubular body for a medicament delivery device. The inner tubular body extends along a longitudinal axis from a proximal end to a distal end. The inner tubular body includes a distal part and a proximal part. The distal part includes a flexible arm extending distally, the flexible arm comprises a first spring support at the distal end of the flexible arm and a plunger rod support at the distal end of the flexible arm. The first spring support is inclined in a radially inward direction and is configured to support a distal end of a drive spring of the medicament delivery device when the medicament delivery device is in a non-activated state. The distal part further includes a second spring support extending distally and being configured to support the distal end of the drive spring of the medicament delivery device when the medicament delivery device is in an activated state.

Abstract: A location control subsystem is provided that allows a user of an electronic device to define the granularity used to provide location coarseness. A user can define a coarse location granularity for an application. When a coarse device location is reported to an application, the location can be provided with at least a minimum degree of variable specificity based on the selected location coarseness. When an application is granted a coarse location, the application is to interpret the provided location indicating that the user may be anywhere within a geographic region of variable specificity, as opposed to being close to a center point with a horizontal accuracy based on the precision of the location fix, as when a fine granularity location is provided. In addition to reducing the spatial resolution of the location that is reported to the application, the temporal resolution may also be reduced.

Abstract: A modular capacitive sensing switch provides a separate circuit module attachable to a variety of electrode modules, the latter having different configurations. Embodiments providing adhesive mounting and network connections allow simple configuration of a wide variety of capacitive touch panel systems.

Abstract: A modular capacitive sensing switch provides a separate circuit module attachable to a variety of electrode modules, the latter having different configurations. Embodiments providing adhesive mounting and network connections allow simple configuration of a wide variety of capacitive touch panel systems.

Abstract: A surgical retractor for retracting tissue in a surgical field in a patient includes a retractor blade formed from a material so that the retractor blade is non-magnetic, electrically non-conductive, radiolucent, sterilizable and reusable. The material may be a glass filled polymer. A handle may be coupled to a proximal portion of the retractor blade. Additionally an illumination element such as an optical waveguide or light emitting diodes may be coupled to the retractor blade for illuminating the surgical field.

Abstract: A control system and method is provided to control the trajectory of a transport vehicle (20) to follow the trajectory of a harvester (10). The harvester can send control information such as the harvester's current position and future position waypoints to the transport vehicle. The control system can then use the information from the harvester to determine the trajectory for the transport vehicle.

Abstract: Systems and methods are described herein for detecting particles emitted by nuclear material. The systems comprise one or more semiconductor devices for detecting particles emitted from nuclear material. The semiconductor devices can comprise a charge storage element comprising several layers. A non-conductive charge storage layer enveloped on top and bottom by dielectric layers is mounted on a substrate. At least one top semiconductor layer can be placed on top of the top dielectric layer. A reactive material that reacts to particles, such as neutrons emitted from nuclear material, can be incorporated into the top semiconductor layer. When the reactive material reacts to a particle emitted from nuclear material, ions are generated that can alter the charge storage layer and enable detection of the particle.

Abstract: A control system and method is provided to control the trajectory of a transport vehicle (20) to follow the trajectory of a harvester (10). The harvester can send control information such as the harvester's current position and future position waypoints to the transport vehicle. The control system can then use the information from the harvester to determine the trajectory for the transport vehicle.

Abstract: A method includes forming a layer of silicon oxynitride (SiON), silicon rich nitride (SiRN) or silicon nitride (Si3N4) over a layer of semiconducting material. The method further includes forming a first layer of anti-reflective material over the layer of SiON, SiRN or Si3N4 and forming a second layer of anti-reflective material over the first layer. The method also includes using the first layer, second layer and layer of SiON, SiRN or Si3N4 as a mask when etching a pattern in the layer of semiconducting material.

