Abstract: A method is proposed for detecting at least one fluorescence pattern on an immunofluorescence image of a biological cell substrate, comprising the following steps: incubating the cell substrate with a liquid patient sample, which potentially includes primary antibodies, and furthermore with secondary antibodies, which are marked using a fluorescence stain, irradiating the cell substrate using excitation radiation and capturing the immunofluorescence image, determining segmentation information comprising at least one first and one second segmentation area, wherein the segmentation areas each represent a respective cell substrate area, via segmentation of the immunofluorescence image using a first neural network, determining a boundary area, which represents a transition from the first cell substrate area towards the second cell substrate area in the fluorescence image, on the basis of the segmentation information, selecting multiple partial images from the immunofluorescence image along the boundary area, dete

Abstract: A method is proposed for detecting a presence of a fluorescence pattern on an immunofluorescence image of a biological cell substrate, comprising the following steps: incubating the cell substrate with a liquid patient sample, which potentially comprises primary antibodies, and furthermore with secondary antibodies, which are marked using a fluorescence stain, irradiating the cell substrate using excitation radiation and capturing the immunofluorescence image, determining respective items of location information, which indicate respective locations of respective relevant subsections of the cell substrate in the fluorescence image, and determining respective first partial confidence measures of respective presences of the fluorescence pattern on the respective subsections by means of a first neural network on the basis of the overall fluorescence image, extracting respective image subsections, which correspond to the respective subsections of the cell substrate, from the fluorescence image on the basis of the

Abstract: Early detection of lysosomal storage diseases (LSDs) including Mucopolysaccharidosis Type I (MPS I) and Pompe Disease can greatly improve patient outcome as each disease can be fatal once symptoms emerge. Screening for MPS I and Pompe Disease using biological samples including dried blood spots (DBS), buccal swab, peripheral blood mononuclear cells (PBMCs), or white blood cells (WBCs) is described. The disclosed methods and assays provide a robust way to screen newborns for LSDs. The disclosed methods and assays can also allow rapid prediction of whether a patient with LSD will develop an immune response to enzyme replacement therapy (ERT), thus improving treatment for patients with LSDs. The disclosed methods and assays can also further reduce the number of false positives caused by pseudo deficiency cases of LSD, such as MPS I and Pompe Disease.

Abstract: An integrated fuel management system can include a switching unit coupled to an electric vehicle (EV) charging station, a computer system, a first electronic unit, and a second electronic unit. The first electronic unit can be coupled to the switching unit and operable for providing state information for the EV charging station to the computer system. The second electronic unit can be coupled to a fueling station for types of vehicles that use fuel and operable for providing state information for the fueling station to the computer system. Further, the computer system can be operable for displaying the state information for the EV charging station and for displaying the state information for the fueling station.

Abstract: A method for recovering a composition enriched in 3-hydroxypropionic acid from a fermentation broth comprising 3-hydroxypropionic acid and/or salts thereof comprises the steps of: (a) providing the fermentation broth having a pH of from about 2 to about 8 comprising: 3-hydroxypropionic acid and/or salts thereof, (b) acidifying the fermentation broth; (c) reducing the total sulfate ion and phosphate ion (d) distilling the resulting reduced ion aqueous solution and (e) recovering the product.

Abstract: A bicycle front shifting system includes operable to transmit a wireless signal, a crank assembly with two crank arms and a pedal on each of the two crank arms. The crank assembly is rotatable about a rotation axis. A front shift unit is coupled to the crank assembly and is rotatable about the rotation axis. The front shift unit includes a chain ring component with a big chain ring and a small chain ring. The small chain ring has a small diameter and the big chain ring has a big diameter that is larger than the small diameter. A shift mechanism is coupled to and rotatable with the chain ring component about the rotation axis. The shift mechanism is configured to receive the wireless signal from the shifter and to shift a chain between the big chain ring and the small chain ring according to the wireless signal.

Abstract: The invention relates to a method for applying titanium dioxide-based photocatalytic coatings to a carrier material without using binders. The invention also relates to the use of a coating. According to the invention, a titanium dioxide suspension together with a carrier liquid is sprayed onto a hot carrier in the form of a fine aerosol so that the carrier liquid flash evaporates and titanium dioxide particles of the titanium dioxide suspension are flash sintered onto the carrier material, water being used as the carrier liquid and the carrier material having a temperature of 150 to 250° C. during spraying. According to the invention, a porous and yet stable layer for a catalyst for an efficient and rapid degradation of pollutants is produced.

Abstract: Some implementations may provide a method for conducting a marketing campaign, including: providing a user interface to a marketing professional; receiving, via the interface, input from the marketing professional prescribing a sequence of at least three steps for engaging at least one target customer, the sequence comprising: a start step corresponding to a beginning point for the at least one target customer to enter into the sequence, at least one end step corresponding to a finishing line for the at least one target customer to complete the sequence, at least one step for communicating information to the at least one target customer for the at least one target customer to progress through the sequence; subsequent to determining that the sequence of steps is valid, receiving an instruction from the marketing professional to launch the sequence; and in response to the received instruction, launching the sequence to conduct the marketing campaign.

