Abstract: A mechanical swing brake variable control system for an earth-moving machine including an upper revolving car body with swing components mounted on the upper revolving car body, a lower traveling car body with traction components mounted on the lower traveling car body, and a mechanical service brake interconnected with the upper and lower car bodies, controls relative rotation between the upper and lower car bodies. A pressure control device controls a variable pressure applied to the mechanical service brake to vary an amount of swing drive holding torque. An electronic controller monitors and processes signals received from sensors associated with the swing components and machine operator commands, and variably controls the amount of holding torque exerted on the upper revolving car body using the mechanical service brake as a function of one or more of machine roll angle, operational configuration of the swing components, inertial mass of the swing components, and machine operator commands.

Abstract: Techniques are disclosed for usage-tracking of various information security (InfoSec) entities for tenants/organization onboarded on an instant multi-tenant security assurance platform. The InfoSec entities include policies, procedures, controls and evidence tasks. A policy or procedure is enforced by implementing one or more controls, and the collection of one or more evidence tasks proves/verifies the implementation of a control. The InfoSec entities are linked to each other across the platform and accrue a number of benefits for the tenants. These include generating a security questionnaire response (SQR), defining a readiness project and an audit project, sharing InfoSec entities encompassing the various products of a tenant, automating risk assessment, automatic collection of evidence tasks for verifying the implementation and/or operational state/status of various mitigating controls, etc.

Abstract: Disclosed herein are novel gene editing systems capable of being delivered to a subject intravenously through a lipid nano particle pharmaceutical formulation and producing durable in vivo editing of a target gene, such as ANGPTL3, with high on-target gene editing efficiency, reduced or low off-target effect, and no germline editing. The gene editing systems comprise a chemically modified guide nucleic acid sequence with a spacer having a specified arrangement of deoxyribonucleotides and ribonucleotides. The novel gene editing systems comprise mRNA that encodes the gene editor proteins, which may include a modified nickase component. Methods of disease treatments using the gene editing systems are also disclosed.

Abstract: Methods, systems, and non-transitory computer readable storage media are disclosed for managing computing systems according to detect and correct configuration gaps with specific system requirements frameworks. Specifically, the disclosed system accesses a digital data repository to determine attribute values of data objects representing functions or infrastructure associated with handling target data for an entity. The disclosed system determines a digital representation of a system requirements framework that indicates controls associated with handling specific data types. Based on the attribute values and a gap rules set associated with the system requirements framework, the disclosed system determines configuration gaps to be addressed via control actions for installing controls in connection with various data assets or data processes.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: A computer system that includes one or more processors configured to execute a secure sovereign manager that controls remote execution of commands on a sovereign cloud computing platform. The secure sovereign manager is configured to create an escorted session for an unqualified user for invoking commands on the sovereign cloud computing platform. The unqualified user does not have sovereign-trusted credentials that define qualifications required for accessing the sovereign cloud computing platform. The escorted session is asynchronously supervised by a qualified user that has sovereign-trusted credentials. The secure sovereign manager is configured to receive an indication of approval or denial of invocation of a received command. Based on at least receiving an indication of approval, the secure sovereign manager invokes the received command on the sovereign cloud computing platform.

Abstract: In response to receiving user input command for sending a contextually aware communication, a computer system is configured to use game state data to determine a target location that a player is focusing on in a virtual environment in a video game, identify a unit that the player likely wants to communicate about based on at least priorities of unit types and proximities of units to the target location, and select a communication action for performance. Different communication actions can be performed in response to the same user input command when the game state data indicates different game states.

Abstract: Secondary batteries and methods of manufacture thereof are provided. A secondary battery can comprise an offset between electrode and counter-electrode layers in a unit cell. Secondary batteries can be prepared by removing a population of negative electrode subunits from a negative electrode sheet, the negative electrode sheet comprising a negative electrode sheet edge margin and at least one negative electrode sheet weakened region that is internal to the negative electrode sheet edge margin, removing a population of separator layer subunits from a separator sheet, and removing a population of positive electrode subunits from a positive electrode sheet, the positive electrode sheet comprising a positive electrode edge margin and at least one positive electrode sheet weakened region that is internal to the positive electrode sheet edge margin, and stacking members of the negative electrode subunit population, the separator layer subunit population and the positive electrode subunit population.

