Abstract: The present disclosure relates to predicting a patient's response to cancer therapy based on the presence or absence of loss of function NOD-2 variants, as well as methods of treating cancer comprising inhibiting NOD-2 function.

Abstract: The present disclosure relates to an improved methodology for phenotyping and molecular characterisation of single cells using high-throughput and multiplexed targeted long-read single cell sequencing. In one particular example, the present disclosure relates to a methodology which combines targeted long-read sequencing with short-read based transcriptome profiling of barcoded single cell libraries generated by droplet-based partitioning for high throughput deep single cell profiling.

Abstract: The present disclosure relates to methods of generating antibodies with improved specificity and/or affinity for a target antigen, as well as B-cells and hybridomas expressing the antibodies and compositions comprising antibodies with improved specificity and/or affinity for the target antigen.

Abstract: A computer-implemented method generates a set-point temperature for an evaporative cooler supplying cooled water to a chiller. Under the control of one or more computer systems configured with executable instructions, an achievable temperature for water supplied to the chiller by the evaporative cooler is generated based at least in part on an outside wet bulb temperature. A set-point temperature for the water supplied to the chiller by the evaporative cooler is then generated. The set-point temperature is the greater of the achievable temperature and a minimum temperature for water that can be used by the chiller without causing damage to the chiller.

Abstract: The present invention relates to the discovery, identification, and characterization of novel genes encoding proteins that play a role in immune system development and function, collectively termed Nessie. The invention encompasses the described polynucleotides, the encoded proteins, fusion proteins, polypeptides and peptides, genetically engineered animals that either under- or over-express the disclosed sequences, antibodies to the encoded proteins and peptides, host cell expression systems, antagonists and agonists of the proteins, and other compounds that modulate the expression or activity of the proteins encoded by the disclosed sequences that can be used for diagnosis, drug screening, clinical trial monitoring and the treatment of diseases and disorders.