Patents by Inventor Christopher Fotsch

Christopher Fotsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8791147
    Abstract: The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula (I). Where Cy1 is pyridinonyl, pyridinyl, quinolinyl or 9-ethyl-9H-beta-carbolinyl, each of which optionally substituted and where Cy2 is phenyl naphthyl.
    Type: Grant
    Filed: October 7, 2009
    Date of Patent: July 29, 2014
    Assignee: Amgen Inc.
    Inventors: Christopher Fotsch, Paul Harrington
  • Patent number: 8324396
    Abstract: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: December 4, 2012
    Assignee: Amgen Inc.
    Inventors: Pierre Deprez, Christopher Fotsch, Paul Harrington, Sarah Lively, Kanaka Pattabiraman, David St. Jean, Taoues Temal-Laib
  • Publication number: 20110230517
    Abstract: The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula (I). Where Cy1 is pyridinonyl, pyridinyl, quinolinyl or 9-ethyl-9H-beta-carbolinyl, each of which optionally substituted and where Cy2 is phenyl naphthyl.
    Type: Application
    Filed: October 7, 2009
    Publication date: September 22, 2011
    Inventors: Christopher Fotsch, Paul Harrington
  • Publication number: 20090054463
    Abstract: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.
    Type: Application
    Filed: July 10, 2008
    Publication date: February 26, 2009
    Inventors: Pierre Deprez, Christopher Fotsch, Paul Harrington, Sarah Lively, Kanaka Pattabiraman, David St. Jean, Taoues Temal-Laib
  • Publication number: 20080045503
    Abstract: The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-?-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-?-hydroxysteroid dehydrogenase type 1 enzyme.
    Type: Application
    Filed: June 28, 2007
    Publication date: February 21, 2008
    Inventors: Martin Henriksson, Evert Homan, Lars Johansson, Jerk Vallgarda, Meredith Williams, Eric Bercot, Christopher Fotsch, Aiwen Li, Guolin Cai, Randall Hungate, Chester Yuan, Christopher Tegley, David St. Jean, Nianhe Han, Qi Huang, Qingyian Liu, Michael Bartberger, George Moniz, Matthew Frizzle
  • Publication number: 20080021022
    Abstract: Compounds of formula I and IV are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorder: wherein the variables A-B, R1, R2, m, and Q are described herein.
    Type: Application
    Filed: July 18, 2007
    Publication date: January 24, 2008
    Inventors: Michael Bartberger, Christopher Fotsch, Martin Haraldsson, David St. Jean, Lars Johansson, Marianne Nilsson, Lori Sutin, Katrina Flyren
  • Publication number: 20070265248
    Abstract: Selected substituted piperazine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Application
    Filed: April 27, 2005
    Publication date: November 15, 2007
    Applicant: Amgen Inc.
    Inventors: Christopher Fotsch, Premilla Arasasingham, Yunxin Bo, Ning Chen, Martin Goldberg, Nianhe Han, Feng-Yin Hsieh, Michael Kelly, Qingyian Liu, Mark Norman, Duncan Smith, Markian Stec, Nuria Tamayo, Ning Xi, Shimin Xu, Elizabeth Doherty
  • Publication number: 20070197598
    Abstract: The present invention relates to thiazolinones and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-?-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-?-hydroxysteroid dehydrogenase type 1 enzyme.
    Type: Application
    Filed: November 13, 2006
    Publication date: August 23, 2007
    Inventors: Martin Henriksson, Evert Homan, Lars Johansson, Jerk Vallgarda, Meredith Williams, Eric Bercot, Christopher Fotsch, Aiwen Li, Guolin Cai, Randall Hungate, Chester Yuan, Christopher Tegley, David Jean, Nianhe Han, Qi Huang, Qingyian Liu, Michael Bartberger, George Moniz, Matthew Frizzle, Teresa Marshall
  • Publication number: 20070173506
    Abstract: The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
    Type: Application
    Filed: January 11, 2007
    Publication date: July 26, 2007
    Applicant: AMGEN INC.
    Inventors: Qingping Zeng, John Allen, Matthew Bourbeau, Celia Dominguez, Christopher Fotsch, Nianhe Han, Fang-Tsao Hong, Xin Huang, Matthew Lee, Aiwen Li, Qingyian Liu, James Rider, Seifu Tadesse, Andrew Tasker, Vellarkad Viswanadhan, Xianghong Wang, Kurt Weiler, George Wohlhieter, Guomin Yao, Chester Yuan
  • Publication number: 20060142357
    Abstract: The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-?-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-?-hydroxysteroid dehydrogenase type 1 enzyme.