Abstract: Methods, systems, and non-transitory computer readable storage media are disclosed for managing user access levels to computing software applications based on user state changes detected via integration with a third-party system. Specifically, the disclosed system determines a user data object representing a user state associated with a user account in connection with a group of users of an entity by integrating with a third-party user management system. The disclosed system determines application data objects representing computing software applications that correspond to the group of users. Based on the user state, the disclosed system modifies a user access level of the user data object for a computing software application corresponding to the group of users. The disclosed system can generate a request to modify the user access level for providing to an administrator client device or automatically modify the user access level via integration with the third-party user management system.

Abstract: A sensor pod system includes one or more sensor pods with a plurality of sensors configured to collect data from an environment. A sensor pod may have an effective field of view created by individual sensors with overlapping fields of view. The sensor pod system may include sensors of different types and modalities. Sensor pods of the sensor pod system may be modularly installed on a vehicle, for example, an autonomous vehicle and collect and provide data of the environment during operation of the vehicle.

Abstract: A computer system that includes one or more processors configured to execute a secure sovereign manager that controls remote execution of commands on a sovereign cloud computing platform. The secure sovereign manager is configured to create an escorted session for an unqualified user for invoking commands on the sovereign cloud computing platform. The unqualified user does not have sovereign-trusted credentials that define qualifications required for accessing the sovereign cloud computing platform. The escorted session is asynchronously supervised by a qualified user that has sovereign-trusted credentials. The secure sovereign manager is configured to receive an indication of approval or denial of invocation of a received command. Based on at least receiving an indication of approval, the secure sovereign manager invokes the received command on the sovereign cloud computing platform.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: An embodiment firearm accessory mount includes: a main base including: a firearm groove at a bottom of the main base; and a mating groove at a top of the main base, the mating groove extending from a front of the main base to a rear of the main base, a first width of the mating groove decreasing continually in a first direction extending from the front of the main base to the rear of the main base; and an accessory mount including: an accessory groove at a top of the accessory mount; and a mating slide at a bottom of the accessory mount, the mating slide extending from a front of the accessory mount to a rear of the accessory mount, a second width of the mating slide decreasing continually in a second direction extending from the front of the accessory mount to the rear of the accessory mount.

Abstract: An example method includes receiving, at a CPU, a data request from a data requester to search or filter data in a repository. At least a first portion of the data is homomorphically encrypted. The method includes analyzing the stored data without decrypting the homomorphically encrypted data to determine an aggregated subset of data relevant to the data request. The analyzing includes: dispatching, from the CPU, a command to a hardware accelerator to execute an operation on the homomorphically encrypted data; executing, at the hardware accelerator, the operation on the homomorphically encrypted data; and receiving, at the CPU, an output of the execution of the operation by the hardware accelerator, where the aggregated subset of data is based on the output. The method includes providing data request results that include or are derived from the aggregated subset of data to the data requester.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The present disclosure generally relates to the secure exchange of data. In some implementations, an example method involves receiving data from a number of independent data sources. The method also includes storing the data in a central repository where at least a first portion of the data is homomorphically encrypted, receiving a data request from a data requester, and analyzing the stored data without decrypting the homomorphically encrypted data to determine an aggregated subset of data relevant to the data request. The aggregated subset of data may include at least some of the homomorphically encrypted data. The method also includes providing data request results that include or are derived from the aggregated subset of data to the data requester.

Abstract: A method and apparatus of re-railing a rail car involving the use of one or more extendable arms carried by each individual rail car is provided. The extendable arms may be operable to extend outward from the rail car and then lower an extendable foot to contact the ground, thus allowing the car to be raised into position back over the rails of the associated train tracks utilizing these extendable arms. Since the arms are compact and carried by the rail car themselves, there is no time lost while lifting equipment is brought in and cars may be quickly and efficiently re-railed to minimize the overall time loss of the associated train tracks.