Abstract: Methods and compositions are provided for modulating, e.g., increasing or decreasing, the expression of telomerase reverse transcriptase (TERT). In the subject methods, the binding interaction of the TERT Site C repressor site with a Site C repressor protein complex made up of one or more proteins is modulated to achieve the desired change in TERT expression. A feature of the subject invention is that the target Site C repressor protein complex includes an LSF protein. The subject methods and compositions find use in a variety of different applications, including the immortalization of cells, the production of reagents for use in life science research, therapeutic applications; therapeutic agent screening applications; and the like.

Abstract: Nucleic acid compositions comprising a region and a TERT minimal promoter activator binding site that acts to activate transcription of the telomerase reverse transcriptase (TERT) coding sequence, as well as vectors and constructs including the same, are provided. Also provided are methods of modulating, e.g., inhibiting, the TERT transcription activation activity of the subject TERT activator binding site regions in order to regulate, e.g., repress, telomerase expression, which methods find use in a variety of different applications, including the therapeutic applications and the like. In addition, methods of screening for agents that modulate the TERT transcription activating activity of the subject TERT activator sites are provided. The subject invention finds use in, among other applications, the regulation of TERT expression.

Abstract: Methods and compositions are provided for modulating, and generally upregulating, the expression of telomerase reverse transcriptase (TERT) by blocking repression of TERT transcription, e.g., by inhibiting binding of repressor factor to a Site C repressor binding site located in the TERT minimal promoter. The subject methods and compositions find use in a variety of different applications, including the immortalization of cells, the production of reagents for use in life science research, therapeutic applications; therapeutic agent screening applications; and the like. In further describing the subject invention, the methods and compositions of the invention are described first in greater detail, followed by a review of the various applications in which the subject invention finds use.

Abstract: Telomerase repressor proteins and nucleic acid compositions encoding the same are provided. The subject repressor proteins bind to a repressor site in the TERT minimal promoter, e.g., a Site C site, and thereby inhibit TERT expression. Also provided are methods of modulating, e.g., inhibiting or enhancing, TERT expression. The subject invention finds use in a variety of different applications, including therapeutic and therapeutic agent screening applications.

Abstract: Nucleic acid compositions comprising an Ikaros or WT1 repressor binding site that act to repress transcription of the telomerase reverse transcriptase (TERT) coding sequence, as well as vectors and constructs including the same, are provided. Also provided are methods of modulating, e.g., inhibiting, the TERT transcription repressing activity of the subject WT1 and Ikaros repressor binding site regions in order to regulate, e.g., enhance, telomerase expression, which methods find use in a variety of different applications, including the production of reagents for use in life science research, therapeutic applications and the like. In addition, methods of screening for agents that modulate the TERT transcription repressing activity of the subject WT1 and Ikaros sites are provided. The subject invention finds use in, among other applications, the regulation of TERT expression.

Abstract: A method includes forming a layer of silicon oxynitride (SiON), silicon rich nitride (SiRN) or silicon nitride (Si3N4) over a layer of semiconducting material. The method further includes forming a first layer of anti-reflective material over the layer of SiON, SiRN or Si3N4 and forming a second layer of anti-reflective material over the first layer. The method also includes using the first layer, second layer and layer of SiON, SiRN or Si3N4 as a mask when etching a pattern in the layer of semiconducting material.

Abstract: The apparatus is an automatic velocity control system for an agricultural machine. Three feedback circuits are used to increase reliability and repeatability of the apparatus despite variations in load and ground conditions and non-linear responses of control components. A solenoid current sensor supplies a feedback signal to control a current controller for solenoids controlling a hydraulic valve, a hydraulic cylinder position sensor provides a feedback signal to counteract the non-linearity of the hydraulic valve controlling the hydraulic cylinder, and wheel speed sensors supply vehicle speed signals to be compared to the signal from the operator's speed control. A microprocessor processes the sensor signals to maintain the desired velocity.

Abstract: A method is disclosed for the definition of the poly-1 layer in a semiconductor wafer. A non-critical mask is used to recess field oxides in the periphery prior to poly-1 deposition by an amount equal to the final poly-1 thickness. A complimentary non-critical mask is used to permit CMP of the core to expose the tops of core oxide mesas from the shallow isolation trenches.