    Type: Application
    Filed: May 24, 2005
    Publication date: June 29, 2006
    Inventors: Martin Henriksson, Evert Homan, Lars Johansson, Jerk Vallgarda, Meredith Williams, Eric Bercot, Christopher Fotsch, Aiwen Li, Guolin Cai, Randall Hungate, Chester Yuan, Christopher Tegley, David Jean, Nianhe Han, Qi Huang, Qingyian Liu, Michael Bartberger, George Moniz, Matthew Frizzle
  • Publication number: 20060030618
    Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, d
    Type: Application
    Filed: April 5, 2005
    Publication date: February 9, 2006
    Inventors: Yunxin Bo, Partha Chakrabarti, Ning Chen, Elizabeth Doherty, Christopher Fotsch, Nianhe Han, Michael Kelly, Qingyian Liu, Mark Norman, Vassil Ognyanov, Xianghong Wang, Jiawang Zhu
  • Publication number: 20050277631
    Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, d
    Type: Application
    Filed: August 1, 2005
    Publication date: December 15, 2005
    Inventors: Elizabeth Doherty, Jiawang Zhu, Markian Stec, Mark Norman, Hui-Ling Wang, Christopher Fotsch, Ning Chen, Partha Chakrabarti, Celia Dominguez, James Falsey, Christopher Hulme, Jodie Katon, Thomas Nixey, Vassil Ognyanov, Liping Pettus, Robert Rzasa
  • Publication number: 20050277646
    Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, d
    Type: Application
    Filed: August 1, 2005
    Publication date: December 15, 2005
    Inventors: Elizabeth Doherty, Jiawang Zhu, Markian Stec, Mark Norman, Vassil Ognyanov, Christopher Fotsch, Ning Chen, Partha Chakrabarti, Liping Pettus, Hui-Ling Wang, Xianghong Wang, Premilla Arasasingham
  • Publication number: 20050272931
    Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, d
    Type: Application
    Filed: April 5, 2005
    Publication date: December 8, 2005
    Inventors: Yunxin Bo, Partha Chakrabarti, Ning Chen, Elizabeth Doherty, Christopher Fotsch, Nianhe Han, Michael Kelly, Qingyian Liu, Mark Norman, Vassil Ognyanov, Xianghong Wang, Jiawang Zhu
  • Publication number: 20050272777
    Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, d
    Type: Application
    Filed: August 1, 2005
    Publication date: December 8, 2005
    Inventors: Elizabeth Doherty, Jiawang Zhu, Markian Stec, Mark Norman, Hui-Ling Wang, Christopher Fotsch, Ning Chen, Partha Chakrabarti, Celia Dominguez, James Falsey, Christopher Hulme, Jodie Katon, Thomas Nixey, Vassil Ognyanov, Liping Pettus, Robert Rzasa
  • Publication number: 20050234044
    Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Application
    Filed: April 13, 2004
    Publication date: October 20, 2005
    Inventors: Robert Groneberg, James Zhan, Benny Askew, Derin D'Amico, Nianhe Han, Christopher Fotsch, Qingyian Liu, Babak Riahi, Jiawang Zhu, Kevin Yang, Jian Chen, Rana Nomak
  • Publication number: 20050227986
    Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, d
    Type: Application
    Filed: April 5, 2005
    Publication date: October 13, 2005
    Inventors: Yunxin Bo, Partha Chakrabarti, Ning Chen, Elizabeth Doherty, Christopher Fotsch, Nianhe Han, Michael Kelly, Qingyian Liu, Mark Norman, Vassil Ognyanov, Xianghong Wang, Jiawang Zhu
  • Publication number: 20050124654
    Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Application
    Filed: April 12, 2004
    Publication date: June 9, 2005
    Inventors: Robert Groneberg, Bonny Askew, Derin D'Amico, James Zhan, Andras Toro, Youngboo Kim, David Mareska, Nianhe Han, Christopher Fotsch, Qingyian Liu, Babak Riahi, Kevin Yang, Aiwen Li, Chester Yuan, Kaustav Biswas, Scott Harried, Thomas Nguyen, Wenyuan Qian, Jian Chen, Rana Nomak
  • Publication number: 20050014749
    Abstract: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Application
    Filed: June 21, 2004
    Publication date: January 20, 2005
    Inventors: Jian Chen, Ben Askew, Kaustav Biswas, Jennifer Chau, Derin D'Amico, Scott Harried, Thomas Nguyen, Wenyuan Qian, Jiawang Zhu, Christopher Fotsch, Aiwen Li, Qingyian Liu, Nobuku Nishimura, Tanya Peterkin, Babak Riahi, Chester Yuan, Nianhe Han, Rana Nomak, Kevin Yang