Patents by Inventor Christopher G. Nasveschuk

Christopher G. Nasveschuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250127903
    Abstract: This invention provides amine-linked C3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation.
    Type: Application
    Filed: July 16, 2024
    Publication date: April 24, 2025
    Applicant: C4 THERAPEUTICS, INC.
    Inventors: Andrew J. Phillips, Christopher G. Nasveschuk, James A. Henderson, Yanke Liang, Chi-Li Chen, Martin Duplessis, Minsheng He, Kiel Lazarski
  • Publication number: 20250122179
    Abstract: This invention provides Degron compounds which bind to cereblon which is a component of the E3 ubiquitin ligase. The Degrons provided herein can be used to modulate the activity of cereblon either alone or as covalently linked to a Tail. Alternatively, the Degron can be linked to a Targeting Ligand which binds to a Target Protein for protein degradation.
    Type: Application
    Filed: December 6, 2024
    Publication date: April 17, 2025
    Applicant: C4 THERAPEUTICS, INC.
    Inventors: Christopher G. Nasveschuk, Kiel Lazarski, Yanke Liang, Alexander W. Hird, Ning Yin, Andrew Charles Good, Hongwei Huang, Scott Joseph Eron, Gesine Kerstin Veits
  • Publication number: 20250121070
    Abstract: The invention provides a bifunctional compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, Cy1, Cy2, Cy3, Cy4, Z1, Z2 and the degron are as described herein.
    Type: Application
    Filed: December 12, 2024
    Publication date: April 17, 2025
    Applicant: C4 THERAPEUTICS, INC.
    Inventors: Christopher G. Nasveschuk, Kiel Lazarski, Yanke Liang, Hongwei Huang, Andrew Charles Good, Alexander W. Hird, Ning Yin, James A. Henderson, Eunice Sun Park, Scott Joseph Eron, Richard Wendel Deibler, Katrina L. Jackson
  • Publication number: 20250121069
    Abstract: This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.
    Type: Application
    Filed: July 17, 2024
    Publication date: April 17, 2025
    Applicant: C4 THERAPEUTICS, INC.
    Inventors: Andrew J. Phillips, Christopher G. Nasveschuk, James A. Henderson, Yanke Liang, Mark E. Fitzgerald, Minsheng He, Ryan E. Michael
  • Publication number: 20250115580
    Abstract: The present invention provides compounds or their pharmaceutically acceptable salts and their pharmaceutical compositions that can be administered to a host such as a human in need thereof for the treatment of a disorder, such as cancer, mediated by mutant BRAF. The compounds efficiently degrade Class I, II and III mutant BRAF proteins.
    Type: Application
    Filed: December 13, 2024
    Publication date: April 10, 2025
    Applicant: C4 THERAPEUTICS, INC.
    Inventors: Christopher G. Nasveschuk, Katrina L. Jackson, Yanke Liang, Martin Duplessis, Mark E. Fitzgerald, Cosimo Dolente, David Stephen Hewings, Daniel Hunziker, Daniela Krummenacher, Piergiorgio Francesco Tommaso Pettazzoni, Juergen Wichmann
  • Publication number: 20250101037
    Abstract: This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.
    Type: Application
    Filed: December 9, 2024
    Publication date: March 27, 2025
    Applicant: C4 THERAPEUTICS, INC.
    Inventors: Andrew J. Phillips, Christopher G. Nasveschuk, James A. Henderson, Yanke Liang, Minsheng He, Martin Duplessis, Chi-Li Chen
  • Publication number: 20250084081
    Abstract: BRD9 protein degradation compounds or pharmaceutically acceptable salts thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.
    Type: Application
    Filed: November 12, 2024
    Publication date: March 13, 2025
    Applicant: C4 THERAPEUTICS, INC.
    Inventors: Christopher G. Nasveschuk, Rhamy Zeid, Ning Yin, Katrina L. Jackson, Gesine Kerstin Veits, Moses Moustakim, Jeremy L. Yap
  • Publication number: 20250057957
    Abstract: This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.
    Type: Application
    Filed: July 16, 2024
    Publication date: February 20, 2025
    Applicant: C4 THERAPEUTICS, INC.
    Inventors: Andrew J. Phillips, Christopher G. Nasveschuk, James A. Henderson, Yanke Liang, Kiel Lazarski, Ryan E. Michael
  • Patent number: 12227504
    Abstract: The present invention provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.
    Type: Grant
    Filed: January 24, 2023
    Date of Patent: February 18, 2025
    Assignee: C4 Therepeutics, Inc.
    Inventors: Christopher G. Nasveschuk, Fabian Dey, Annick Goergler, Bernd Kuhn, Roger Norcross, Stephan Roever, Philipp Schmid
  • Publication number: 20250018046
    Abstract: This disclosure relates to compounds of Formula (A): Formula (A), or a pharmaceutically acceptable salt thereof, wherein DSM is a degradation signaling moiety that is covalently attached to the linker L, L is a linker that covalently attaches IRAK to DSM; and IRAK is an IRAK4 binding moiety represented by Formula (I) that is covalently attached to linker L; Formula (I) in which all of the variables are as defined in the application. Compounds or pharmaceutically acceptable salts thereof as described herein are capable of activating the selective ubiqitination of IRAK4 proteins via the ubiquitin-proteasome pathways (UPP) and cause degradation of IRAK4 proteins. The present disclosure also provides methods of treating disorders responsive to modulation of IRAK4 activity and/or degradation of IRAK4 with at least one compound described herein.
