Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: A threat management system features a recommendation engine and an action engine. The recommendation engine is configured to (i) conduct analytics on content from the threat catalog and content from the enterprise profile to generate results that identify a plurality of threats directed to the enterprise and (ii) generate a top threat list based on the analytic results. The action engine is communicatively coupled to the recommendation engine. The action engine is configured to receive the top threat list and generate a plurality of actions corresponding to each threat of the top threat list, where each action of the plurality of actions includes information directed to operations to mitigate or neutralize a risk associated with a threat of the top threat list.

Abstract: A computerized method features operations conducted by a security analyzer device to process incoming information to ascertain a presence of cybersecurity threats based on a top threat list provided to the security analyzer device. The top threat list includes a plurality of cybersecurity threats prioritized for an enterprise that is subscribing to a threat management system and protected by the security analyzer device. The computerized method further conducts analytics of incoming information to determine a level of correlation between at least a portion of the incoming information and any of the plurality of cybersecurity threats within the top threat lists content, and upon determining the level of correlation between the portion of the incoming information and a cybersecurity threat of the plurality of cybersecurity threats exceeding a first threshold, may conduct operations to neutralize or mitigate the cybersecurity threat.

Abstract: Disclosed are synthetic nanocarrier compositions, and related methods, comprising MHC Class II-restricted epitopes and immunosuppressants that provide tolerogenic immune responses, such as a reduction in CD4+ T cell help specific to an antigen.

Abstract: Disclosed are synthetic nanocarrier compositions, and related methods, comprising therapeutic protein APC presentable antigens and immunosuppressants that provide tolerogenic immune responses specific to therapeutic proteins.

Abstract: Disclosed are synthetic nanocarrier compositions, and related methods, comprising immunosuppressants and MHC Class II-restricted epitopes of an allergen that provide tolerogenic immune responses specific to the allergen.

Abstract: Disclosed are synthetic nanocarrier compositions, and related methods, comprising immunosuppressants and MHC Class II-restricted epitopes of an allergen that provide tolerogenic immune responses specific to the allergen.

Abstract: This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects. Such compositions can further comprise antigen and provide antigen-specific tolerogenic immune responses.

Abstract: The present invention relates to non-thermal renewable energy turbines (20,24,34, 38,40), in particular to the monitoring of turbine performance to identify a loss of performance indicative of faults or component degradation. The method involves comparison of measured power from a target turbine (20) with a predicted value for same turbine. The predicted value is calculated using the output from a plurality of other turbines (24,34,38,40) from an array and a predictive model including weightings for the other turbines (24, 34,38,40) based on the strength of correlation of their historical with historical data from the target turbine (20).

Abstract: A trailer for use with a towing vehicle having a first connector. The trailer includes a connector assembly, a plurality of wheels, and a trailer assist assembly. The connector assembly includes a second connector and at least one sensor. The second connector is configured to be coupled to the first connector to thereby couple the trailer to the towing vehicle. The at least one sensor is configured to detect forces applied to at least a portion of the connector assembly. The trailer assist assembly includes a control system and at least one electric motor. The control system is configured to control operation of the at least one electric motor, receive sensor signals from the at least one sensor, and use the sensor signals to determine when to operate the at least one electric motor. The at least one electric motor is operable to drive the plurality of wheels.

Abstract: The present invention relates to methods and systems for binary scrambling, and applications for cybersecurity technology aimed at preventing cyber-attacks.

Abstract: Disclosed are synthetic nanocarrier methods, and related compositions, comprising administering immunosuppressants and MHC Class I-restricted and/or MHC Class II-restricted epitopes that can generate tolerogenic immune responses (e.g., antigen-specific T effector cell deletion).

Abstract: Disclosed are synthetic nanocarrier methods, and related compositions, comprising administering MHC Class I-restricted and/or MHC Class II-restricted epitopes of an antigen and immunosuppressants in order to generate tolerogenic immune responses against the antigen, such as the generation of antigen-specific CD8+ regulatory T cells.

Abstract: The present invention relates to methods and systems for binary scrambling, and applications for cybersecurity technology aimed at preventing cyber-attacks.

Abstract: Disclosed are synthetic nanocarrier methods, and related compositions, comprising administering MHC Class I-restricted and/or MHC Class II-restricted epitopes of an antigen and immunosuppressants in order to generate tolerogenic immune responses against the antigen, such as the generation of antigen-specific CD8+ regulatory T cells.

Abstract: Disclosed are synthetic nanocarrier methods, and related compositions, comprising administering immunosuppressants and MHC Class I-restricted and/or MHC Class II-restricted epitopes that can generate tolerogenic immune responses (e.g., antigen-specific T effector cell deletion).

Abstract: Disclosed are synthetic nanocarrier methods, and related compositions, comprising administering MHC Class I-restricted and/or MHC Class II-restricted epitopes of an antigen and immunosuppressants in order to generate tolerogenic immune responses against the antigen, such as the generation of antigen-specific CD8+ regulatory T cells.

Abstract: Disclosed are synthetic nanocarrier methods, and related compositions, comprising administering immunosuppressants and MHC Class I-restricted and/or MHC Class II-restricted epitopes that can generate tolerogenic immune responses (e.g., antigen-specific T effector cell deletion).

Abstract: Disclosed are synthetic nanocarrier compositions, and related methods, comprising immunosuppressants and MHC Class II-restricted epitopes of an allergen that provide tolerogenic immune responses specific to the allergen.

Abstract: Disclosed are synthetic nanocarrier compositions, and related methods, comprising therapeutic protein APC presentable antigens and immunosuppressants that provide tolerogenic immune responses specific to therapeutic proteins.