Abstract: An e-mail routing system includes an e-mail program on a plurality of computers using a network for an e-mail system to minimize receipt of misaddressed e-mails. A knowledge base or database contains reference data associated with each of the recipient e-mail addresses in the e-mail system. A content analyzer program analyzes e-mail content data. A relevancy score generator program generates a relevancy score for each e-mail recipient. The relevancy score is derived from associating the reference data corresponding to each possible recipient e-mail addresses with the e-mail data. A specified minimal relevancy score is selected and low relevancy score recipient e-mails are associated by the content analyzer program with a plurality of possible recipient e-mail addresses having high relevancy scores. The relevancy score generator program selects at least one recipient from the possible recipient e-mail addresses and initiates sending the selected recipient the corresponding e-mail(s) using the e-mail program.