Abstract: A flow governor for use in a medicinal inhaler. The flow governor can include (i) a tubular element that defines at least a portion of an air flow path, the tubular element comprising at least one flexible wall configured to flex inwardly in response to an air flow in the air flow path; and (ii) an internal support structure, located within the tubular element and configured to preserve at least a predetermined cross-sectional area of the air flow path within the tubular element when the at least one flexible wall of the tubular element flexes inwardly.

Abstract: A flow governor assembly for use with a medicinal inhaler. The assembly can include a housing that defines an air flow path; a flow governor positioned in the air flow path to govern air flow in the air flow path to a target governing volumetric flow rate; and a constriction in the air flow path. The flow governor can be configured to provide a variable, or dynamic, resistance to air flow in the air flow path as a function of air pressure drop between an inlet and an outlet of the flow governor. The constriction can be configured to provide a fixed, or static, resistance to air flow in the air flow path.

Abstract: A system for use with an inhaler includes an actuator housing. The system includes a loudspeaker disposed within the actuator housing. The loudspeaker is configured to emit an acoustic pulse during use of the inhaler by a patient. The system also includes a microphone disposed within the actuator housing. The microphone is configured to receive reflected sound generated in response to the acoustic pulse. The system further includes a controller communicably coupled to the microphone. The controller is configured to determine a parameter of the oral cavity of the patient based on the reflected sound.

Abstract: A flow governor for use in a medicinal inhaler. The flow governor can include (i) a tubular element that defines at least a portion of an air flow path, the tubular element comprising at least one flexible wall configured to flex inwardly in response to an air flow in the air flow path; and (ii) an internal support structure, located within the tubular element and configured to preserve at least a predetermined cross-sectional area of the air flow path within the tubular element when the at least one flexible wall of the tubular element flexes inwardly.

Abstract: A medicinal inhaler. The inhaler can include a housing, and an air flow path defined by at least partially the housing and including an air inlet and an air outlet. The inhaler can further include a flow governor and a breath-actuated dose release firing system. The flow governor can be positioned in the air flow path between the air inlet and the air outlet to govern air flow in the air flow path to a governing volumetric flow rate. The breath-actuated dose release firing system can be located in the housing and can be configured to release a dose of medicament at a firing volumetric flow rate less than the governing volumetric flow rate.

Abstract: A flow governor assembly for use with a medicinal inhaler. The assembly can include a housing that defines an air flow path; a flow governor positioned in the air flow path to govern air flow in the air flow path to a target governing volumetric flow rate; and a constriction in the air flow path. The flow governor can be configured to provide a variable, or dynamic, resistance to air flow in the air flow path as a function of air pressure drop between an inlet and an outlet of the flow governor. The constriction can be configured to provide a fixed, or static, resistance to air flow in the air flow path.

Abstract: The present invention relates to methods of making medicinal aerosol canisters (10), in particular metered dose canisters (10), comprising aerosol formulation comprising medicament particles suspended in liquid propellant, for example for delivery by pulmonary or nasal inhalation as well as medicinal dispensers (100) including such canisters (10), such as metered dose medicinal dispenser in particular pressurized metered dose inhalers, wherein the liquid propellant in some embodiments contains HFA 134a and/or HFA 227, and the propellant component is subjected to one or more ultrasonic probes.

Abstract: The present invention relates to methods of making medicinal aerosol canisters (10), in particular metered dose canisters (10), comprising aerosol formulation comprising medicament particles suspended in liquid propellant, for example for delivery by pulmonary or nasal inhalation as well as medicinal dispensers (100) including such canisters (10), such as metered dose medicinal dispenser in particular pressurized metered dose inhalers, wherein the liquid propellant in some embodiments contains HFA 134a and/or HFA 227, and the propellant component is subjected to one or more ultrasonic probes.

Abstract: A medical inhalation device or a component thereof having a diamond-like glass coating comprising hydrogen and on a hydrogen free basis about 20 to about 40 atomic percent of silicon, greater than 39 atomic percent of carbon, and less than 33 down to and including zero atomic percent of oxygen.

Abstract: A medical inhalation device or a component thereof having a diamond-like glass coating comprising hydrogen and on a hydrogen free basis about 20 to about 40 atomic percent of silicon, greater than 39 atomic percent of carbon, and less than 33 down to and including zero atomic percent of oxygen.

Abstract: A composition for modifying a surface of a substrate, the composition comprising: (a) a first polyfluoropolyether silane of the Formula Ia: CF3CF2CF2O(CF(CF3)CF2O)pCF(CF3)—C(O)NH(CH2)3Si(Y)3 wherein each Y is independently a hydrolyzable group and wherein p is 3 to 50; and (b) a second polyfluoropolyether silane of the Formula IIa: (Y?)3Si(CH2)3NHC(O)—CF2O(CF2O)m(C2F4O)qCF2-C(O)NH(CH2)3Si(Y?)3 wherein each Y? is independently a hydrolyzable group and wherein m is 1 to 50 and q is 3 to 40. A method of making a medicinal inhalation device or a component of a medicinal inhalation device comprising a step of applying to at least a portion of a surface of the device or the component, respectively, the composition.