Abstract: The invention relates to a method for applying titanium dioxide-based photocatalytic coatings to a carrier material without using binders. The invention also relates to the use of a coating. According to the invention, a titanium dioxide suspension together with a carrier liquid is sprayed onto a hot carrier in the form of a fine aerosol so that the carrier liquid flash evaporates and titanium dioxide particles of the titanium dioxide suspension are flash sintered onto the carrier material, water being used as the carrier liquid and the carrier material having a temperature of 150 to 250° C. during spraying. According to the invention, a porous and yet stable layer for a catalyst for an efficient and rapid degradation of pollutants is produced.

Abstract: A method and system to retrieve data dynamically from one or more datasets are disclosed. The method comprises receiving at least one query in a first query language. Thereafter, splitting the at least one query in the first query language into a plurality of sub-queries and transforming the plurality of sub-queries into one or more second query languages, wherein the one or more second query languages correspond to the one or more datasets. Other embodiments include a method that comprises processing the one or more transformed queries to retrieve one or more query results from the one or more datasets, and processing the one or more query results to generate a data presentation.

Abstract: The disclosure generally describes computer-implemented methods, software, and systems for receiving and aggregating anonymized data reports about when prescribers provide wireless device applications to patients. The disclosure discusses ways of analyzing the data reports in combination with other electronic medical information to generate useful conclusions about scenarios in the health care process.

Abstract: The disclosure generally describes computer-implemented methods, software, and systems for receiving and aggregating anonymized data reports about when prescribers provide wireless device applications to patients. The disclosure discusses ways of analyzing the data reports in combination with other electronic medical information to generate useful conclusions about scenarios in the health care process.

Abstract: Apparatus and method to serialize electronic localized data, or to produce electronic localized data from serialized data. The apparatus to serialize includes: a receiver to collect electronic localized data; a processor coupled to the receiver, the processor configured to receive the electronic localized data collected by the receiver; a memory coupled to the processor, the memory configured to store an application program; an interface to a serialization module, to serialize electronic localized data collected by the receiver, wherein the interface is callable from the application program; and a storage module configured to store the serialized data from the serialization module.

Abstract: The disclosure generally describes computer-implemented methods, software, and systems for receiving and aggregating anonymized data reports about when prescribers provide wireless device applications to patients. The disclosure discusses ways of analyzing the data reports in combination with other electronic medical information to generate useful conclusions about scenarios in the health care process.

Abstract: Healthcare marketing data may be cleaned and normalized according to data validity and/or data canonicity rules prior to being merged into a healthcare marketing database. The merging process may include a fuzzy de-duplication operation utilizing a configurable field scoring table for automatically identifying matching and non-matching records. Potential duplicates that cannot be automatically resolved may be provided to an operator to provide merge or no-merge instructions.

Abstract: Provided herein are systems and methods for providing access to marketing data via a reduced-complexity marketer GUI for dynamically defining market segments for use in marketing campaigns.

Abstract: Personally-identifying, protected health information (“PHI”) is stored in encrypted form in protected data records, and hash values derived from the PHI are stored in associated search records. A healthcare marketer may identify market segments of individuals by querying the search records using hashed query predicates, identifying protected data records based on the search record results, and providing anonymized data-record results to the healthcare marketer. Once a market segment has been anonymously identified, the marketer may cause personalized marketing messages to be generated for individuals in the market-segment without the marketer having been exposed to PHI associated with those individuals.

Abstract: A camera includes memory for storing one or more stored images each with at least a day and month of capture; a processor which, based on the stored images, determines which day and month at least an image was captured; and a display that displays only the day and month on which at least an image was captured along with a visual indicator of whether a plurality of images was captured on the displayed day and month.

Abstract: A method of processing a substrate. In one embodiment, the invention can be a method of processing a substrate comprising: supporting the substrate in a horizontal orientation; rotating the substrate; providing a fluid dispensing apparatus adjacent a surface of the substrate, the fluid dispensing apparatus comprising a body having an outer surface and a first conduit terminating as a first hole in the outer surface of the body and a second conduit terminating as a second hole in the outer surface of the body, the first hole oriented at a non-normal angle relative to the substrate and offset a first radial distance from a rotational center-point of the substrate; and ejecting liquid out of the first hole into contact with the substrate at the rotational center-point and ejecting liquid out of the second hole into contact with the substrate at a second radial distance from the rotational center-point.

Abstract: Provided herein are systems and methods for providing access to marketing data via a reduced-complexity marketer GUI for dynamically defining market segments for use in marketing campaigns.