    Type: Application
    Filed: July 7, 2022
    Publication date: January 16, 2025
    Inventors: Kevin M. Guckian, Emily Anne Peterson, Fang Gao, Ryan Evans, Eric Stefan, Jeremy L. Yap, Corey Don Anderson, Morgan Weizel O'Shea, Jae Young M. Ahn, Christopher G. Nasveschuk, James A. Henderson
  • Patent number: 12180225
    Abstract: This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.
    Type: Grant
    Filed: October 3, 2022
    Date of Patent: December 31, 2024
    Assignee: C4 Therapeutics, Inc.
    Inventors: Andrew J. Phillips, Christopher G. Nasveschuk, James A. Henderson, Yanke Liang, Minsheng He, Martin Duplessis, Chi-Li Chen
  • Publication number: 20240398959
    Abstract: This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.
    Type: Application
    Filed: April 22, 2024
    Publication date: December 5, 2024
    Applicant: C4 THERAPEUTICS, INC.
    Inventors: Andrew J. Phillips, Christopher G. Nasveschuk, James A. Henderson, Yanke Liang, Minsheng He, Kiel Lazarski, Gesine Kerstin Veits, Harit U. Vora
  • Patent number: 12157735
    Abstract: BRD9 protein degradation compounds or pharmaceutically acceptable salts thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.
    Type: Grant
    Filed: October 13, 2022
    Date of Patent: December 3, 2024
    Assignee: C4 Therapeutics, Inc.
    Inventors: Christopher G. Nasveschuk, Rhamy Zeid, Ning Yin, Katrina L. Jackson, Gesine Kerstin Veits, Moses Moustakim, Jeremy L. Yap
  • Publication number: 20240383886
    Abstract: Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer 5 or a metabolic disease.
    Type: Application
    Filed: December 18, 2020
    Publication date: November 21, 2024
    Inventors: Gesine Kerstin Veits, Mark E. Fitzgerald, Alexander W. Hird, James A. Henderson, Harit U. Vora, Ramzi F. Sweis, Michael E. Kort, Christopher G. Nasveschuk, Martin Duplessis
  • Publication number: 20240343733
    Abstract: This disclosure relates to compounds of Formula (A): IRAK-L-DSM (A), or a pharmaceutically acceptable salt thereof, wherein DSM is a degradation signaling moiety that is covalently attached to the linker L, L is a linker that covalently attaches IRAK to DSM; and IRAK is an IRAK4 binding moiety represented by Formula (I) that is covalently attached to linker L; in which all of the variables are as defined in the application. Compounds or pharmaceutically acceptable salts thereof as described herein are capable of activating the selective ubiqitination of IRAK4 proteins via the ubiquitin-proteasome pathways (UPP) and cause degradation of IRAK4 proteins. The present disclosure also provides methods of treating disorders responsive to modulation of IRAK4 activity and/or degradation of IRAK4 with at least one compound described herein.
    Type: Application
    Filed: July 7, 2022
    Publication date: October 17, 2024
    Inventors: Kevin M. Guckian, Emily Anne Peterson, Fang Gao, Ryan Evans, Eric Stefan, Jeremy L. Yap, Corey Don Anderson, Morgan Welzel O'Shea, Jae Young M. Ahn, Christopher G. Nasveschuk, James A. Henderson
  • Patent number: 12076405
    Abstract: This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: September 3, 2024
    Inventors: Andrew J. Phillips, Christopher G. Nasveschuk, James A. Henderson, Yanke Liang, Mark E. Fitzgerald, Minsheng He, Ryan E. Michael
  • Patent number: 12048747
    Abstract: This invention provides amine-linked C3-glutarimide Degronimers for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation, wherein the C3-glutarimide Degronimers have the formula:
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: July 30, 2024
    Assignee: C4 Therapeutics, Inc.
    Inventors: Andrew J. Phillips, Christopher G. Nasveschuk, James A. Henderson, Yanke Liang, Chi-Li Chen, Martin Duplessis, Minsheng He, Kiel Lazarski
  • Patent number: 12048748
    Abstract: This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.
    Type: Grant
    Filed: November 11, 2021
    Date of Patent: July 30, 2024
    Assignee: C4 Therapeutics, Inc.
    Inventors: Andrew J. Phillips, Christopher G. Nasveschuk, James A. Henderson, Yanke Liang, Kiel Lazarski, Ryan E. Michael
  • Patent number: 12049464
    Abstract: BRD9 protein degradation compounds or pharmaceutically acceptable salts thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.
    Type: Grant
    Filed: September 1, 2022
    Date of Patent: July 30, 2024
    Assignee: C4 Therapeutics, Inc.
    Inventors: Christopher G. Nasveschuk, Rhamy Zeid, Ning Yin, Katrina L. Jackson, Gesine Kerstin Veits, Moses Moustakim, Jeremy L. Yap
  • Publication number: 20240245677
    Abstract: Selected BRD9 protein degradation compounds and morphic forms thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.
    Type: Application
    Filed: March 8, 2024
    Publication date: July 25, 2024
    Applicant: C4 THERAPEUTICS, INC.
    Inventors: Katrina L. Jackson, Christopher G. Nasveschuk, Rhamy Zeid, Ning Yin, Gesine Kerstin Veits, Moses Moustakim, Jeremy L. Yap, Minsheng He, Robert T. Yu, Matthew J. Schnaderbeck, Kathleen Neville, Siyi Jiang, Meiqi Li, Qianwei Liu, Manjie Zheng, Jia Li, Liwei Zhang